Rho-associated coiled-coil containing protein kinase 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:107.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:122.90 bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:202.60    bladder:- kidney:- pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_031098
Gene ID 81762
Unigene ID Rn.89756
Probe set ID -
Ensembl ID ENSRNOG00000031092

Orthologous Gene

Human[2]  NM_005406
Mouse[4]  NM_009071

Chromosomal Region

18p13  [1,366,989  -  1,511,865]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000861  HR1-like rho-binding repeat
IPR001849  Pleckstrin homology
IPR017892  Protein kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR015751  Rho-associated coiled-coil containing protein kinase
IPR020684  Rho-associated coiled-coil containing protein kinase-like
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8816443
9353125
11739382
11867620
11872041
11956230
12011049
14517206
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17554619
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18356698
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19106222
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19746421
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21920940
22031832
22215561
22219271
22235829
22566503
22883550
22987919
23258382
23325464
23402758
23899007

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0003383  apical constriction
GO:0006915  apoptosis
GO:0032060  bleb formation
GO:0007010  cytoskeleton organization
GO:0007159  leukocyte adhesion
GO:0050900  leukocyte migration
GO:0050901  leukocyte tethering or rolling
GO:0022614  membrane to membrane docking
GO:0016525  negative regulation of angiogenesis
GO:0043524  negative regulation of neuron apoptosis
GO:0032970  regulation of actin filament-based process
GO:0045616  regulation of keratinocyte differentiation
GO:0007266  Rho protein signal transduction

Cellular Component

GO:0032059  bleb
GO:0005814  centriole
GO:0005856  cytoskeleton
GO:0000139  Golgi membrane
GO:0030027  lamellipodium
GO:0005886  plasma membrane
GO:0001726  ruffle

Molecular Function

GO:0005524  ATP binding
GO:0017049  GTP-Rho binding
GO:0046872  metal ion binding
GO:0005543  phospholipid binding
GO:0004674  protein serine/threonine kinase activity
GO:0017048  Rho GTPase binding