SHC (Src homology 2 domain containing) transforming protein 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:73.70 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:156 thymus:- bone marrow:- adipose:294.40 bone:78.10 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:398.20 prostate:113.90 ovary:228.20 testis:- heart:58.20 muscle:- esophagus:- stomach:- intestine:418.70 colon:-     liver/hepato:26.60        lung:101.30    bladder:- kidney:63.80 pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:170.70 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001164060
Gene ID 85385
Unigene ID Rn.138818
Probe set ID -
Ensembl ID ENSRNOG00000020657

Orthologous Gene

Human[8]  NM_001130040, NM_001130041, NM_001202859, NM_003029, NM_183001
Mouse[8]  NM_001113331, NM_011368, NM_001202859, NM_003029, NM_183001

Chromosomal Region

2q34  [181,616,581  -  181,626,965]

Gene Family (Interpro ID)

IPR006019  Phosphotyrosine interaction (PID/PI)
IPR006020  Phosphotyrosine interaction domain
IPR011993  Pleckstrin homology-type

Link to Pubmed  (Pubmed ID)

1409579
7513704
7798194
8316835
8910399
9271418
9582017
9722539
9748281
9918770
9920808
10612430
11884620
11954667
11970986
12167719
12218049
12477932
12837289
12882334
12933696
13679576
14685170
15044008
15067377
15262993
15375560
15485499
15705774
15837797
15998704
16242150
16246731
16439820
16481327
16699171
16829981
17068140
17274988
17347799
17360381
17363458
17596878
17925406
17986714
18175071
18588882
18957618
19060130
19168439
20392947
22130185
23215692

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0031532  actin cytoskeleton reorganization
GO:0000187  activation of MAPK activity
GO:0007568  aging
GO:0001525  angiogenesis
GO:0016337  cell-cell adhesion
GO:0007507  heart development
GO:0008286  insulin receptor signaling pathway
GO:0000165  MAPKKK cascade
GO:0030182  neuron differentiation
GO:0031175  neuron projection development
GO:0031100  organ regeneration
GO:0045740  positive regulation of DNA replication
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045907  positive regulation of vasoconstriction
GO:0040008  regulation of growth
GO:0051384  response to glucocorticoid stimulus
GO:0042542  response to hydrogen peroxide
GO:0001666  response to hypoxia
GO:0032868  response to insulin stimulus
GO:0035094  response to nicotine
GO:0014070  response to organic cyclic substance
GO:0009636  response to toxin

Cellular Component

GO:0005737  cytoplasm
GO:0010008  endosome membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0070435  Shc-EGFR complex

Molecular Function

GO:0046875  ephrin receptor binding
GO:0005154  epidermal growth factor receptor binding
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005168  neurotrophin TRKA receptor binding
GO:0051219  phosphoprotein binding
GO:0001784  phosphotyrosine binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0030971  receptor tyrosine kinase binding