toll-interleukin 1 receptor (TIR) domain containing adaptor protein

詳細情報を見る

同義遺伝子名

MyD88 adapter-like protein, Adaptor protein Wyatt, FLJ42305, TIRAP, TIR domain-containing adapter protein, wyatt, Mal

正常組織・臓器 40分類
細胞株・初代培養細胞・成体組織・胎児組織 (FANTOM5 CAGE)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:8.30

小脳:25.20

脳幹:-

脳梁:29.20

松果体:-

末梢神経:30.70

脊柱:-

網膜:118.60

目:17.60

動脈:-

静脈:-

リンパ節:30.30

末梢血:18.20

脾臓:-

胸腺:12.90

骨髄:19.70

脂肪:-

骨:-

皮膚:33.60

GeneChip

nodata

CAGE

大脳:1.87

小脳:-

脳幹:1.66

脳梁:1.87

松果体:2.45

末梢神経:-

脊柱:1.98

網膜:-

目:-

動脈:2.81

静脈:2.60

リンパ節:2.77

末梢血:-

脾臓:2.79

胸腺:1.52

骨髄:-

脂肪:2.42

骨:-

皮膚:-

RNA-seq

大脳:0.96

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:1.86

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:1.99

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:18.20

胎盤:14.60

前立腺:33.80

卵巣:74.50

精巣:-

心臓:12.80

骨格筋:20.10

食道:-

胃:1741.90

腸:-

結腸:-

肝臓:-

肺:34.20

膀胱:-

腎臓:20.80

下垂体:-

甲状腺:163.70

副腎:-

膵臓:26.70

乳腺:9.30

唾液腺:-

GeneChip

nodata

CAGE

子宮:2.73

胎盤:2.40

前立腺:2.68

卵巣:2.65

精巣:1.69

心臓:2.46

骨格筋:2.31

食道:2.51

胃:-

腸:3.04

結腸:3.11

肝臓:2.76

肺:2.82

膀胱:2.69

腎臓:2.45

下垂体:2.57

甲状腺:2.25

副腎:-

膵臓:2.98

乳腺:3.09

唾液腺:3.05

RNA-seq

子宮:-

胎盤:-

前立腺:2.44

卵巣:2.60

精巣:1.64

心臓:1.32

骨格筋:1.47

食道:-

胃:-

腸:-

結腸:1.51

肝臓:1.79

肺:1.13

膀胱:-

腎臓:1.61

下垂体:-

甲状腺:1.81

副腎:2.14

膵臓:-

乳腺:1.79

唾液腺:-

IDs

Refseq ID	NM_001039661
Gene ID	114609
Unigene ID	Hs.537126
Probe set ID	-
Ensembl ID	ENSG00000150455
GTEx ID	ENSG00000150455

オーソログ対応遺伝子

マウス[1]	NM_001177845, NM_001177846, NM_001177847, NM_054096
ラット[1]	NM_001177845, NM_001177846, NM_001177847, NM_054096

染色体

11q24.2 [126,152,960 - 126,168,740]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR000157

Toll-Interleukin receptor

遺伝子オントロジー (GO ID)

Biological Process

GO:0070935	3'-UTR-mediated mRNA stabilization
GO:0007166	cell surface receptor linked signal transduction
GO:0071221	cellular response to bacterial lipopeptide
GO:0071223	cellular response to lipoteichoic acid
GO:0050830	defense response to Gram-positive bacterium
GO:0007249	I-kappaB kinase/NF-kappaB cascade
GO:0006954	inflammatory response
GO:0045087	innate immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0030099	myeloid cell differentiation
GO:0044130	negative regulation of growth of symbiont in host
GO:0030890	positive regulation of B cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032735	positive regulation of interleukin-12 production
GO:0032738	positive regulation of interleukin-15 production
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0032757	positive regulation of interleukin-8 production
GO:0046330	positive regulation of JNK cascade
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0090073	positive regulation of protein homodimerization activity
GO:0034137	positive regulation of toll-like receptor 2 signaling pathway
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0032760	positive regulation of tumor necrosis factor production
GO:0045088	regulation of innate immune response
GO:0032648	regulation of interferon-beta production
GO:0032496	response to lipopolysaccharide
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0002224	toll-like receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030139	endocytic vesicle
GO:0005886	plasma membrane
GO:0032587	ruffle membrane

Molecular Function

GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0046982	protein heterodimerization activity
GO:0042803	protein homodimerization activity
GO:0005080	protein kinase C binding