signal transducer and activator of transcription 6

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:156 thymus:- bone marrow:- adipose:- bone:117.10 skin:-
GeneChip cerebrum:5.03 cerebellum:5.11 brain stem:5.43 corpus callosum/glia:- pineal gland:- peripheral nerve:5.30 spine:- retina:- eye:5.41 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:4.95 thymus:4.86 bone marrow:5.19 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:227.70 ovary:- testis:- heart:58.20 muscle:- esophagus:- stomach:- intestine:209.30 colon:289.90     liver/hepato:13.30        lung:-    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:4.91 muscle:4.90 esophagus:- stomach:- intestine:4.97 colon:4.66 liver/hepato:- lung:- bladder:- kidney:4.81 pituitary:4.75 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001044250
Gene ID 362896
Unigene ID Rn.6880
Probe set ID AF055292mRNA_at  [RG_U34A]
Ensembl ID ENSRNOG00000025023

Orthologous Gene

Human[2]  NM_001178078, NM_001178079, NM_001178080, NM_001178081, NM_003153
Mouse[2]  NM_009284, NM_001178079, NM_001178080, NM_001178081, NM_003153

Chromosomal Region

7q22  [67,623,534  -  67,642,283]

Gene Family (Interpro ID)

IPR008967  p53-like transcription factor, DNA-binding
IPR013800  STAT transcription factor, all-alpha
IPR015988  STAT transcription factor, coiled coil
IPR013801  STAT transcription factor, DNA-binding

Link to Pubmed  (Pubmed ID)

10486156
11086031
11257135
11912448
12039028
12709397
12874250
12900808
15117875
15365256
15584925
15647835
15687724
16083555
16399078
16648019
16728393
17312100
17705178
17880360
18273035
18362439
19011907
19087723
19531027
21162243
21269961
21985369
22025716
22134058
22504638
22867713
24321062

Gene Ontology  (GO ID)

Biological Process

GO:0070301  cellular response to hydrogen peroxide
GO:0019221  cytokine-mediated signaling pathway
GO:0033598  mammary gland epithelial cell proliferation
GO:0060443  mammary gland morphogenesis
GO:0002829  negative regulation of T-helper 2 type immune response
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0048295  positive regulation of isotype switching to IgE isotypes
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042127  regulation of cell proliferation
GO:0034097  response to cytokine stimulus
GO:0007165  signal transduction
GO:0002296  T-helper 1 cell lineage commitment

Cellular Component

GO:0005737  cytoplasm
GO:0045121  membrane raft
GO:0000790  nuclear chromatin
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0005509  calcium ion binding
GO:0003677  DNA binding
GO:0042802  identical protein binding
GO:0019903  protein phosphatase binding
GO:0043565  sequence-specific DNA binding
GO:0004871  signal transducer activity
GO:0003700  transcription factor activity