epidermal growth factor (beta-urogastrone)

 詳細情報を見る

同義遺伝子名

Pro-epidermal growth factor precursor, URG, epidermal growth factor (beta-urogastrone), EGF

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:5.90 小脳:- 脳幹:- 脳梁:87.50 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:11.80 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:40.30 骨:- 皮膚:4.80
GeneChip 大脳:3.34 小脳:3.30 脳幹:3.40 脳梁:3.45 松果体:- 末梢神経:3.30 脊柱:3.53 網膜:- 目:- 動脈:3.28 静脈:3.43 リンパ節:3.18 末梢血:- 脾臓:3.02 胸腺:3.25 骨髄:3.38 脂肪:3.18 骨:- 皮膚:3.58
CAGE 大脳:0.33 小脳:- 脳幹:0.61 脳梁:0.34 松果体:0.26 末梢神経:- 脊柱:0.48 網膜:- 目:- 動脈:0.34 静脈:0.34 リンパ節:0.19 末梢血:- 脾臓:0.17 胸腺:0 骨髄:- 脂肪:0.46 骨:- 皮膚:-
RNA-seq 大脳:0.00 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.00 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:3.60 前立腺:11.30 卵巣:- 精巣:- 心臓:- 骨格筋:60.30 食道:- 胃:- 腸:- 結腸:17     肝臓:10.60        肺:19.60    膀胱:125.60 腎臓:259.90 下垂体:116 甲状腺:- 副腎:- 膵臓:35.60 乳腺:- 唾液腺:-
GeneChip 子宮:3.31 胎盤:3.05 前立腺:4.21 卵巣:3.17 精巣:3.22 心臓:3.89 骨格筋:6.46 食道:4.04 胃:3.20 腸:4.32 結腸:3.21 肝臓:3.29 肺:3.24 膀胱:- 腎臓:9.02 下垂体:3.26 甲状腺:3.51 副腎:3.14 膵臓:5.05 乳腺:4.17 唾液腺:5.60
CAGE 子宮:0.27 胎盤:0 前立腺:0.33 卵巣:0 精巣:0.13 心臓:0.77 骨格筋:2.30 食道:0.63 胃:- 腸:0 結腸:0     肝臓:0    肺:0.52 膀胱:0.33 腎臓:2.74 下垂体:0.10 甲状腺:0.57 副腎:- 膵臓:3.59 乳腺:0.55 唾液腺:0.83
RNA-seq 子宮:- 胎盤:- 前立腺:0.65 卵巣:0.00 精巣:0.00 心臓:0.46 骨格筋:2.96 食道:- 胃:- 腸:- 結腸:0.00     肝臓:0        肺:0.00    膀胱:- 腎臓:3.88 下垂体:- 甲状腺:2.55 副腎:0.00 膵臓:- 乳腺:0.73 唾液腺:-

詳細情報

IDs

Refseq ID NM_001963
Gene ID 1950
Unigene ID Hs.419815
Probe set ID 206254_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000138798
GTEx ID ENSG00000138798

オーソログ対応遺伝子

マウス[1]  NM_010113
ラット [0]  

染色体

4q25  [110,834,040  -  110,933,422]

遺伝子ファミリー (Interpro ID)

IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

300079
1281549
1334406
1501243
1522591
1639032
2789514
2790960
3486749
3491360
6290982
6382023
6603475
7540053
7558411
7615511
7640657
7730382
7736574
8077234
8123596
8413296
8419140
8639530
8796265
8845374
9188692
9356464
9482941
9544989
9661876
9687510
9712850
9925763
10085134
10199559
10436156
10559227
10567358
10579352
10648629
10734310
10748174
10788520
10913131
10973965
11438527
11751923
11786904
11796824
11823423
11844511
11894095
11896055
11903419
11914075
11925427
11950840
11971908
11994282
12009575
12093292
12138086
12141529
12163055
12163506
12192610
12202942
12218189
12297050
12368284
12388817
12397374
12425525
12477932
12508124
12531699
12540376
12593796
12620237
12637502
12643788
12667326
12672817
12722480
12768436
12788694
12795334
12879019
12954631
12960147
14507446
14520709
14523024
14560030
14614718
14651960
14662770
14665621
14676838
15003992
15063762
15081423
15087376
15129177
15175028
15180992
15183666
15192046
15194442
15252009
15256384
15260478
15272014
15329330
15373781
15373782
15373802
15475003
15481560
15485655
15485674
15488707
15489334
15491342
15509542
15536154
15574420
15611079
15613483
15620700
15622242
15659382
15663953
15675968
15729146
15735691
15748906
15798095
15802268
15837620
15860930
15886816
15901830
15913871
15950078
15950906
15962011
15982634
16019439
16033767
16115648
16134968
16210470
16214932
16248985
16274239
16274250
16282324
16314496
16316319
16332692
16344560
16407418
16407834
16413767
16428382
16436184
16502470
16584205
16636672
16691190
16728406
16762922
16788380
16820871
16837648
16847055
16872636
16885506
16939220
16946702
16969495
16979250
17123472
17175377
17204151
17223314
17227756
17311928
17316357
17324121
17334773
17392355
17397984
17433039
17453000
17473192
17479438
17545148
17562024
17567965
17573555
17578349
17612563
17617058
17626784
17634901
17661145
17673689
17762162
17851837
17852426
17897319
17898861
17912028
17940864
17943082
17950068
17962208
17968796
17986122
17991726
17991733
18006148
18036246
18080773
18088275
18094008
18096367
18156174
18167406
18187620
18212060
18271526
18271972
18276761
18292095
18325497
18349392
18365874
18382118
18398039
18434322
18441095
18463167
18467441
18483390
18485152
18487214
18490463
18511414
18519765
18543351
18571008
18583979
18632979
18676680
18722874
18757521
18773861
18813355
18831963
18844210
18990689
19010984
19011936
19014905
19020743
19032382
19056867
19064572
19073827
19074885
19081071
19086053
19087984
19110611
19124506
19127217
19141999
19144868
19167371
19170196
19172394
19179548
19203995
19236842
19319135
19336395
19380191
19388850
19403524
19415484
19453261
19460345
19470771
19484147
19488063
19491269
19492417
19520791
19531499
19544388
19549686
19549816
19592671
19604397
19608641
19619867
19624835
19625176
19634110
19670348
19692168
19708171
19727227
19749156
19817957
19823871
19834535
19840254
19840943
19853299
19880507
19887603
19895983
19896111
19900104
19913121
19920151
19921131
19951549
19953086
19996314
20033794
20036812
20092031
20101173
20108217
20126978
20127414
20157331
20158379
20164030
20169434
20197289
20201065
20201926
20203692
20207214
20303009
20332099
20351270
20362419
20364107
20375273
20379614
20398806
20412119
20418097
20423485
20424473
20429940
20430735
20444693
20453000
20466569
20472833
20482449
20487573
20498653
20514023
20564212
20587610
20598233
20606012
20621058
20628086
20628624
20631636
20634891
20644561
20674545
20690902
20714325
20727496
20727996
20800603
20818748
20819124
20830310
20832399
20851879
20854793
20889718
20963824
20969541
21029725
21048224
21062739
21087604
21099256
21123997
21186997
21187523
21209099
21212517
21224998
21236296
21247755
21273531
21274378
21309478
21358296
21376205
21436680
21439278
21533003
21567271
21678081
21752154
21868386
21872446
21971700
21982438
22022452
22033246
22070650
22087246
22106858
22122913
22129558
22236006
22279551
22293333
22308022
22401280
22403631
22404757
22413835
22416276
22433566
22457050
22479527
22479638
22481252
22493503
22503865
22504456
22505024
22532606
22534548
22574813
22578596
22621366
22668508
22677173
22701712
22721997
22727668
22745586
22773267
22782629
22797360
22829589
22829952
22852842
22914212
22925500
22951723
22990108
23007402
23090954
23188118
23201894
23219876
23228281
23229345
23382691
23403233
23419149
23457387
23466131
23542467
23577098
23608378
23631828
23645212
23689072
23711349
23731208
23790025
23810060
23843455
23844832
23869217
23869762
23872928
23899513
23902938
23912699
23936413
23963773
23986482
24036907
24039773
24043306
24045955
24160245
24268047
24346284

遺伝子オントロジー  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0007171  activation of transmembrane receptor protein tyrosine kinase activity
GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0048754  branching morphogenesis of a tube
GO:0006260  DNA replication
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0070371  ERK1 and ERK2 cascade
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0045087  innate immune response
GO:0060749  mammary gland alveolus development
GO:0042059  negative regulation of epidermal growth factor receptor signaling pathway
GO:0051048  negative regulation of secretion
GO:0048011  nerve growth factor receptor signaling pathway
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0048015  phosphoinositide-mediated signaling
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0045741  positive regulation of epidermal growth factor receptor activity
GO:0021940  positive regulation of granule cell precursor proliferation
GO:0043406  positive regulation of MAP kinase activity
GO:0045840  positive regulation of mitosis
GO:0010800  positive regulation of peptidyl-threonine phosphorylation
GO:0042327  positive regulation of phosphorylation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0007165  signal transduction
GO:0007262  STAT protein nuclear translocation

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016021  integral to membrane
GO:0005886  plasma membrane
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0005509  calcium ion binding
GO:0005154  epidermal growth factor receptor binding
GO:0008083  growth factor activity
GO:0005515  protein binding
GO:0030297  transmembrane receptor protein tyrosine kinase activator activity