sclerosteosis

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:- testis:- heart:96.90 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_030584
Gene ID 80722
Unigene ID Rn.95369
Probe set ID -
Ensembl ID ENSRNOG00000020805

Orthologous Gene

Human[1]  NM_025237
Mouse[2]  NM_024449

Chromosomal Region

10q32.1  [91,023,712  -  91,026,759]

Gene Family (Interpro ID)

IPR006207  Cystine knot, C-terminal
IPR008835  Sclerostin

Link to Pubmed  (Pubmed ID)

11179006
15199066
15946907
17549589
17696759
18089564
20641040
21567076
22174402
22766096
23085770
23233270
23337040

Gene Ontology  (GO ID)

Biological Process

GO:0071374  cellular response to parathyroid hormone stimulus
GO:0030514  negative regulation of BMP signaling pathway
GO:0031333  negative regulation of protein complex assembly
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001503  ossification
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0009612  response to mechanical stimulus
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0031012  extracellular matrix
GO:0005615  extracellular space
GO:0005794  Golgi apparatus

Molecular Function

GO:0008201  heparin binding
GO:0005515  protein binding
GO:0008134  transcription factor binding