paired box 2

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001106361
Gene ID 293992
Unigene ID Rn.137112
Probe set ID -
Ensembl ID ENSRNOG00000014253

Orthologous Gene

Human[10]  NM_000278, NM_003987, NM_003988, NM_003989, NM_003990
Mouse[1]  NM_011037, NM_003987, NM_003988, NM_003989, NM_003990

Chromosomal Region

1q54  [249,804,055  -  249,895,306]

Gene Family (Interpro ID)

IPR009057  Homeodomain-like
IPR001523  Paired box protein, N-terminal
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

7937920
11262416
12057921
12444203
15149326
15569307
18489730
18639218
20486844
21778682
23107969
23503776

Gene Ontology  (GO ID)

Biological Process

GO:0007568  aging
GO:0048854  brain morphogenesis
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0043010  camera-type eye development
GO:0001709  cell fate determination
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0071333  cellular response to glucose stimulus
GO:0070301  cellular response to hydrogen peroxide
GO:0071260  cellular response to mechanical stimulus
GO:0071300  cellular response to retinoic acid
GO:0090102  cochlea development
GO:0090103  cochlea morphogenesis
GO:0010001  glial cell differentiation
GO:0042472  inner ear morphogenesis
GO:0001822  kidney development
GO:0060231  mesenchymal to epithelial transition
GO:0003337  mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007501  mesodermal cell fate specification
GO:0001823  mesonephros development
GO:0001656  metanephros development
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0045918  negative regulation of cytolysis
GO:0043069  negative regulation of programmed cell death
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0001843  neural tube closure
GO:0002072  optic cup morphogenesis involved in camera-type eye development
GO:0021554  optic nerve development
GO:0021631  optic nerve morphogenesis
GO:0021633  optic nerve structural organization
GO:0048513  organ development
GO:0055114  oxidation reduction
GO:0031016  pancreas development
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0008284  positive regulation of cell proliferation
GO:0050679  positive regulation of epithelial cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0048793  pronephros development
GO:0043491  protein kinase B signaling cascade
GO:0042981  regulation of apoptosis
GO:0043067  regulation of programmed cell death
GO:0031667  response to nutrient levels
GO:0003406  retinal pigment epithelium development
GO:0048863  stem cell differentiation
GO:0006351  transcription, DNA-dependent
GO:0001657  ureteric bud development
GO:0001655  urogenital system development
GO:0021650  vestibulocochlear nerve formation

Cellular Component

GO:0034451  centriolar satellite
GO:0005764  lysosome
GO:0005815  microtubule organizing center
GO:0005634  nucleus
GO:0043234  protein complex
GO:0032993  protein-DNA complex

Molecular Function

GO:0070742  C2H2 zinc finger domain binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0043565  sequence-specific DNA binding
GO:0016175  superoxide-generating NADPH oxidase activity
GO:0003700  transcription factor activity