lysine (K)-specific demethylase 1A

詳細情報を見る

同義遺伝子名

LSD1, BRAF35-HDAC complex protein BHC110, BHC110, KIAA0601, amine oxidase (flavin containing) domain 2, Lysine-specific histone demethylase 1, AOF2

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:56.90 小脳:25.20 脳幹:- 脳梁:- 松果体:296.70 末梢神経:30.70 脊柱:- 網膜:- 目:94 動脈:- 静脈:- リンパ節:30.30 末梢血:18.20 脾臓:- 胸腺:38.70 骨髄:39.40 脂肪:- 骨:51.20 皮膚:187.20
GeneChip 大脳:7.29 小脳:7.52 脳幹:7.34 脳梁:7.02 松果体:- 末梢神経:7.13 脊柱:7 網膜:- 目:- 動脈:7.11 静脈:7.03 リンパ節:7.07 末梢血:- 脾臓:6.87 胸腺:7.92 骨髄:7.19 脂肪:7.23 骨:- 皮膚:7.39
CAGE 大脳:3.78 小脳:- 脳幹:3.52 脳梁:3.53 松果体:3.67 末梢神経:- 脊柱:3.18 網膜:- 目:- 動脈:3.56 静脈:3.79 リンパ節:3.40 末梢血:- 脾臓:3.42 胸腺:4.48 骨髄:- 脂肪:3.56 骨:- 皮膚:-
RNA-seq 大脳:3.32 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.63 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:3.52 骨:- 皮膚:-
EST 子宮:54.70 胎盤:25.50 前立腺:- 卵巣:74.50 精巣:225 心臓:76.60 骨格筋:- 食道:- 胃:63.70 腸:32.40 結腸:50.90     肝臓:10.60        肺:48.90    膀胱:- 腎臓:20.80 下垂体:- 甲状腺:- 副腎:- 膵臓:8.90 乳腺:288.10 唾液腺:-
GeneChip 子宮:7.65 胎盤:7.22 前立腺:7.63 卵巣:7.95 精巣:9.18 心臓:7.19 骨格筋:7.72 食道:7.42 胃:7.16 腸:7.43 結腸:7.46 肝臓:6.77 肺:7.18 膀胱:- 腎臓:7.19 下垂体:7.80 甲状腺:7.32 副腎:7.32 膵臓:7.27 乳腺:7.48 唾液腺:7.31
CAGE 子宮:4.06 胎盤:3.46 前立腺:3.81 卵巣:3.91 精巣:5.07 心臓:3.64 骨格筋:3.92 食道:3.64 胃:- 腸:3.49 結腸:3.79     肝臓:3.34    肺:3.36 膀胱:3.72 腎臓:3.46 下垂体:4.18 甲状腺:3.77 副腎:- 膵臓:3.61 乳腺:3.22 唾液腺:3.74
RNA-seq 子宮:- 胎盤:- 前立腺:4.00 卵巣:4.54 精巣:5.86 心臓:2.80 骨格筋:4.17 食道:- 胃:- 腸:- 結腸:3.93     肝臓:2.89        肺:3.47    膀胱:- 腎臓:3.60 下垂体:- 甲状腺:3.92 副腎:3.33 膵臓:- 乳腺:3.44 唾液腺:-

IDs

Refseq ID NM_015013
Gene ID 23028
Unigene ID Hs.591518
Probe set ID 212348_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000004487
GTEx ID ENSG00000004487

オーソログ対応遺伝子

マウス[2]  NM_133872
ラット[1]  NM_001130098

染色体

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

遺伝子オントロジー  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0008283  cell proliferation
GO:0030851  granulocyte differentiation
GO:0034720  histone H3-K4 demethylation
GO:0033169  histone H3-K9 demethylation
GO:0001701  in utero embryonic development
GO:0055001  muscle cell development
GO:0043392  negative regulation of DNA binding
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0051572  negative regulation of histone H3-K4 methylation
GO:0051573  negative regulation of histone H3-K9 methylation
GO:0032091  negative regulation of protein binding
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0021983  pituitary gland development
GO:0045648  positive regulation of erythrocyte differentiation
GO:0046886  positive regulation of hormone biosynthetic process
GO:0045654  positive regulation of megakaryocyte differentiation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006482  protein amino acid demethylation
GO:0010725  regulation of primitive erythrocyte differentiation
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0000790  nuclear chromatin
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0050681  androgen receptor binding
GO:0003682  chromatin binding
GO:0032451  demethylase activity
GO:0044212  DNA regulatory region binding
GO:0019899  enzyme binding
GO:0050660  FAD binding
GO:0032452  histone demethylase activity
GO:0034648  histone demethylase activity (H3-dimethyl-K4 specific)
GO:0032453  histone demethylase activity (H3-K4 specific)
GO:0032454  histone demethylase activity (H3-K9 specific)
GO:0030374  ligand-dependent nuclear receptor transcription coactivator activity
GO:0043426  MRF binding
GO:0016491  oxidoreductase activity
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding