lysine (K)-specific demethylase 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:95.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:78 thymus:245.80 bone marrow:- adipose:147.20 bone:117.10 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:75.90 ovary:- testis:82.30 heart:77.60 muscle:531.50 esophagus:- stomach:- intestine:- colon:289.90     liver/hepato:39.90        lung:-    bladder:- kidney:255.20 pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:113.80 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001130098
Gene ID 500569
Unigene ID Rn.203461
Probe set ID -
Ensembl ID ENSRNOG00000022372

Orthologous Gene

Human[4]  NM_001009999, NM_015013
Mouse[2]  NM_133872, NM_015013

Chromosomal Region

5q36  [155,299,289  -  155,344,793]

Gene Family (Interpro ID)

IPR006076  FAD dependent oxidoreductase

Link to Pubmed  (Pubmed ID)

20418916
20542065
21124846
22082260
23516587
24111946

Gene Ontology  (GO ID)

Biological Process

GO:0008283  cell proliferation
GO:0030851  granulocyte differentiation
GO:0034720  histone H3-K4 demethylation
GO:0033169  histone H3-K9 demethylation
GO:0001701  in utero embryonic development
GO:0055001  muscle cell development
GO:0043066  negative regulation of apoptosis
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0051572  negative regulation of histone H3-K4 methylation
GO:0051573  negative regulation of histone H3-K9 methylation
GO:0032091  negative regulation of protein binding
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0021983  pituitary gland development
GO:0045648  positive regulation of erythrocyte differentiation
GO:0046886  positive regulation of hormone biosynthetic process
GO:0045654  positive regulation of megakaryocyte differentiation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006482  protein amino acid demethylation
GO:0010725  regulation of primitive erythrocyte differentiation
GO:0006357  regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790  nuclear chromatin
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0050681  androgen receptor binding
GO:0003682  chromatin binding
GO:0032451  demethylase activity
GO:0044212  DNA regulatory region binding
GO:0019899  enzyme binding
GO:0050660  FAD binding
GO:0032452  histone demethylase activity
GO:0034648  histone demethylase activity (H3-dimethyl-K4 specific)
GO:0032453  histone demethylase activity (H3-K4 specific)
GO:0032454  histone demethylase activity (H3-K9 specific)
GO:0030374  ligand-dependent nuclear receptor transcription coactivator activity
GO:0043426  MRF binding
GO:0016491  oxidoreductase activity
GO:0002039  p53 binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding