Rap guanine nucleotide exchange factor (GEF) 2

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:122.90 bone marrow:- adipose:- bone:39 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:- ovary:114.10 testis:- heart:116.30 muscle:- esophagus:- stomach:- intestine:209.30 colon:-     liver/hepato:13.30        lung:50.70    bladder:- kidney:- pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_227301
Gene ID 310533
Unigene ID Rn.23121
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Mouse [0]  

Chromosomal Region

2q32  [170,472,420  -  170,587,987]

Gene Family (Interpro ID)

IPR000595  Cyclic nucleotide-binding
IPR018490  Cyclic nucleotide-binding-like
IPR014710  RmlC-like jelly roll fold

Link to Pubmed  (Pubmed ID)

10548487
10801446
12391161
17724123
23800469
24567337

Gene Ontology  (GO ID)

Biological Process

GO:0071320  cellular response to cAMP
GO:0071321  cellular response to cGMP
GO:0008285  negative regulation of cell proliferation
GO:0050774  negative regulation of dendrite morphogenesis
GO:0043950  positive regulation of cAMP-mediated signaling
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0045860  positive regulation of protein kinase activity
GO:0032854  positive regulation of Rap GTPase activity
GO:0032320  positive regulation of Ras GTPase activity
GO:0048167  regulation of synaptic plasticity
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005622  intracellular
GO:0005770  late endosome
GO:0016020  membrane
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0031697  beta-1 adrenergic receptor binding
GO:0030552  cAMP binding
GO:0030553  cGMP binding
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0030165  PDZ domain binding
GO:0019901  protein kinase binding
GO:0046582  Rap GTPase activator activity
GO:0017034  Rap guanyl-nucleotide exchange factor activity
GO:0005088  Ras guanyl-nucleotide exchange factor activity
GO:0050699  WW domain binding