fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

 詳細情報を見る

同義遺伝子名

Vascular permeability factor receptor, VEGFR1, Fms-like tyrosine kinase 1, FRT, FLT, Flt-1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, VEGFR-1, FLT1

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST nodata
GeneChip 大脳:6.52 小脳:5.81 脳幹:6.66 脳梁:6.32 松果体:- 末梢神経:6.06 脊柱:6.15 網膜:- 目:- 動脈:6.76 静脈:6.67 リンパ節:6.22 末梢血:- 脾臓:6.99 胸腺:5.01 骨髄:5.83 脂肪:6.76 骨:- 皮膚:5.99
CAGE 大脳:3.62 小脳:- 脳幹:3.95 脳梁:3.28 松果体:3.18 末梢神経:- 脊柱:3.86 網膜:- 目:- 動脈:3.32 静脈:3.12 リンパ節:2.48 末梢血:- 脾臓:3.66 胸腺:1.36 骨髄:- 脂肪:4.83 骨:- 皮膚:-
RNA-seq 大脳:3.65 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.99 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:5.32 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST nodata
GeneChip 子宮:6.50 胎盤:8.08 前立腺:6.37 卵巣:5.94 精巣:5.59 心臓:8.13 骨格筋:7 食道:5.90 胃:6.87 腸:6.66 結腸:6.56 肝臓:6.62 肺:7.21 膀胱:- 腎臓:7.19 下垂体:5.75 甲状腺:7.83 副腎:7.32 膵臓:6.06 乳腺:6.35 唾液腺:6.28
CAGE 子宮:3.72 胎盤:6.74 前立腺:3.39 卵巣:3.60 精巣:2.27 心臓:4.53 骨格筋:4.27 食道:3.27 胃:- 腸:2.56 結腸:3.02     肝臓:3.67    肺:4.37 膀胱:3.94 腎臓:3.84 下垂体:2.75 甲状腺:4.26 副腎:- 膵臓:2.60 乳腺:4.49 唾液腺:2.06
RNA-seq 子宮:- 胎盤:- 前立腺:3.00 卵巣:2.22 精巣:2.37 心臓:3.27 骨格筋:3.19 食道:- 胃:- 腸:- 結腸:5.76     肝臓:2.21        肺:5.57    膀胱:- 腎臓:2.90 下垂体:- 甲状腺:3.70 副腎:2.97 膵臓:- 乳腺:2.58 唾液腺:-

詳細情報

IDs

Refseq ID NM_001159920
Gene ID 2321
Unigene ID -
Probe set ID 222033_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000102755
GTEx ID ENSG00000102755

オーソログ対応遺伝子

マウス[2]  NM_010228
ラット [0]  

染色体

13q12.3  [28,874,489  -  29,069,265]

遺伝子ファミリー (Interpro ID)

IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain
IPR009134  Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
IPR009135  Tyrosine-protein kinase, vascular endothelial growth factor receptor 1 (VEGFR1), N-terminal

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0048514  blood vessel morphogenesis
GO:0030154  cell differentiation
GO:0016477  cell migration
GO:0048598  embryonic morphogenesis
GO:0002548  monocyte chemotaxis
GO:0001569  patterning of blood vessels
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0043406  positive regulation of MAP kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0010863  positive regulation of phospholipase C activity
GO:0030949  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0046777  protein amino acid autophosphorylation
GO:0002040  sprouting angiogenesis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005768  endosome
GO:0005615  extracellular space
GO:0005794  Golgi apparatus
GO:0005887  integral to plasma membrane
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0005021  vascular endothelial growth factor receptor activity