sphingosine kinase 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:73.70 spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:39 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:164.70 heart:19.40 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_133386
Gene ID 170897
Unigene ID Rn.18522
Probe set ID -
Ensembl ID ENSRNOG00000010626

Orthologous Gene

Human[4]  NM_001142601, NM_001142602, NM_021972, NM_182965
Mouse[2]  NM_001172472, NM_001172473, NM_001172475, NM_011451, NM_025367

Chromosomal Region

10q32.3  [106,642,672  -  106,645,566]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

11560121
12477932
15289497
15310762
15314148
15585953
15715670
15741218
15855330
16135093
16313513
16319132
16888242
16956968
16959847
16980623
17158340
17164439
17200676
17265031
17316399
17325039
18028875
18552482
18675457
18723875
18761669
18805787
19357361
19797403
20371493
21310085
21660956
21887342
21998146
22155656
22251137
23085271
23817990

Gene Ontology  (GO ID)

Biological Process

GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0001568  blood vessel development
GO:0007420  brain development
GO:0019722  calcium-mediated signaling
GO:0071363  cellular response to growth factor stimulus
GO:0070301  cellular response to hydrogen peroxide
GO:0009267  cellular response to starvation
GO:0019371  cyclooxygenase pathway
GO:0007565  female pregnancy
GO:0006954  inflammatory response
GO:0043066  negative regulation of apoptosis
GO:0045766  positive regulation of angiogenesis
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0048146  positive regulation of fibroblast proliferation
GO:0045931  positive regulation of mitotic cell cycle
GO:0010976  positive regulation of neuron projection development
GO:0001956  positive regulation of neurotransmitter secretion
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0031398  positive regulation of protein ubiquitination
GO:0045987  positive regulation of smooth muscle contraction
GO:0032651  regulation of interleukin-1 beta production
GO:0010803  regulation of tumor necrosis factor-mediated signaling pathway
GO:0014075  response to amine stimulus
GO:0033198  response to ATP
GO:0070555  response to interleukin-1
GO:0032026  response to magnesium ion
GO:0014070  response to organic cyclic substance
GO:0032570  response to progesterone stimulus
GO:0006670  sphingosine metabolic process

Cellular Component

GO:0030424  axon
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0008021  synaptic vesicle

Molecular Function

GO:0005524  ATP binding
GO:0005516  calmodulin binding
GO:0017050  D-erythro-sphingosine kinase activity
GO:0004143  diacylglycerol kinase activity
GO:0003677  DNA binding
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0051721  protein phosphatase 2A binding
GO:0008481  sphinganine kinase activity