synaptic Ras GTPase activating protein 1 homolog (rat)

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Synonym

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Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:122.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.61 cerebellum:5.27 brain stem:5.52 corpus callosum/glia:- pineal gland:- peripheral nerve:5.59 spine:- retina:- eye:5.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:5.49 thymus:5.33 bone marrow:5.74 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:75.90 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:13.30        lung:-    bladder:- kidney:- pituitary:177.70 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:5.43 muscle:5.63 esophagus:- stomach:- intestine:5.13 colon:5.31 liver/hepato:- lung:- bladder:- kidney:5.36 pituitary:5.39 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_181092
Gene ID 192117
Unigene ID Rn.99081
Probe set ID AF058789_at  [RG_U34A]
Ensembl ID ENSRNOG00000000483

Orthologous Gene

Human[1]  NM_006772
Mouse[1]  NM_006772

Chromosomal Region

20p12  [5,178,523  -  5,208,449]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR001849  Pleckstrin homology
IPR001936  Ras GTPase-activating protein
IPR008936  Rho GTPase activation protein

Link to Pubmed  (Pubmed ID)

9581761
9620694
11278737
11489946
12063253
12951199
14970204
15014045
15312654
15500970
16054660
16427633
18417361
18824155
21382555
21736925
22717267
22871113

Gene Ontology  (GO ID)

Biological Process

GO:0016358  dendrite development
GO:0050771  negative regulation of axonogenesis
GO:0043524  negative regulation of neuron apoptosis
GO:0046580  negative regulation of Ras protein signal transduction
GO:0007389  pattern specification process
GO:0032320  positive regulation of Ras GTPase activity
GO:0007265  Ras protein signal transduction
GO:0043113  receptor clustering
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0043408  regulation of MAPKKK cascade
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0050803  regulation of synapse structure and activity
GO:0048167  regulation of synaptic plasticity
GO:0007165  signal transduction
GO:0008542  visual learning

Cellular Component

GO:0030054  cell junction
GO:0005737  cytoplasm
GO:0043198  dendritic shaft
GO:0005622  intracellular
GO:0031235  intrinsic to internal side of plasma membrane
GO:0016020  membrane
GO:0014069  postsynaptic density

Molecular Function

GO:0005096  GTPase activator activity
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0005097  Rab GTPase activator activity
GO:0005099  Ras GTPase activator activity
GO:0017124  SH3 domain binding