ataxia telangiectasia mutated homolog (human)

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:71.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:- testis:247 heart:19.40 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:13.30        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:113.80 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_001068795
Gene ID 300711
Unigene ID Rn.214048
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Mouse [0]  

Chromosomal Region

8q24  [56,894,746  -  56,996,565]

Gene Family (Interpro ID)

IPR016024  Armadillo-type fold
IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic
IPR014009  PIK-related kinase
IPR003151  PIK-related kinase, FAT
IPR011009  Protein kinase-like domain

Link to Pubmed  (Pubmed ID)

10748873
10822387
11200774
11751435
11852039
12588868
12915485
14983937
15863839
16498454
16520463
16601750
16651613
16997395
17064299
17084711
17164260
18162465
18381943
18534819
19147782
19151707
19208651
19450511
19557000
19657808
20111719
20213763
21186350
21533982
22505033
23532176
24610783

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0007420  brain development
GO:0007050  cell cycle arrest
GO:0071480  cellular response to gamma radiation
GO:0000077  DNA damage checkpoint
GO:0006975  DNA damage induced protein phosphorylation
GO:0008630  DNA damage response, signal transduction resulting in induction of apoptosis
GO:0006281  DNA repair
GO:0007292  female gamete generation
GO:0031572  G2/M transition DNA damage checkpoint
GO:0007507  heart development
GO:0071044  histone mRNA catabolic process
GO:0016572  histone phosphorylation
GO:0042159  lipoprotein catabolic process
GO:0007094  mitotic cell cycle spindle assembly checkpoint
GO:0043066  negative regulation of apoptosis
GO:0030889  negative regulation of B cell proliferation
GO:0051402  neuron apoptosis
GO:0048599  oocyte development
GO:0018105  peptidyl-serine phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0043517  positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525  positive regulation of neuron apoptosis
GO:0002331  pre-B cell allelic exclusion
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0051726  regulation of cell cycle
GO:0006974  response to DNA damage stimulus
GO:0001666  response to hypoxia
GO:0010212  response to ionizing radiation
GO:0001756  somitogenesis
GO:0000723  telomere maintenance

Cellular Component

GO:0000781  chromosome, telomeric region
GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0005819  spindle

Molecular Function

GO:0016303  1-phosphatidylinositol-3-kinase activity
GO:0005524  ATP binding
GO:0004677  DNA-dependent protein kinase activity
GO:0035174  histone serine kinase activity
GO:0032403  protein complex binding
GO:0046983  protein dimerization activity
GO:0004672  protein kinase activity
GO:0047485  protein N-terminus binding
GO:0004674  protein serine/threonine kinase activity