transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

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Synonym

HAM2, Ham-2, ATP-binding cassette sub-family B member 3, AI462429, Abcb3, Antigen peptide transporter 2, APT2, Tap-2, Histocompatibility antigen modifier 2, Y1, MTP2, RING11, PSF-2, Tap2, ABC18, PSF2, jas, Ham2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.55 cerebellum:5.71 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.60 spine:6.04 retina:5.34 eye:6 artery/aorta:- vein:5.37 lymphnode:9.34 peripheral blood:- spleen:9.22 thymus:- bone marrow:7.88 adipose:7.50 bone:7.44 skin:7.55
CAGE cerebrum:2.01 cerebellum:- brain stem:2.06 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.21 retina:- eye:- artery/aorta:3.32 vein:- lymphnode:3.80 peripheral blood:- spleen:3.57 thymus:4.01 bone marrow:- adipose:- bone:3.14 skin:2.99
RNA-seq cerebrum:3.82 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.78 placenta:6.79 prostate:7.33 ovary:7.34 testis:5.67 heart:6.99 muscle:6.56 esophagus:- stomach:6.82 intestine:7.69 colon:- liver/hepato:7.07 lung:8.07 bladder:6.81 kidney:6.59 pituitary:7.33 thyroid/parathyroid:- adrenal gland:7.83 pancreas:6.32 breast:8.35 salivary:7.27
CAGE uterus:2.97 placenta:2.42 prostate:2.73 ovary:2.86 testis:0.75 heart:- muscle:- esophagus:- stomach:2.60 intestine:3.22 colon:3.83     liver/hepato:2.87    lung:3.59 bladder:2.69 kidney:- pituitary:3.44 thyroid/parathyroid:- adrenal gland:3.14 pancreas:2.33 breast:3.48 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.29 esophagus:- stomach:- intestine:- colon:-     liver/hepato:4.57        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_011530
Gene ID 21355
Unigene ID -
Probe set ID 1453913_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024339

Orthologous Gene

Human[4]  NM_000544, NM_018833
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR017940  ABC transporter integral membrane type 1
IPR013305  ABC transporter, ABCB2
IPR013306  ABC transporter, B3
IPR011527  ABC transporter, transmembrane domain, type 1
IPR003439  ABC transporter-like
IPR005293  Antigen peptide transporter 2
IPR003593  ATPase, AAA+ type, core

Link to Pubmed  (Pubmed ID)

1339432
1380797
1473153
1538753
1711220
1979660
2270487
7737270
8022815
8107849
8294864
8325639
8662084
8799160
9164943
9250665
9260681
9764360
9845074
10349636
10922068
11011155
11042159
11076861
11133832
11217851
11238639
11976789
12466851
12477932
12594855
12679854
14681479
14735325
16141072
16141073
16299293
16602821
17202325
18061684
19721454
21267068
21378750

Gene Ontology  (GO ID)

Biological Process

GO:0019885  antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0002485  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002489  antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
GO:0002481  antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0046967  cytosol to ER transport
GO:0019060  intracellular transport of viral proteins in host cell
GO:0046968  peptide antigen transport
GO:0015833  peptide transport
GO:0002591  positive regulation of antigen processing and presentation of peptide antigen via MHC class I
GO:0001916  positive regulation of T cell mediated cytotoxicity
GO:0042270  protection from natural killer cell mediated cytotoxicity
GO:0006461  protein complex assembly
GO:0015031  protein transport
GO:0002237  response to molecule of bacterial origin
GO:0055085  transmembrane transport
GO:0006810  transport

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0030176  integral to endoplasmic reticulum membrane
GO:0016021  integral to membrane
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0042824  MHC class I peptide loading complex
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0042825  TAP complex

Molecular Function

GO:0043531  ADP binding
GO:0005524  ATP binding
GO:0016887  ATPase activity
GO:0042626  ATPase activity, coupled to transmembrane movement of substances
GO:0042288  MHC class I protein binding
GO:0017111  nucleoside-triphosphatase activity
GO:0000166  nucleotide binding
GO:0015421  oligopeptide-transporting ATPase activity
GO:0042605  peptide antigen binding
GO:0015433  peptide antigen-transporting ATPase activity
GO:0015197  peptide transporter activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0046978  TAP1 binding
GO:0046979  TAP2 binding
GO:0046980  tapasin binding
GO:0005215  transporter activity