DNA (cytosine-5-)-methyltransferase 3 alpha

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:71.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:122.90 bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:38 ovary:114.10 testis:- heart:77.60 muscle:- esophagus:- stomach:- intestine:104.70 colon:-     liver/hepato:-        lung:50.70    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001003957
Gene ID 444984
Unigene ID Rn.92659
Probe set ID -
Ensembl ID ENSRNOG00000026649

Orthologous Gene

Human[4]  NM_022552, NM_153759, NM_175629, NM_175630
Mouse[16]  NM_007872, NM_153743, NM_175629, NM_175630

Chromosomal Region

6q14  [26,802,612  -  26,878,878]

Gene Family (Interpro ID)

IPR011011  Zinc finger, FYVE/PHD-type
IPR013083  Zinc finger, RING/FYVE/PHD-type

Link to Pubmed  (Pubmed ID)

11844796
12138111
12477932
15203217
15616584
18042343
19833194
20729844
21163286
21518035
22342103
24282625

Gene Ontology  (GO ID)

Biological Process

GO:0090116  C-5 methylation of cytosine
GO:0071230  cellular response to amino acid stimulus
GO:0006306  DNA methylation
GO:0043045  DNA methylation during embryonic development
GO:0043046  DNA methylation during gametogenesis
GO:0010424  DNA methylation on cytosine within a CG sequence
GO:0006349  genetic imprinting
GO:0044027  hypermethylation of CpG island
GO:0006346  methylation-dependent chromatin silencing
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0046498  S-adenosylhomocysteine metabolic process
GO:0046499  S-adenosylmethioninamine metabolic process
GO:0007283  spermatogenesis
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0000775  chromosome, centromeric region
GO:0005737  cytoplasm
GO:0000791  euchromatin
GO:0000792  heterochromatin
GO:0005720  nuclear heterochromatin
GO:0016363  nuclear matrix
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0003886  DNA (cytosine-5-)-methyltransferase activity
GO:0051718  DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0003677  DNA binding
GO:0046872  metal ion binding
GO:0045322  unmethylated CpG binding