membrane associated guanylate kinase, WW and PDZ domain containing 2

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Synonym

Aip1, Activin receptor-interacting protein 1, Arip1, Acvrip1, Atrophin-1-interacting protein 1, mKIAA0705, Acvrinp1, Acvri1, Magi-2, Magi2, Membrane-associated guanylate kinase inverted 2, S-SCAM, MAGI-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:123.30 cerebellum:128.90 brain stem:190.70 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:141.90 retina:128.60 eye:30.40 artery/aorta:- vein:- lymphnode:- peripheral blood:43.10 spleen:- thymus:- bone marrow:- adipose:425.40 bone:- skin:7.90
GeneChip nodata
CAGE cerebrum:4.56 cerebellum:- brain stem:4.36 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.43 retina:- eye:- artery/aorta:2.58 vein:- lymphnode:1.86 peripheral blood:- spleen:1.00 thymus:0.67 bone marrow:- adipose:- bone:1.02 skin:2.19
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:30.90 ovary:23 testis:14.80 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.10        lung:-    bladder:- kidney:16.10 pituitary:- thyroid/parathyroid:- adrenal gland:1273.30 pancreas:- breast:6.50 salivary:-
GeneChip nodata
CAGE uterus:2.57 placenta:1.25 prostate:1.16 ovary:2.83 testis:4.13 heart:- muscle:- esophagus:- stomach:2.26 intestine:1.36 colon:1.03     liver/hepato:0.26    lung:2.34 bladder:2.37 kidney:- pituitary:4.33 thyroid/parathyroid:- adrenal gland:2.61 pancreas:1.84 breast:1.12 salivary:-
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_001476581
Gene ID 50791
Unigene ID Mm.332231
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Rat [0]  

Chromosomal Region

5A3  [18,732,864  -  20,210,616]

Gene Family (Interpro ID)

IPR008144  Guanylate kinase
IPR008145  Guanylate kinase/L-type calcium channel
IPR001202  WW/Rsp5/WWP

Link to Pubmed  (Pubmed ID)

10349636
10681527
11042159
11076861
11217851
12466851
12477932
12693553
14529612
14691545
14750953
14988405
15489334
15509766
15579911
15652357
16141072
16141073
16648306
16870733
17114649
17438139
18287559
18799693
20534871
20799038
21198641
21267068
21386911
21931791
22361463
22844512
22849377
23523645
23751499

Gene Ontology  (GO ID)

Biological Process

GO:0032926  negative regulation of activin receptor signaling pathway
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0032516  positive regulation of phosphoprotein phosphatase activity
GO:0002092  positive regulation of receptor internalization
GO:0051291  protein heterooligomerization
GO:0043113  receptor clustering
GO:0007165  signal transduction
GO:0060395  SMAD protein signal transduction

Cellular Component

GO:0030054  cell junction
GO:0005737  cytoplasm
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0043234  protein complex
GO:0045202  synapse
GO:0005923  tight junction

Molecular Function

GO:0031697  beta-1 adrenergic receptor binding
GO:0030165  PDZ domain binding
GO:0019902  phosphatase binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0030159  receptor signaling complex scaffold activity
GO:0004871  signal transducer activity
GO:0046332  SMAD binding
GO:0070699  type II activin receptor binding