tuberous sclerosis 2

jump to detail

Synonym

Tuberin, Tcs2, tuberous sclerosis 2, tuberin, Tuberous sclerosis 2 homolog protein, Tsc2

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:8.76 cerebellum:8.71 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.60 spine:8.87 retina:6.55 eye:6.71 artery/aorta:- vein:8.46 lymphnode:8.19 peripheral blood:- spleen:8.10 thymus:- bone marrow:8.13 adipose:8.69 bone:7.73 skin:7.87
CAGE cerebrum:3.90 cerebellum:- brain stem:3.67 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.63 retina:- eye:- artery/aorta:3.94 vein:- lymphnode:3.25 peripheral blood:- spleen:2.92 thymus:3.01 bone marrow:- adipose:- bone:3.18 skin:3.23
RNA-seq cerebrum:10.49 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:8.80 placenta:7.52 prostate:9.19 ovary:8.70 testis:7.84 heart:9.42 muscle:9.48 esophagus:- stomach:8.57 intestine:8.19 colon:- liver/hepato:8.44 lung:9.13 bladder:8.60 kidney:8.80 pituitary:8.98 thyroid/parathyroid:- adrenal gland:8.08 pancreas:8.04 breast:8.50 salivary:7.68
CAGE uterus:3.35 placenta:3.00 prostate:3.84 ovary:3.38 testis:3.39 heart:- muscle:- esophagus:- stomach:3.05 intestine:2.56 colon:3.23     liver/hepato:3.28    lung:3.54 bladder:3.43 kidney:- pituitary:3.61 thyroid/parathyroid:- adrenal gland:3.52 pancreas:3.57 breast:3.22 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:7.12 esophagus:- stomach:- intestine:- colon:-     liver/hepato:7.20        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

IDs

Refseq ID NM_011647
Gene ID 22084
Unigene ID -
Probe set ID 1452105_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000002496

Orthologous Gene

Human[3]  NM_000548, NM_001077183, NM_001114382
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0006953  acute-phase response
GO:0030030  cell projection organization
GO:0045184  establishment of protein localization
GO:0007507  heart development
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0045792  negative regulation of cell size
GO:0050680  negative regulation of epithelial cell proliferation
GO:0043407  negative regulation of MAP kinase activity
GO:0014067  negative regulation of phosphoinositide 3-kinase cascade
GO:0006469  negative regulation of protein kinase activity
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0032007  negative regulation of TOR signaling pathway
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0001843  neural tube closure
GO:0014065  phosphoinositide 3-kinase cascade
GO:0050918  positive chemotaxis
GO:0043547  positive regulation of GTPase activity
GO:0051291  protein heterooligomerization
GO:0051260  protein homooligomerization
GO:0006606  protein import into nucleus
GO:0043491  protein kinase B signaling cascade
GO:0008104  protein localization
GO:0051726  regulation of cell cycle
GO:0030100  regulation of endocytosis
GO:0046626  regulation of insulin receptor signaling pathway
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0001666  response to hypoxia
GO:0007165  signal transduction

Cellular Component

GO:0005901  caveola
GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0044430  cytoskeletal part
GO:0005829  cytosol
GO:0030425  dendrite
GO:0030426  growth cone
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0045121  membrane raft
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0043234  protein complex
GO:0033596  TSC1-TSC2 complex

Molecular Function

GO:0005096  GTPase activator activity
GO:0019902  phosphatase binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity