arachidonate 12-lipoxygenase

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:39 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:13.30        lung:50.70    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001105798
Gene ID 287454
Unigene ID Rn.66513
Probe set ID -
Ensembl ID ENSRNOG00000027037

Orthologous Gene

Human[1]  NM_000697
Mouse[2]  NM_007440

Chromosomal Region

10q24  [57,080,603  -  57,092,874]

Gene Family (Interpro ID)

IPR008976  Lipase/lipooxygenase, PLAT/LH2
IPR000907  Lipoxygenase
IPR001024  Lipoxygenase, LH2
IPR001885  Lipoxygenase, mammalian

Link to Pubmed  (Pubmed ID)

7511046
7624992
7679252
8304420
8643560
9500559
10733500
12432922
12477932
14532840
14654968
14669797
14767568
15105833
15123652
15450084
15518705
15564577
15623566
15626691
15896353
16029322
16040349
16118253
16199435
16445702
18640486
18680775
18780776
19095999
19103735
19117969
19235890
19282568
20554417
20978234
21285403

Gene Ontology  (GO ID)

Biological Process

GO:0007568  aging
GO:0019369  arachidonic acid metabolic process
GO:0006928  cellular component movement
GO:0071396  cellular response to lipid
GO:0019395  fatty acid oxidation
GO:0006691  leukotriene metabolic process
GO:0043651  linoleic acid metabolic process
GO:0019372  lipoxygenase pathway
GO:0043066  negative regulation of apoptosis
GO:0010656  negative regulation of muscle cell apoptosis
GO:0045766  positive regulation of angiogenesis
GO:0043065  positive regulation of apoptosis
GO:0043280  positive regulation of caspase activity
GO:0045785  positive regulation of cell adhesion
GO:0010942  positive regulation of cell death
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0045603  positive regulation of endothelial cell differentiation
GO:0010595  positive regulation of endothelial cell migration
GO:0010628  positive regulation of gene expression
GO:0051901  positive regulation of mitochondrial depolarization
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045909  positive regulation of vasodilation

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0042383  sarcolemma

Molecular Function

GO:0004052  arachidonate 12-lipoxygenase activity
GO:0005506  iron ion binding
GO:0016165  lipoxygenase activity