cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

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Synonym

Cdc73, Hrpt2, C81219, MGC36559, Cell division cycle protein 73 homolog, MGC29274, 8430414L16Rik, BC027756, Hyperparathyroidism 2 protein homolog, C130030P16Rik, Parafibromin

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.16 cerebellum:3.91 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4 spine:4.09 retina:5.35 eye:4.55 artery/aorta:- vein:4.34 lymphnode:4.11 peripheral blood:- spleen:4 thymus:- bone marrow:4.16 adipose:4.22 bone:4.32 skin:4.54
CAGE cerebrum:3.62 cerebellum:- brain stem:3.43 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.45 retina:- eye:- artery/aorta:3.74 vein:- lymphnode:4.25 peripheral blood:- spleen:3.73 thymus:3.81 bone marrow:- adipose:- bone:3.38 skin:4.01
RNA-seq cerebrum:2.59 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:27.60 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:6.50 salivary:-
GeneChip uterus:4.08 placenta:5.76 prostate:4.72 ovary:4.64 testis:4.39 heart:4.15 muscle:4.71 esophagus:- stomach:3.95 intestine:4.01 colon:- liver/hepato:4.04 lung:4.21 bladder:4.39 kidney:3.95 pituitary:4.47 thyroid/parathyroid:- adrenal gland:5.14 pancreas:3.88 breast:4.23 salivary:4.23
CAGE uterus:3.72 placenta:4.54 prostate:4.02 ovary:3.97 testis:4.04 heart:- muscle:- esophagus:- stomach:3.09 intestine:3.86 colon:3.51     liver/hepato:3.42    lung:3.61 bladder:3.74 kidney:- pituitary:4.05 thyroid/parathyroid:- adrenal gland:4.15 pancreas:4.29 breast:3.76 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.87 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.49        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_145991
Gene ID 214498
Unigene ID Mm.398849
Probe set ID 1439103_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026361

Orthologous Gene

Human[1]  NM_024529
Rat[1]  NM_001024769

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8889548
10349636
10725249
10922068
11042159
11076861
11217851
12466851
12477932
12520002
12904583
14610273
15489334
15489855
15580289
15741177
16141072
16141073
16602821
17296600
17911113
18212049
18799693
19345177
21589869
21677750
22083510
22252316
23166327
23791194
23900238

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0071222  cellular response to lipopolysaccharide
GO:0001711  endodermal cell fate commitment
GO:0033523  histone H2B ubiquitination
GO:0010390  histone monoubiquitination
GO:0006378  mRNA polyadenylation
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0048147  negative regulation of fibroblast proliferation
GO:0045638  negative regulation of myeloid cell differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0031442  positive regulation of mRNA 3'-end processing
GO:0032968  positive regulation of RNA elongation from RNA polymerase II promoter
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0031648  protein destabilization
GO:0019827  stem cell maintenance
GO:0006351  transcription, DNA-dependent
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0016593  Cdc73/Paf1 complex
GO:0005634  nucleus

Molecular Function

GO:0005515  protein binding