fibroblast growth factor receptor 2

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:119.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:106.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:294.40 bone:78.10 skin:-
GeneChip cerebrum:7.01 cerebellum:6.77 brain stem:6.90 corpus callosum/glia:- pineal gland:- peripheral nerve:6.60 spine:- retina:- eye:7.61 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:7.02 thymus:6.91 bone marrow:7.07 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:119.50 prostate:189.80 ovary:342.30 testis:- heart:155.10 muscle:- esophagus:- stomach:- intestine:628 colon:-     liver/hepato:-        lung:101.30    bladder:- kidney:- pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:7.07 muscle:7.23 esophagus:- stomach:- intestine:6.86 colon:6.80 liver/hepato:- lung:- bladder:- kidney:6.97 pituitary:6.92 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_012712
Gene ID 25022
Unigene ID Rn.12732
Probe set ID L19107_s_at  [RG_U34A]
Ensembl ID ENSRNOG00000016374

Orthologous Gene

Human[37]  NM_000141, NM_001144913, NM_001144914, NM_001144915, NM_001144916, NM_001144917, NM_001144918, NM_001144919, NM_022970
Mouse[3]  NM_010207, NM_201601, NM_001144914, NM_001144915, NM_001144916, NM_001144917, NM_001144918, NM_001144919, NM_022970

Chromosomal Region

1q37  [189,482,977  -  189,589,279]

Gene Family (Interpro ID)

IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7668257
7803853
8333865
8875318
8889548
9018118
9285567
9528792
9537256
10602477
11042206
11069376
11593393
11834506
11891329
12111699
12397076
12608893
12828933
12947022
14645542
14695195
15065023
15126509
15282342
15292181
15601847
15614790
15684416
16158432
16856175
16963563
16969861
17243131
17306351
17482184
17494997
17525745
17529967
17529973
17708356
18039182
18247426
18285324
18363829
18552176
18785201
19053057
19103595
19410646
19610084
19624690
20640597
21397175
21691921
21994076
23564461

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007409  axonogenesis
GO:0060348  bone development
GO:0030282  bone mineralization
GO:0060349  bone morphogenesis
GO:0060667  branch elongation involved in salivary gland morphogenesis
GO:0060670  branching involved in embryonic placenta morphogenesis
GO:0060442  branching involved in prostate gland morphogenesis
GO:0060445  branching involved in salivary gland morphogenesis
GO:0048755  branching morphogenesis of a nerve
GO:0060449  bud elongation involved in lung branching
GO:0045165  cell fate commitment
GO:0007267  cell-cell signaling
GO:0060365  coronal suture morphogenesis
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0048557  embryonic digestive tract morphogenesis
GO:0048568  embryonic organ development
GO:0048562  embryonic organ morphogenesis
GO:0009880  embryonic pattern specification
GO:0048730  epidermis morphogenesis
GO:0030855  epithelial cell differentiation
GO:0050673  epithelial cell proliferation
GO:0060664  epithelial cell proliferation involved in salivary gland morphogenesis
GO:0001837  epithelial to mesenchymal transition
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0060595  fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0022612  gland morphogenesis
GO:0048565  gut development
GO:0031069  hair follicle morphogenesis
GO:0001701  in utero embryonic development
GO:0042472  inner ear morphogenesis
GO:0032808  lacrimal gland development
GO:0060601  lateral sprouting from an epithelium
GO:0070307  lens fiber cell development
GO:0060174  limb bud formation
GO:0048286  lung alveolus development
GO:0030324  lung development
GO:0060463  lung lobe morphogenesis
GO:0060484  lung-associated mesenchyme development
GO:0060615  mammary gland bud formation
GO:0003149  membranous septum morphogenesis
GO:0048762  mesenchymal cell differentiation
GO:0060915  mesenchymal cell differentiation involved in lung development
GO:0060916  mesenchymal cell proliferation involved in lung development
GO:0048333  mesodermal cell differentiation
GO:0030901  midbrain development
GO:0016331  morphogenesis of embryonic epithelium
GO:0035264  multicellular organism growth
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045839  negative regulation of mitosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0021847  neuroblast division in the ventricular zone
GO:0007528  neuromuscular junction development
GO:0042476  odontogenesis
GO:0021769  orbitofrontal cortex development
GO:0035265  organ growth
GO:0009887  organ morphogenesis
GO:0030916  otic vesicle formation
GO:0003148  outflow tract septum morphogenesis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0060045  positive regulation of cardiac muscle cell proliferation
GO:0045787  positive regulation of cell cycle
GO:0051781  positive regulation of cell division
GO:0008284  positive regulation of cell proliferation
GO:0050679  positive regulation of epithelial cell proliferation
GO:0060501  positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043410  positive regulation of MAPKKK cascade
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0010518  positive regulation of phospholipase activity
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0009791  post-embryonic development
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523  prostate epithelial cord elongation
GO:0060512  prostate gland morphogenesis
GO:0046777  protein amino acid autophosphorylation
GO:0021860  pyramidal neuron development
GO:0060687  regulation of branching involved in prostate gland morphogenesis
GO:0010453  regulation of cell fate commitment
GO:0042127  regulation of cell proliferation
GO:0050678  regulation of epithelial cell proliferation
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0040036  regulation of fibroblast growth factor receptor signaling pathway
GO:0060688  regulation of morphogenesis of a branching structure
GO:0040014  regulation of multicellular organism growth
GO:0051150  regulation of smooth muscle cell differentiation
GO:0008589  regulation of smoothened signaling pathway
GO:0048608  reproductive structure development
GO:0060529  squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489  synaptic vesicle transport
GO:0001657  ureteric bud development
GO:0055010  ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0005938  cell cortex
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0060076  excitatory synapse
GO:0031012  extracellular matrix
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0017134  fibroblast growth factor binding
GO:0005007  fibroblast growth factor receptor activity
GO:0042802  identical protein binding
GO:0042803  protein homodimerization activity