disabled homolog 2 (Drosophila) interacting protein

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Synonym

DAB2-interacting protein, 2310011D08Rik, AI480459, Dab2ip, Kiaa1743, KIAA1743, mKIAA1743, MGC144147, Disabled homolog 2-interacting protein

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:222.30 cerebellum:55.30 brain stem:158.90 corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:94.60 retina:64.30 eye:98.80 artery/aorta:- vein:- lymphnode:32.40 peripheral blood:14.40 spleen:- thymus:39.50 bone marrow:25.60 adipose:212.70 bone:125.20 skin:118.80
GeneChip cerebrum:8.42 cerebellum:10.12 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.66 spine:8.46 retina:8.31 eye:7.77 artery/aorta:- vein:8.26 lymphnode:7.04 peripheral blood:- spleen:7.46 thymus:- bone marrow:6.83 adipose:8.26 bone:7.18 skin:8.45
CAGE cerebrum:4.24 cerebellum:- brain stem:3.30 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.05 retina:- eye:- artery/aorta:3.40 vein:- lymphnode:1.64 peripheral blood:- spleen:2.10 thymus:2.22 bone marrow:- adipose:- bone:2.59 skin:3.22
RNA-seq cerebrum:12.73 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:82.80 prostate:30.90 ovary:34.50 testis:22.20 heart:55.80 muscle:284.10 esophagus:- stomach:32.70 intestine:37 colon:35.20     liver/hepato:54.30        lung:120.50    bladder:66.20 kidney:72.50 pituitary:129.20 thyroid/parathyroid:- adrenal gland:- pancreas:37.50 breast:58.80 salivary:108
GeneChip uterus:8.72 placenta:8.22 prostate:8.09 ovary:8.34 testis:7.71 heart:8.90 muscle:8.99 esophagus:- stomach:8.50 intestine:9.06 colon:- liver/hepato:6.70 lung:9 bladder:8.90 kidney:8.03 pituitary:8.81 thyroid/parathyroid:- adrenal gland:8.53 pancreas:7.68 breast:8.27 salivary:9.18
CAGE uterus:3.69 placenta:3.16 prostate:2.90 ovary:3.13 testis:1.80 heart:- muscle:- esophagus:- stomach:3.25 intestine:4.01 colon:4.19     liver/hepato:2.62    lung:4.03 bladder:3.90 kidney:- pituitary:3.47 thyroid/parathyroid:- adrenal gland:3.26 pancreas:2.56 breast:3.50 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.25 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.85        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001114125
Gene ID 69601
Unigene ID Mm.29629
Probe set ID 1433558_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026883

Orthologous Gene

Human[2]  NM_032552, NM_138709
Rat[1]  NM_138710, NM_138709

Chromosomal Region

2B  [35,413,786  -  35,586,514]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR001849  Pleckstrin homology
IPR001936  Ras GTPase-activating protein
IPR008936  Rho GTPase activation protein

Link to Pubmed  (Pubmed ID)

10349636
10922068
11042159
11076861
11217851
11544199
12466851
12477932
12520002
12693553
12877983
14610273
15489334
15747579
16141072
16141073
16629596
17114649
18281285
18799693
19033661
19903888
19948740
20080667
20154697
20648627
21267068
21700930
22743059
23056358
23326475
23413429
23604126
24407031

Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0000185  activation of MAPKKK activity
GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0070059  apoptosis in response to endoplasmic reticulum stress
GO:0007049  cell cycle
GO:0021814  cell motility involved in cerebral cortex radial glia guided migration
GO:0044257  cellular protein catabolic process
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0071347  cellular response to interleukin-1
GO:0071222  cellular response to lipopolysaccharide
GO:0071356  cellular response to tumor necrosis factor
GO:0007252  I-kappaB phosphorylation
GO:0008625  induction of apoptosis via death domain receptors
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0021819  layer formation in the cerebral cortex
GO:0007275  multicellular organismal development
GO:0016525  negative regulation of angiogenesis
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0010596  negative regulation of endothelial cell migration
GO:0042059  negative regulation of epidermal growth factor receptor signaling pathway
GO:0010633  negative regulation of epithelial cell migration
GO:0050680  negative regulation of epithelial cell proliferation
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0048147  negative regulation of fibroblast proliferation
GO:0070317  negative regulation of G0 to G1 transition
GO:0034260  negative regulation of GTPase activity
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043407  negative regulation of MAP kinase activity
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0043553  negative regulation of phosphoinositide 3-kinase activity
GO:0014067  negative regulation of phosphoinositide 3-kinase cascade
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0034261  negative regulation of Ras GTPase activity
GO:0046580  negative regulation of Ras protein signal transduction
GO:0034144  negative regulation of toll-like receptor 4 signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030948  negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0048812  neuron projection morphogenesis
GO:0043065  positive regulation of apoptosis
GO:0071158  positive regulation of cell cycle arrest
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0010976  positive regulation of neuron projection development
GO:0045732  positive regulation of protein catabolic process
GO:0032320  positive regulation of Ras GTPase activity
GO:0090129  positive regulation of synapse maturation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032312  regulation of ARF GTPase activity
GO:0040008  regulation of growth
GO:0043122  regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043254  regulation of protein complex assembly
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0006950  response to stress
GO:0006986  response to unfolded protein
GO:0007165  signal transduction
GO:0035148  tube lumen formation

Cellular Component

GO:0030424  axon
GO:0042995  cell projection
GO:0043025  cell soma
GO:0032809  cell soma membrane
GO:0005737  cytoplasm
GO:0030139  endocytic vesicle
GO:0005622  intracellular
GO:0031235  intrinsic to internal side of plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005123  death receptor binding
GO:0005096  GTPase activator activity
GO:0042802  identical protein binding
GO:0019900  kinase binding
GO:0031434  mitogen-activated protein kinase kinase binding
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0032266  phosphatidylinositol 3-phosphate binding
GO:0070273  phosphatidylinositol-4-phosphate binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0047485  protein N-terminus binding
GO:0051721  protein phosphatase 2A binding
GO:0005099  Ras GTPase activator activity
GO:0017124  SH3 domain binding
GO:0043184  vascular endothelial growth factor receptor 2 binding