fms-related tyrosine kinase 3

詳細情報を見る

同義遺伝子名

STK-1, CD135 antigen, FL cytokine receptor precursor, Tyrosine-protein kinase receptor FLT3, fms-related tyrosine kinase 3, Stem cell tyrosine kinase 1, CD135, FLK2, FLT3, STK1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:1.20 小脳:63 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:11.80 動脈:- 静脈:- リンパ節:10.10 末梢血:18.20 脾臓:- 胸腺:38.70 骨髄:137.80 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:4.43 小脳:5.30 脳幹:4.63 脳梁:4.06 松果体:- 末梢神経:4.37 脊柱:4.48 網膜:- 目:- 動脈:4.28 静脈:4.39 リンパ節:4.48 末梢血:- 脾臓:4.21 胸腺:4.40 骨髄:4.66 脂肪:4.43 骨:- 皮膚:4.26
CAGE 大脳:1.04 小脳:- 脳幹:1.11 脳梁:0.39 松果体:0 末梢神経:- 脊柱:1.25 網膜:- 目:- 動脈:0.87 静脈:2.13 リンパ節:2.17 末梢血:- 脾臓:1.99 胸腺:2.05 骨髄:- 脂肪:0.26 骨:- 皮膚:-
RNA-seq 大脳:0.43 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.93 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.13 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:11.30 卵巣:- 精巣:17.30 心臓:- 骨格筋:- 食道:- 胃:- 腸:32.40 結腸:-     肝臓:-        肺:4.90    膀胱:125.60 腎臓:31.20 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:3.97 胎盤:4.10 前立腺:3.82 卵巣:4.04 精巣:4.27 心臓:4.40 骨格筋:4.58 食道:4.09 胃:4.19 腸:4.41 結腸:4.48 肝臓:4.19 肺:4.15 膀胱:- 腎臓:4.44 下垂体:4.15 甲状腺:4.01 副腎:3.99 膵臓:4.95 乳腺:4.11 唾液腺:4.30
CAGE 子宮:0.42 胎盤:0 前立腺:0.15 卵巣:0.20 精巣:0.82 心臓:0.52 骨格筋:0.17 食道:0.40 胃:- 腸:1.05 結腸:0.82     肝臓:0.14    肺:1.23 膀胱:0.53 腎臓:1.26 下垂体:0.24 甲状腺:0.28 副腎:- 膵臓:1.98 乳腺:0.90 唾液腺:0.36
RNA-seq 子宮:- 胎盤:- 前立腺:0.06 卵巣:0.09 精巣:0.40 心臓:0.13 骨格筋:0 食道:- 胃:- 腸:- 結腸:0.02     肝臓:0.16        肺:0.18    膀胱:- 腎臓:0.51 下垂体:- 甲状腺:0.10 副腎:0.65 膵臓:- 乳腺:0.07 唾液腺:-

IDs

Refseq ID NM_004119
Gene ID 2322
Unigene ID Hs.507590
Probe set ID 206674_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000122025
GTEx ID ENSG00000122025

オーソログ対応遺伝子

マウス[1]  NM_010229
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

2004790
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0030183  B cell differentiation
GO:0071345  cellular response to cytokine stimulus
GO:0019221  cytokine-mediated signaling pathway
GO:0030097  hemopoiesis
GO:0001776  leukocyte homeostasis
GO:0046651  lymphocyte proliferation
GO:0002318  myeloid progenitor cell differentiation
GO:0045578  negative regulation of B cell differentiation
GO:0008285  negative regulation of cell proliferation
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0008284  positive regulation of cell proliferation
GO:0043406  positive regulation of MAP kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0042531  positive regulation of tyrosine phosphorylation of STAT protein
GO:0002328  pro-B cell differentiation
GO:0002572  pro-T cell differentiation
GO:0046777  protein amino acid autophosphorylation
GO:0042981  regulation of apoptosis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005788  endoplasmic reticulum lumen
GO:0005887  integral to plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004896  cytokine receptor activity
GO:0043548  phosphoinositide 3-kinase binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0005021  vascular endothelial growth factor receptor activity