ryanodine receptor 2, cardiac

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:73.70 spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:116.30 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID XR_008338
Gene ID 689560
Unigene ID Rn.208315
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Mouse [0]  

Chromosomal Region

17q12.1  [69,128,068  -  69,544,742]

Gene Family (Interpro ID)

IPR001870  B302 (SPRY)-like
IPR002048  Calcium-binding EF-hand
IPR018249  EF-HAND 2
IPR018248  EF-Hand domain
IPR016032  Signal transduction response regulator, C-terminal effector
IPR003877  SPla/RYanodine receptor SPRY
IPR018355  SPla/RYanodine receptor subgroup
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

9275181
10444400
11053140
11159936
11590243
11723243
11934703
12401811
12477932
12606683
12829653
15010472
15626694
15731460
15870112
15916736
15980179
16249429
16306226
16483256
16723744
16931553
16971497
17027851
17224993
17234969
17237229
17267548
17313373
17516033
17569730
17627991
17630346
17652368
17693412
17823125
17921453
18718444
18755143
18799678
18979913
19116207
19131648
19284993
20008518
20018773
20177054
20336285
20431056
20445169
20471962
20961976
21156134
21282625
21372126
21421556
21474431
21612318
21649588
21788490
21807619
22067155
22073362
22363773
22404946
22867515
22890710
22962011
23091085
23177664
23233753
23354458
23499836
23943510
24186966
24631538

Gene Ontology  (GO ID)

Biological Process

GO:0030509  BMP signaling pathway
GO:0070588  calcium ion transmembrane transport
GO:0006816  calcium ion transport
GO:0060402  calcium ion transport into cytosol
GO:0019722  calcium-mediated signaling
GO:0060048  cardiac muscle contraction
GO:0003300  cardiac muscle hypertrophy
GO:0006874  cellular calcium ion homeostasis
GO:0071313  cellular response to caffeine
GO:0051480  cytosolic calcium ion homeostasis
GO:0060401  cytosolic calcium ion transport
GO:0005513  detection of calcium ion
GO:0003143  embryonic heart tube morphogenesis
GO:0034220  ion transmembrane transport
GO:0003220  left ventricular cardiac muscle tissue morphogenesis
GO:0071421  manganese ion transmembrane transport
GO:0010460  positive regulation of heart rate
GO:0051284  positive regulation of sequestering of calcium ion
GO:0051481  reduction of cytosolic calcium ion concentration
GO:0055117  regulation of cardiac muscle contraction
GO:0010881  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0002027  regulation of heart rate
GO:0051209  release of sequestered calcium ion into cytosol
GO:0014808  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0031000  response to caffeine
GO:0051592  response to calcium ion
GO:0042493  response to drug
GO:0001666  response to hypoxia
GO:0032026  response to magnesium ion
GO:0007584  response to nutrient
GO:0051775  response to redox state
GO:0070296  sarcoplasmic reticulum calcium ion transport
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0031672  A band
GO:0034704  calcium channel complex
GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0031234  extrinsic to internal side of plasma membrane
GO:0016021  integral to membrane
GO:0005622  intracellular
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0042383  sarcolemma
GO:0030017  sarcomere
GO:0016529  sarcoplasmic reticulum
GO:0033017  sarcoplasmic reticulum membrane
GO:0030018  Z disc

Molecular Function

GO:0005262  calcium channel activity
GO:0005509  calcium ion binding
GO:0048763  calcium-induced calcium release activity
GO:0015278  calcium-release channel activity
GO:0005516  calmodulin binding
GO:0019899  enzyme binding
GO:0042802  identical protein binding
GO:0005218  intracellular ligand-gated calcium channel activity
GO:0005515  protein binding
GO:0034236  protein kinase A catalytic subunit binding
GO:0034237  protein kinase A regulatory subunit binding
GO:0043621  protein self-association
GO:0005219  ryanodine-sensitive calcium-release channel activity
GO:0043924  suramin binding