endoplasmic reticulum aminopeptidase 1

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Synonym

A-LAP, PILSA, PILS-AP, VEGF-induced aminopeptidase, Arts1, Aminopeptidase PILS, Adipocyte-derived leucine aminopeptidase precursor, PILSAP, Appils, ARTS-1, ERAAP

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:15.60 cerebellum:55.30 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:378.30 retina:64.30 eye:- artery/aorta:168.80 vein:- lymphnode:32.40 peripheral blood:445.70 spleen:65.80 thymus:158.10 bone marrow:12.80 adipose:- bone:50.10 skin:23.80
GeneChip cerebrum:4.65 cerebellum:4.10 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.48 spine:4.93 retina:5.24 eye:6.06 artery/aorta:- vein:5.76 lymphnode:8.39 peripheral blood:- spleen:7.36 thymus:- bone marrow:7.21 adipose:7.52 bone:7.08 skin:6.27
CAGE cerebrum:1.90 cerebellum:- brain stem:2.18 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.48 retina:- eye:- artery/aorta:3.75 vein:- lymphnode:4.33 peripheral blood:- spleen:3.47 thymus:3.58 bone marrow:- adipose:- bone:3.46 skin:2.98
RNA-seq cerebrum:1.46 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:92.60 ovary:34.50 testis:14.80 heart:37.20 muscle:- esophagus:- stomach:65.50 intestine:184.90 colon:35.20     liver/hepato:54.30        lung:100.40    bladder:- kidney:8.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:56.30 breast:114.30 salivary:54
GeneChip uterus:7.22 placenta:7.49 prostate:7.79 ovary:7.08 testis:4.51 heart:6.89 muscle:6.64 esophagus:- stomach:7.03 intestine:8.34 colon:- liver/hepato:8.29 lung:7.43 bladder:7.09 kidney:6.54 pituitary:7.52 thyroid/parathyroid:- adrenal gland:6.72 pancreas:5.69 breast:7.47 salivary:6.54
CAGE uterus:3.59 placenta:2.91 prostate:3.39 ovary:3.28 testis:0.75 heart:- muscle:- esophagus:- stomach:2.95 intestine:4.07 colon:4.09     liver/hepato:4.22    lung:3.64 bladder:3.31 kidney:- pituitary:3.61 thyroid/parathyroid:- adrenal gland:3.35 pancreas:2.90 breast:3.53 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.89 esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.06        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_030711
Gene ID 80898
Unigene ID Mm.83526
Probe set ID 1416942_at  [Mouse430_2]
Ensembl ID ENSMUSG00000021583

Orthologous Gene

Human[4]  NM_001040458, NM_001198541, NM_016442
Rat[1]  NM_030836, NM_001198541, NM_016442

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10349636
11042159
11076861
11217851
11964289
12368856
12466851
12477932
15187024
16141072
16141073
16299505
16505142
16602821
16754858
16824192
17088086
17128277
17277129
17385722
18587399
18941218
20173027
20562862
21252114
21267068
21531727
21572029
21677750
22522492
23386199
23863903
23894499
24248368
24504800
24688025

Gene Ontology  (GO ID)

Biological Process

GO:0006509  membrane protein ectodomain proteolysis
GO:0008152  metabolic process
GO:0045766  positive regulation of angiogenesis
GO:0006508  proteolysis

Cellular Component

GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0005788  endoplasmic reticulum lumen
GO:0005576  extracellular region
GO:0016021  integral to membrane
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane

Molecular Function

GO:0004177  aminopeptidase activity
GO:0016787  hydrolase activity
GO:0005138  interleukin-6 receptor binding
GO:0046872  metal ion binding
GO:0008235  metalloexopeptidase activity
GO:0008237  metallopeptidase activity
GO:0008233  peptidase activity
GO:0005164  tumor necrosis factor receptor binding
GO:0008270  zinc ion binding