ret proto-oncogene

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Synonym

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Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:83.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:221.20 spine:- retina:- eye:71.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.65 cerebellum:6.57 brain stem:7.07 corpus callosum/glia:- pineal gland:- peripheral nerve:6.34 spine:- retina:- eye:6.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.87 thymus:6.80 bone marrow:6.88 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:75.90 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:50.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.82 muscle:6.92 esophagus:- stomach:- intestine:6.63 colon:6.49 liver/hepato:- lung:- bladder:- kidney:6.73 pituitary:6.41 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001110099
Gene ID 24716
Unigene ID Rn.93200
Probe set ID AF042830_at  [RG_U34A]
Ensembl ID ENSRNOG00000014751

Orthologous Gene

Human[5]  NM_020630, NM_020975
Mouse[2]  NM_001080780, NM_009050

Chromosomal Region

4q42  [154,448,662  -  154,491,103]

Gene Family (Interpro ID)

IPR002126  Cadherin
IPR015919  Cadherin-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR016249  Tyrosine-protein kinase, Ret receptor
IPR015777  Tyrosine-protein kinase, Ret receptor-like
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7647468
9582449
10407114
10407179
11328649
12091387
12210101
12527893
12920301
14555660
15115663
15302866
15837122
16269310
16525057
16569669
16650834
16672314
16738479
16773224
16818623
17183535
17380130
17538205
18317952
18501516
18652760
18668157
18753381
18845535
19133164
19551609
19719936
20392937
20533997
20682772
20877310
21134561
22128160
23413818
23872421

Gene Ontology  (GO ID)

Biological Process

GO:0071300  cellular response to retinoic acid
GO:0001838  embryonic epithelial tube formation
GO:0048484  enteric nervous system development
GO:0007156  homophilic cell adhesion
GO:0060384  innervation
GO:0000165  MAPKKK cascade
GO:0033619  membrane protein proteolysis
GO:0007399  nervous system development
GO:0001755  neural crest cell migration
GO:0007158  neuron adhesion
GO:0030182  neuron differentiation
GO:0042551  neuron maturation
GO:0033630  positive regulation of cell adhesion mediated by integrin
GO:0030335  positive regulation of cell migration
GO:0045793  positive regulation of cell size
GO:0014042  positive regulation of neuron maturation
GO:0010976  positive regulation of neuron projection development
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0050770  regulation of axonogenesis
GO:0030155  regulation of cell adhesion
GO:0042493  response to drug
GO:0048265  response to pain
GO:0060041  retina development in camera-type eye
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0001657  ureteric bud development

Cellular Component

GO:0010008  endosome membrane
GO:0005887  integral to plasma membrane
GO:0045121  membrane raft

Molecular Function

GO:0005524  ATP binding
GO:0005509  calcium ion binding
GO:0003674  molecular_function
GO:0004713  protein tyrosine kinase activity