nuclear receptor subfamily 1, group H, member 3

詳細情報を見る

同義遺伝子名

Nuclear orphan receptor LXR-alpha, LXRA, LXR-a, Liver X receptor alpha, NR1H3, nuclear receptor subfamily 1, group H, member 3, RLD-1, Oxysterols receptor LXR-alpha

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:13 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:5.90 動脈:60 静脈:- リンパ節:- 末梢血:637.70 脾臓:208 胸腺:64.40 骨髄:- 脂肪:363 骨:102.40 皮膚:4.80
GeneChip 大脳:4.75 小脳:4.19 脳幹:4.90 脳梁:4.85 松果体:- 末梢神経:6.39 脊柱:5.06 網膜:- 目:- 動脈:5.75 静脈:4.78 リンパ節:5.88 末梢血:- 脾臓:5.72 胸腺:4.85 骨髄:4.36 脂肪:6.71 骨:- 皮膚:5.62
CAGE 大脳:1.90 小脳:- 脳幹:2.04 脳梁:1.96 松果体:1.94 末梢神経:- 脊柱:1.93 網膜:- 目:- 動脈:2.36 静脈:3.34 リンパ節:3.23 末梢血:- 脾臓:4.05 胸腺:2.12 骨髄:- 脂肪:4.72 骨:- 皮膚:-
RNA-seq 大脳:0.39 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.21 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.41 骨:- 皮膚:-
EST 子宮:27.30 胎盤:29.10 前立腺:67.60 卵巣:37.30 精巣:26 心臓:102.20 骨格筋:60.30 食道:- 胃:- 腸:64.80 結腸:33.90     肝臓:31.70        肺:58.70    膀胱:- 腎臓:83.20 下垂体:- 甲状腺:- 副腎:- 膵臓:8.90 乳腺:9.30 唾液腺:-
GeneChip 子宮:5.07 胎盤:5.84 前立腺:5.37 卵巣:4.98 精巣:6.47 心臓:4.80 骨格筋:4.62 食道:4.39 胃:5.08 腸:5.38 結腸:5.55 肝臓:6.92 肺:5.11 膀胱:- 腎臓:5.68 下垂体:4.58 甲状腺:5.34 副腎:5.44 膵臓:5.05 乳腺:5.89 唾液腺:4.70
CAGE 子宮:2.33 胎盤:3.07 前立腺:2.77 卵巣:2.33 精巣:2.97 心臓:2.35 骨格筋:1.54 食道:2.30 胃:- 腸:2.99 結腸:3.11     肝臓:3.50    肺:2.85 膀胱:2.39 腎臓:2.19 下垂体:1.17 甲状腺:2.50 副腎:- 膵臓:2.18 乳腺:3.56 唾液腺:2.12
RNA-seq 子宮:- 胎盤:- 前立腺:0.18 卵巣:0.65 精巣:0.32 心臓:0.44 骨格筋:0.18 食道:- 胃:- 腸:- 結腸:0.31     肝臓:0.10        肺:0.29    膀胱:- 腎臓:0.59 下垂体:- 甲状腺:1.14 副腎:1.76 膵臓:- 乳腺:0.87 唾液腺:-

IDs

Refseq ID NM_001130101
Gene ID 10062
Unigene ID Hs.438863
Probe set ID 203920_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000025434
GTEx ID ENSG00000025434

オーソログ対応遺伝子

マウス[1]  NM_001177730, NM_013839
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

7744246
8510758
8621574
9013544
9231657
9630215
10022764
11035776
11090131
11135616
11149950
11875109
12032151
12040021
12054659
12117567
12161442
12198243
12470296
12477932
12663743
12724417
12932788
12957674
14699103
14702039
15319359
15342556
15353176
15489334
15489335
15539633
15548517
15604093
15615782
15625283
16054077
16106051
16141411
16143103
16170053
16249184
16341674
16344560
16354658
16482468
16567856
16758300
16904112
16920108
16941683
16956579
16973760
17108812
17110595
17135302
17186944
17217555
17218271
17255360
17272748
17296605
17391100
17396233
17405904
17416342
17452725
17628006
17644777
17693624
17724434
17766241
17845217
17936707
17960176
18007013
18024509
18096827
18182682
18209740
18250151
18276933
18327405
18372238
18511497
18562803
18636124
18660489
18669643
18789440
18854425
19060910
19105208
19119143
19164445
19201410
19211025
19229075
19261092
19292929
19360318
19366697
19380774
19426978
19436111
19481530
19628791
19645823
19697157
19796621
19798078
19837721
19913121
19933273
20005944
20037595
20057170
20080977
20118482
20139031
20190811
20211142
20219900
20237496
20364260
20410489
20494359
20506155
20628086
20655109
20686565
20836841
20837115
20855565
20868688
20945144
21042792
21125317
21136146
21187453
21245992
21266776
21310851
21315073
21316679
21349840
21350215
21356276
21440016
21562465
21625070
21775116
21832049
21889884
21903943
21937108
21951066
21988832
22027013
22137263
22257474
22311022
22367754
22399489
22399527
22457708
22503545
22547570
22569763
22610535
22623531
22634718
22641099
22707265
22723445
22749359
22766509
22916038
22939624
22969086
22984430
22990668
23018104
23041609
23099324
23163651
23185273
23313547
23393188
23416078
23451202
23455924
23496987
23564066
23680128
23686114
23732298
23733886
23838803
23867395
24009820
24036496
24100084
24118845
24265317
24289152

遺伝子オントロジー  (GO ID)

Biological Process

GO:0043277  apoptotic cell clearance
GO:0044255  cellular lipid metabolic process
GO:0071222  cellular response to lipopolysaccharide
GO:0042632  cholesterol homeostasis
GO:0010467  gene expression
GO:0055088  lipid homeostasis
GO:0010887  negative regulation of cholesterol storage
GO:0050728  negative regulation of inflammatory response
GO:0060336  negative regulation of interferon-gamma-mediated signaling pathway
GO:0032369  negative regulation of lipid transport
GO:0043031  negative regulation of macrophage activation
GO:0010745  negative regulation of macrophage derived foam cell differentiation
GO:0090188  negative regulation of pancreatic juice secretion
GO:0048550  negative regulation of pinocytosis
GO:0045861  negative regulation of proteolysis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0032270  positive regulation of cellular protein metabolic process
GO:0010875  positive regulation of cholesterol efflux
GO:0032376  positive regulation of cholesterol transport
GO:0045723  positive regulation of fatty acid biosynthetic process
GO:0051006  positive regulation of lipoprotein lipase activity
GO:0010870  positive regulation of receptor biosynthetic process
GO:0034145  positive regulation of toll-like receptor 4 signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0010867  positive regulation of triglyceride biosynthetic process
GO:0042752  regulation of circadian rhythm
GO:0032570  response to progesterone stimulus
GO:0055092  sterol homeostasis
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0070328  triglyceride homeostasis

Cellular Component

GO:0000790  nuclear chromatin
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0015485  cholesterol binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0004879  ligand-dependent nuclear receptor activity
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003707  steroid hormone receptor activity
GO:0032810  sterol response element binding
GO:0003713  transcription coactivator activity
GO:0008270  zinc ion binding