FYN oncogene related to SRC, FGR, YES

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:119.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:73.70 spine:- retina:- eye:248.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:312 thymus:- bone marrow:- adipose:- bone:39 skin:-
GeneChip cerebrum:8.08 cerebellum:8.37 brain stem:8.09 corpus callosum/glia:- pineal gland:- peripheral nerve:8.01 spine:- retina:- eye:6.59 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:8.60 thymus:8.34 bone marrow:7.43 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:151.80 ovary:114.10 testis:82.30 heart:58.20 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:152    bladder:- kidney:127.60 pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:7.49 muscle:6.53 esophagus:- stomach:- intestine:6.37 colon:6.64 liver/hepato:- lung:- bladder:- kidney:6.74 pituitary:7.45 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_012755
Gene ID 25150
Unigene ID Rn.19361
Probe set ID rc_AI009191_at  [RG_U34A]
Ensembl ID ENSRNOG00000000596

Orthologous Gene

Human[8]  NM_001242779, NM_002037, NM_153047, NM_153048
Mouse[6]  NM_001122892, NM_001122893, NM_008054, NM_153048

Chromosomal Region

20q12  [43,501,853  -  43,695,567]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR013315  Spectrin alpha chain, SH3 domain
IPR020473  Src homology-3, region
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1280324
1361685
1372996
1722201
2062320
7935483
8103744
8264796
8402898
8761480
8870703
9460655
9551931
9892651
10366594
11181827
11226670
11236902
11245687
11943848
12007793
12231245
12353920
12419528
12524444
12618293
12670706
12736333
12778121
12882964
14531861
14625475
14697322
14741357
14999081
15282299
15380937
15579503
15708437
15731459
16860569
17658244
18089558
18469807
18682436
18701695
18922801
19109931
19115405
19166962
19178193
19441121
19625508
19652227
19888448
20569495
22057277
22433866
22437915
22802969
22833681
24003228

Gene Ontology  (GO ID)

Biological Process

GO:0050798  activated T cell proliferation
GO:0071363  cellular response to growth factor stimulus
GO:0071375  cellular response to peptide hormone stimulus
GO:0048813  dendrite morphogenesis
GO:0050966  detection of mechanical stimulus involved in sensory perception of pain
GO:0030900  forebrain development
GO:0035235  ionotropic glutamate receptor signaling pathway
GO:0010629  negative regulation of gene expression
GO:0042177  negative regulation of protein catabolic process
GO:0001764  neuron migration
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0010976  positive regulation of neuron projection development
GO:0046777  protein amino acid autophosphorylation
GO:0008360  regulation of cell shape
GO:0042493  response to drug
GO:0045471  response to ethanol
GO:0050852  T cell receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0005768  endosome
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0005739  mitochondrion
GO:0005886  plasma membrane
GO:0014069  postsynaptic density

Molecular Function

GO:0005524  ATP binding
GO:0042609  CD4 receptor binding
GO:0042610  CD8 receptor binding
GO:0046875  ephrin receptor binding
GO:0001948  glycoprotein binding
GO:0042802  identical protein binding
GO:0046872  metal ion binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0051428  peptide hormone receptor binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0005102  receptor binding
GO:0042608  T cell receptor binding
GO:0015631  tubulin binding