fibroblast growth factor receptor 3

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:191.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:429.50 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:228.20 testis:- heart:38.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:253.30    bladder:- kidney:127.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_053429
Gene ID 84489
Unigene ID Rn.23671
Probe set ID -
Ensembl ID ENSRNOG00000016818

Orthologous Gene

Human[6]  NM_000142, NM_001163213, NM_022965
Mouse[8]  NM_001163215, NM_001163216, NM_001163217, NM_001205270, NM_008010

Chromosomal Region

14q21  [82,683,191  -  82,697,229]

Gene Family (Interpro ID)

IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup
IPR015621  Interleukin-1 receptor
IPR004074  Interleukin-1 receptor, type I/II
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8078586
8875318
10073901
10471491
11020217
11314002
11329138
11444149
11466624
12441294
15231666
15292251
15614790
17467696
17494997
17708356
18072261
18166262
18231634
18413799
20356821
20362703
21691921
21994076
23696738

Gene Ontology  (GO ID)

Biological Process

GO:0060385  axonogenesis involved in innervation
GO:0070977  bone maturation
GO:0060349  bone morphogenesis
GO:0051216  cartilage development
GO:0030154  cell differentiation
GO:0007267  cell-cell signaling
GO:0090102  cochlea development
GO:0048546  digestive tract morphogenesis
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0030900  forebrain development
GO:0048839  inner ear development
GO:0060113  inner ear receptor cell differentiation
GO:0070307  lens fiber cell development
GO:0002089  lens morphogenesis in camera-type eye
GO:0000165  MAPKKK cascade
GO:0002009  morphogenesis of an epithelium
GO:0022010  myelination in the central nervous system
GO:0043066  negative regulation of apoptosis
GO:0048712  negative regulation of astrocyte differentiation
GO:0008285  negative regulation of cell proliferation
GO:0048640  negative regulation of developmental growth
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045839  negative regulation of mitosis
GO:0045879  negative regulation of smoothened signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0014003  oligodendrocyte development
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0045597  positive regulation of cell differentiation
GO:0008284  positive regulation of cell proliferation
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043410  positive regulation of MAPKKK cascade
GO:0090080  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043525  positive regulation of neuron apoptosis
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0010518  positive regulation of phospholipase activity
GO:0031398  positive regulation of protein ubiquitination
GO:0042511  positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777  protein amino acid autophosphorylation
GO:0048678  response to axon injury
GO:0035019  somatic stem cell maintenance
GO:0021762  substantia nigra development

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0009898  internal side of plasma membrane
GO:0005764  lysosome
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0005524  ATP binding
GO:0017134  fibroblast growth factor binding
GO:0005007  fibroblast growth factor receptor activity
GO:0008083  growth factor activity
GO:0004713  protein tyrosine kinase activity