secreted frizzled-related protein 2

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:294.40 bone:39 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:101.30    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_227314
Gene ID 310552
Unigene ID Rn.102416
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Mouse [0]  

Chromosomal Region

2q34  [175,479,320  -  175,486,864]

Gene Family (Interpro ID)

IPR020067  Frizzled-like domain
IPR001134  Netrin domain
IPR018933  Netrin module, non-TIMP type
IPR008993  TIMP-like, OB-fold

Link to Pubmed  (Pubmed ID)

12477932
14561758
16077992
17251350
17341692
19109969
21078975
22290867
23085770

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0006915  apoptosis
GO:0060349  bone morphogenesis
GO:0007420  brain development
GO:0003214  cardiac left ventricle morphogenesis
GO:0051216  cartilage development
GO:0008219  cell death
GO:0031668  cellular response to extracellular stimulus
GO:0071481  cellular response to X-ray
GO:0002063  chondrocyte development
GO:0030199  collagen fibril organization
GO:0060028  convergent extension involved in axis elongation
GO:0046546  development of primary male sexual characteristics
GO:0048546  digestive tract morphogenesis
GO:0009790  embryonic development
GO:0042733  embryonic digit morphogenesis
GO:0008406  gonad development
GO:0071425  hemopoietic stem cell proliferation
GO:0008584  male gonad development
GO:0030514  negative regulation of BMP signaling pathway
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0043154  negative regulation of caspase activity
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0010629  negative regulation of gene expression
GO:0043508  negative regulation of JUN kinase activity
GO:0042662  negative regulation of mesodermal cell fate specification
GO:0050732  negative regulation of peptidyl-tyrosine phosphorylation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001843  neural tube closure
GO:0021915  neural tube development
GO:0003151  outflow tract morphogenesis
GO:0001569  patterning of blood vessels
GO:0090179  planar cell polarity pathway involved in neural tube closure
GO:0045766  positive regulation of angiogenesis
GO:0043065  positive regulation of apoptosis
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0010950  positive regulation of endopeptidase activity
GO:0045600  positive regulation of fat cell differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042981  regulation of apoptosis
GO:0042127  regulation of cell proliferation
GO:0090175  regulation of establishment of planar polarity
GO:0030111  regulation of Wnt receptor signaling pathway
GO:0042493  response to drug
GO:0007584  response to nutrient
GO:0001756  somitogenesis
GO:0001944  vasculature development
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005575  cellular_component
GO:0005737  cytoplasm
GO:0005615  extracellular space
GO:0005886  plasma membrane

Molecular Function

GO:0010577  metalloenzyme activator activity
GO:0003674  molecular_function
GO:0030165  PDZ domain binding
GO:0048018  receptor agonist activity
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding