carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:47.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:156 thymus:245.80 bone marrow:- adipose:147.20 bone:78.10 skin:-
GeneChip cerebrum:6.33 cerebellum:6.28 brain stem:6.83 corpus callosum/glia:- pineal gland:- peripheral nerve:6.55 spine:- retina:- eye:6.59 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.33 thymus:6.18 bone marrow:6.68 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:477.90 prostate:151.80 ovary:- testis:- heart:213.30 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:26.60        lung:-    bladder:- kidney:127.60 pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:113.80 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.43 muscle:6.27 esophagus:- stomach:- intestine:6.23 colon:5.97 liver/hepato:- lung:- bladder:- kidney:6.15 pituitary:6.15 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001105710
Gene ID 24240
Unigene ID Rn.19416
Probe set ID AB007768_at  [RG_U34A]
Ensembl ID ENSRNOG00000026474

Orthologous Gene

Human[1]  NM_004341
Mouse[2]  NM_023525

Chromosomal Region

6q14  [25,272,416  -  25,296,266]

Gene Family (Interpro ID)

IPR006220  Anthranilate synthase component II/delta crystallin
IPR002082  Aspartate carbamoyltransferase, eukaryotic
IPR006130  Aspartate/ornithine carbamoyltransferase
IPR011761  ATP-grasp fold
IPR013651  ATP-grasp fold, RimK-type
IPR001317  Carbamoyl phosphate synthase, GATase domain
IPR005481  Carbamoyl phosphate synthase, large subunit, N-terminal
IPR005479  Carbamoyl phosphate synthetase, large subunit, ATP-binding
IPR000991  Glutamine amidotransferase class-I, C-terminal
IPR011702  Glutamine amidotransferase superfamily
IPR017926  Glutamine amidotransferase type 1
IPR011059  Metal-dependent hydrolase, composite domain
IPR011607  MGS-like
IPR013817  Pre-ATP-grasp fold
IPR016185  PreATP-grasp-like fold

Link to Pubmed  (Pubmed ID)

12803
26565
1148171
1476792
1673139
2353918
2474281
2864015
2888462
2914957
3973436
6020217
6030068
6149265
8533158
8548770
9869632
10659854
13618893
13671431
14160653
15096496
18515330

Gene Ontology  (GO ID)

Biological Process

GO:0006207  'de novo' pyrimidine base biosynthetic process
GO:0070409  carbamoyl phosphate biosynthetic process
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0017144  drug metabolic process
GO:0009790  embryonic development
GO:0007565  female pregnancy
GO:0006543  glutamine catabolic process
GO:0006541  glutamine metabolic process
GO:0007595  lactation
GO:0031100  organ regeneration
GO:0014075  response to amine stimulus
GO:0031000  response to caffeine
GO:0051414  response to cortisol stimulus
GO:0033574  response to testosterone stimulus
GO:0006228  UTP biosynthetic process

Cellular Component

GO:0042995  cell projection
GO:0043025  cell soma
GO:0005829  cytosol
GO:0016363  nuclear matrix
GO:0005634  nucleus
GO:0043234  protein complex
GO:0043195  terminal button

Molecular Function

GO:0016597  amino acid binding
GO:0004070  aspartate carbamoyltransferase activity
GO:0005524  ATP binding
GO:0004088  carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151  dihydroorotase activity
GO:0019899  enzyme binding
GO:0042802  identical protein binding
GO:0046872  metal ion binding