interleukin-1 receptor-associated kinase 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:143.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:73.70 spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:156 thymus:122.90 bone marrow:- adipose:- bone:78.10 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:159.30 prostate:113.90 ovary:114.10 testis:- heart:116.30 muscle:- esophagus:- stomach:- intestine:104.70 colon:869.60     liver/hepato:26.60        lung:354.60    bladder:- kidney:63.80 pituitary:533 thyroid/parathyroid:3891.10 adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001127555
Gene ID 363520
Unigene ID Rn.22238
Probe set ID -
Ensembl ID ENSRNOG00000037263

Orthologous Gene

Human[3]  NM_001025242, NM_001025243, NM_001569
Mouse[4]  NM_001177973, NM_001177974, NM_001177975, NM_001177976, NM_008363

Chromosomal Region

Xq37  [159,958,916  -  159,969,045]

Gene Family (Interpro ID)

IPR000488  Death
IPR011029  DEATH-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

12477932
12860565
15793310
15890643
15946255
17668873
18497707
18535784
19717152
20086235
20500689
21235323
21708940
21898345
21925238
22277195
23018031
23324889
23619365
24302991

Gene Ontology  (GO ID)

Biological Process

GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0071456  cellular response to hypoxia
GO:0071222  cellular response to lipopolysaccharide
GO:0019221  cytokine-mediated signaling pathway
GO:0070498  interleukin-1-mediated signaling pathway
GO:0007254  JNK cascade
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0043507  positive regulation of JUN kinase activity
GO:0043406  positive regulation of MAP kinase activity
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0051259  protein oligomerization
GO:0001959  regulation of cytokine-mediated signaling pathway
GO:0070555  response to interleukin-1
GO:0032496  response to lipopolysaccharide
GO:0032494  response to peptidoglycan
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway

Cellular Component

GO:0005811  lipid particle
GO:0016020  membrane

Molecular Function

GO:0005524  ATP binding
GO:0005149  interleukin-1 receptor binding
GO:0016301  kinase activity
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity