intersectin 1 (SH3 domain protein)

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:71.10 artery/aorta:357.10 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:- ovary:- testis:- heart:77.60 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:66.50        lung:-    bladder:- kidney:63.80 pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_019227
Gene ID 29491
Unigene ID Rn.48657
Probe set ID -
Ensembl ID ENSRNOG00000002001

Orthologous Gene

Human[4]  NM_001001132, NM_003024
Mouse[7]  NM_001110275, NM_001110276, NM_010587

Chromosomal Region

11q11  [31,721,528  -  31,901,963]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein
IPR002048  Calcium-binding EF-hand
IPR018249  EF-HAND 2
IPR018248  EF-Hand domain
IPR001849  Pleckstrin homology
IPR013315  Spectrin alpha chain, SH3 domain
IPR020473  Src homology-3, region

Link to Pubmed  (Pubmed ID)

10373452
11584276
16394100
16903783
19258322
20448150
21088884
23633571

Gene Ontology  (GO ID)

Biological Process

GO:0006897  endocytosis
GO:0006887  exocytosis
GO:0043524  negative regulation of neuron apoptosis
GO:0043085  positive regulation of catalytic activity
GO:0042327  positive regulation of phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0030054  cell junction
GO:0005905  coated pit
GO:0030139  endocytic vesicle
GO:0030027  lamellipodium
GO:0043005  neuron projection
GO:0005886  plasma membrane
GO:0045202  synapse

Molecular Function

GO:0005509  calcium ion binding
GO:0019209  kinase activator activity
GO:0070064  proline-rich region binding
GO:0005515  protein binding
GO:0032947  protein complex scaffold