proprotein convertase subtilisin/kexin type 9

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:104.70 colon:289.90     liver/hepato:106.40        lung:-    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_199253
Gene ID 298296
Unigene ID Rn.19195
Probe set ID -
Ensembl ID ENSRNOG00000006280

Orthologous Gene

Human[1]  NM_174936
Mouse[1]  NM_153565

Chromosomal Region

5q34  [127,501,476  -  127,524,289]

Gene Family (Interpro ID)

IPR015500  Peptidase S8, subtilisin-related
IPR000209  Peptidase S8/S53, subtilisin/kexin/sedolisin
IPR010259  Proteinase inhibitor I9, subtilisin propeptide
IPR009020  Proteinase inhibitor, propeptide

Link to Pubmed  (Pubmed ID)

10964518
12477932
12552124
12552133
12730697
14622975
14727179
15178557
15772090
16407292
16462892
16554528
16619215
17051583
17380167
18054320
18054775
19008317
21763412

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0032869  cellular response to insulin stimulus
GO:0009267  cellular response to starvation
GO:0042632  cholesterol homeostasis
GO:0008203  cholesterol metabolic process
GO:0006917  induction of apoptosis
GO:0001822  kidney development
GO:0042157  lipoprotein metabolic process
GO:0001889  liver development
GO:0032802  low-density lipoprotein receptor catabolic process
GO:0032799  low-density lipoprotein receptor metabolic process
GO:0007041  lysosomal transport
GO:0043086  negative regulation of catalytic activity
GO:0010989  negative regulation of low-density lipoprotein particle clearance
GO:0001920  negative regulation of receptor recycling
GO:0022008  neurogenesis
GO:0030182  neuron differentiation
GO:0006644  phospholipid metabolic process
GO:0043525  positive regulation of neuron apoptosis
GO:0002092  positive regulation of receptor internalization
GO:0016540  protein autoprocessing
GO:0016485  protein processing
GO:0006508  proteolysis
GO:0032803  regulation of low-density lipoprotein receptor catabolic process
GO:0043523  regulation of neuron apoptosis
GO:0010469  regulation of receptor activity
GO:0006641  triglyceride metabolic process

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005769  early endosome
GO:0005783  endoplasmic reticulum
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005794  Golgi apparatus
GO:0005770  late endosome
GO:0005764  lysosome
GO:0048471  perinuclear region of cytoplasm
GO:0005791  rough endoplasmic reticulum

Molecular Function

GO:0034185  apolipoprotein binding
GO:0034190  apolipoprotein receptor binding
GO:0042802  identical protein binding
GO:0030169  low-density lipoprotein binding
GO:0050750  low-density lipoprotein receptor binding
GO:0043621  protein self-association
GO:0004252  serine-type endopeptidase activity
GO:0019871  sodium channel inhibitor activity
GO:0034189  very-low-density lipoprotein binding
GO:0070326  very-low-density lipoprotein receptor binding