signal peptide peptidase-like 2B

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:110.60 spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:78 thymus:- bone marrow:- adipose:147.20 bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:113.90 ovary:- testis:- heart:38.80 muscle:- esophagus:- stomach:- intestine:104.70 colon:-     liver/hepato:-        lung:50.70    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001014200
Gene ID 362828
Unigene ID Rn.18529
Probe set ID -
Ensembl ID ENSRNOG00000033794

Orthologous Gene

Human[2]  NM_001077238, NM_152988
Mouse[1]  NM_175195, NM_152988

Chromosomal Region

7q11  [10,354,557  -  10,367,210]

Gene Family (Interpro ID)

IPR000539  Frizzled protein
IPR017981  GPCR, family 2-like
IPR006639  Peptidase A22, presenilin signal peptide
IPR007369  Peptidase A22B, signal peptide peptidase

Link to Pubmed  (Pubmed ID)

12477932
15489334

Gene Ontology  (GO ID)

Biological Process

GO:0006509  membrane protein ectodomain proteolysis
GO:0031293  membrane protein intracellular domain proteolysis
GO:0050776  regulation of immune response

Cellular Component

GO:0010008  endosome membrane
GO:0030660  Golgi-associated vesicle membrane
GO:0071458  integral to cytosolic side of endoplasmic reticulum membrane
GO:0005765  lysosomal membrane
GO:0005886  plasma membrane

Molecular Function

GO:0042500  aspartic endopeptidase activity, intramembrane cleaving
GO:0042803  protein homodimerization activity