dopamine receptor D2

 詳細情報を見る

同義遺伝子名

dopamine receptor D2, DRD2, Dopamine D2 receptor, D2R, D2DR, D(2) dopamine receptor

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:3.60 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:61.30 脊柱:112.30 網膜:- 目:17.60 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:6.06 小脳:6.14 脳幹:6.35 脳梁:5.96 松果体:- 末梢神経:5.78 脊柱:5.79 網膜:- 目:- 動脈:5.88 静脈:6.01 リンパ節:5.76 末梢血:- 脾臓:5.58 胸腺:5.61 骨髄:5.74 脂肪:5.70 骨:- 皮膚:5.77
CAGE 大脳:1.36 小脳:- 脳幹:0.39 脳梁:1.38 松果体:0.51 末梢神経:- 脊柱:0.29 網膜:- 目:- 動脈:1.03 静脈:0.34 リンパ節:0.03 末梢血:- 脾臓:0 胸腺:0 骨髄:- 脂肪:0 骨:- 皮膚:-
RNA-seq 大脳:0.06 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.00 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.00 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:- 前立腺:22.50 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:116 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:5.75 胎盤:5.88 前立腺:5.50 卵巣:5.77 精巣:5.67 心臓:5.87 骨格筋:5.90 食道:5.80 胃:5.70 腸:5.78 結腸:5.96 肝臓:5.97 肺:5.74 膀胱:- 腎臓:5.93 下垂体:6.35 甲状腺:5.62 副腎:5.93 膵臓:6.18 乳腺:5.69 唾液腺:6.25
CAGE 子宮:1.05 胎盤:0 前立腺:0.49 卵巣:0 精巣:0.69 心臓:0.30 骨格筋:0 食道:0.26 胃:- 腸:0.07 結腸:0.12     肝臓:0    肺:0.10 膀胱:0 腎臓:0 下垂体:4.50 甲状腺:0 副腎:- 膵臓:0 乳腺:0 唾液腺:1.39
RNA-seq 子宮:- 胎盤:- 前立腺:0.06 卵巣:0.07 精巣:0.47 心臓:0 骨格筋:0 食道:- 胃:- 腸:- 結腸:0.00     肝臓:0        肺:0.00    膀胱:- 腎臓:0 下垂体:- 甲状腺:0.00 副腎:0.00 膵臓:- 乳腺:0.12 唾液腺:-

詳細情報

IDs

Refseq ID NM_000795
Gene ID 1813
Unigene ID Hs.73893
Probe set ID 216924_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000149295
GTEx ID ENSG00000149295

オーソログ対応遺伝子

マウス[1]  NM_010077
ラット [0]  

染色体

11q23.2  [113,280,318  -  113,346,413]

遺伝子ファミリー (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR001922  Dopamine D2 receptor
IPR000929  Dopamine receptor
IPR017452  GPCR, rhodopsin-like superfamily

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0060158  activation of phospholipase C activity by dopamine receptor signaling pathway
GO:0032147  activation of protein kinase activity
GO:0021984  adenohypophysis development
GO:0007628  adult walking behavior
GO:0050482  arachidonic acid secretion
GO:0008306  associative learning
GO:0031223  auditory behavior
GO:0007409  axonogenesis
GO:0048148  behavioral response to cocaine
GO:0048149  behavioral response to ethanol
GO:0048755  branching morphogenesis of a nerve
GO:0006874  cellular calcium ion homeostasis
GO:0021853  cerebral cortex GABAergic interneuron migration
GO:0032922  circadian regulation of gene expression
GO:0042417  dopamine metabolic process
GO:0051482  elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
GO:0007631  feeding behavior
GO:0002031  G-protein coupled receptor internalization
GO:0007625  grooming behavior
GO:0007195  inhibition of adenylate cyclase activity by dopamine receptor signaling pathway
GO:0007626  locomotory behavior
GO:0007616  long-term memory
GO:0007194  negative regulation of adenylate cyclase activity
GO:0045776  negative regulation of blood pressure
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0042321  negative regulation of circadian sleep/wake cycle, sleep
GO:0060160  negative regulation of dopamine receptor signaling pathway
GO:0046676  negative regulation of insulin secretion
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0050709  negative regulation of protein secretion
GO:0051967  negative regulation of synaptic transmission, glutamatergic
GO:0007270  nerve-nerve synaptic transmission
GO:0001976  neurological system process involved in regulation of systemic arterial blood pressure
GO:0030432  peristalsis
GO:0046488  phosphatidylinositol metabolic process
GO:0043473  pigmentation
GO:0051586  positive regulation of dopamine uptake
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0045745  positive regulation of G-protein coupled receptor protein signaling pathway
GO:0060124  positive regulation of growth hormone secretion
GO:0040018  positive regulation of multicellular organism growth
GO:0002052  positive regulation of neuroblast proliferation
GO:0002092  positive regulation of receptor internalization
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0060134  prepulse inhibition
GO:0007243  protein kinase cascade
GO:0008104  protein localization
GO:0051481  reduction of cytosolic calcium ion concentration
GO:0030814  regulation of cAMP metabolic process
GO:0014059  regulation of dopamine secretion
GO:0051584  regulation of dopamine uptake
GO:0002027  regulation of heart rate
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0043666  regulation of phosphoprotein phosphatase activity
GO:0043266  regulation of potassium ion transport
GO:0002028  regulation of sodium ion transport
GO:0032228  regulation of synaptic transmission, GABAergic
GO:0051209  release of sequestered calcium ion into cytosol
GO:0001975  response to amphetamine
GO:0048678  response to axon injury
GO:0042220  response to cocaine
GO:0042493  response to drug
GO:0034776  response to histamine
GO:0001666  response to hypoxia
GO:0014854  response to inactivity
GO:0010039  response to iron ion
GO:0009416  response to light stimulus
GO:0043278  response to morphine
GO:0035094  response to nicotine
GO:0009636  response to toxin
GO:0007608  sensory perception of smell
GO:0007416  synapse assembly
GO:0001963  synaptic transmission, dopaminergic
GO:0001659  temperature homeostasis
GO:0008542  visual learning
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0001669  acrosomal vesicle
GO:0030424  axon
GO:0030425  dendrite
GO:0043197  dendritic spine
GO:0030139  endocytic vesicle
GO:0005887  integral to plasma membrane
GO:0016328  lateral plasma membrane
GO:0043679  nerve terminal
GO:0043204  perikaryon
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0030672  synaptic vesicle membrane

Molecular Function

GO:0004935  adrenoceptor activity
GO:0035240  dopamine binding
GO:0001591  dopamine receptor activity, coupled via Gi/Go
GO:0008144  drug binding
GO:0035255  ionotropic glutamate receptor binding
GO:0015459  potassium channel regulator activity
GO:0005515  protein binding