sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

詳細情報を見る

同義遺伝子名

SIRT1, SIR2L1, hSIR2, hSIRT1, SIR2-like protein 1, NAD-dependent deacetylase sirtuin-1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:20.10 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:122.70 脊柱:- 網膜:- 目:11.80 動脈:30 静脈:- リンパ節:30.30 末梢血:- 脾臓:18.90 胸腺:51.50 骨髄:19.70 脂肪:- 骨:25.60 皮膚:14.40
GeneChip 大脳:5.54 小脳:6.12 脳幹:5.34 脳梁:5.89 松果体:- 末梢神経:5.93 脊柱:5.67 網膜:- 目:- 動脈:6.02 静脈:5.95 リンパ節:6.01 末梢血:- 脾臓:6.44 胸腺:7.18 骨髄:5.71 脂肪:6.14 骨:- 皮膚:5.97
CAGE 大脳:3.21 小脳:- 脳幹:3.25 脳梁:3.37 松果体:3.48 末梢神経:- 脊柱:3.37 網膜:- 目:- 動脈:3.07 静脈:3.38 リンパ節:3.19 末梢血:- 脾臓:3.11 胸腺:3.70 骨髄:- 脂肪:3.39 骨:- 皮膚:-
RNA-seq 大脳:2.53 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.90 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.67 骨:- 皮膚:-
EST 子宮:36.50 胎盤:21.90 前立腺:11.30 卵巣:- 精巣:47.60 心臓:- 骨格筋:- 食道:- 胃:21.20 腸:64.80 結腸:17     肝臓:-        肺:24.40    膀胱:- 腎臓:10.40 下垂体:116 甲状腺:- 副腎:101.60 膵臓:44.50 乳腺:46.50 唾液腺:-
GeneChip 子宮:6.62 胎盤:6.23 前立腺:6.68 卵巣:6.62 精巣:7.23 心臓:5.87 骨格筋:6.45 食道:5.20 胃:5.93 腸:5.78 結腸:5.26 肝臓:5.98 肺:6.09 膀胱:- 腎臓:5.44 下垂体:5.79 甲状腺:6.20 副腎:6.95 膵臓:4.80 乳腺:6.23 唾液腺:5.71
CAGE 子宮:3.52 胎盤:3.22 前立腺:3.71 卵巣:3.61 精巣:3.65 心臓:3.16 骨格筋:3.54 食道:3.17 胃:- 腸:3.28 結腸:3.15     肝臓:2.92    肺:3.21 膀胱:3.65 腎臓:3.12 下垂体:3.27 甲状腺:3.02 副腎:- 膵臓:2.86 乳腺:3.12 唾液腺:2.12
RNA-seq 子宮:- 胎盤:- 前立腺:3.08 卵巣:3.57 精巣:3.45 心臓:2.44 骨格筋:2.86 食道:- 胃:- 腸:- 結腸:3.27     肝臓:1.21        肺:2.59    膀胱:- 腎臓:2.61 下垂体:- 甲状腺:3.17 副腎:1.85 膵臓:- 乳腺:2.53 唾液腺:-

IDs

Refseq ID NM_012238
Gene ID 23411
Unigene ID Hs.369779
Probe set ID 218878_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000096717
GTEx ID ENSG00000096717

オーソログ対応遺伝子

マウス[3]  NM_001159589, NM_001159590, NM_019812
ラット[3]  NM_001159589, NM_001159590, NM_019812

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

10381378
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11230166
11672522
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007569  cell aging
GO:0001678  cellular glucose homeostasis
GO:0070301  cellular response to hydrogen peroxide
GO:0071456  cellular response to hypoxia
GO:0071479  cellular response to ionizing radiation
GO:0009267  cellular response to starvation
GO:0071356  cellular response to tumor necrosis factor
GO:0042632  cholesterol homeostasis
GO:0006342  chromatin silencing
GO:0000183  chromatin silencing at rDNA
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006281  DNA repair
GO:0006260  DNA replication
GO:0000731  DNA synthesis during DNA repair
GO:0006343  establishment of chromatin silencing
GO:0055089  fatty acid homeostasis
GO:0016575  histone deacetylation
GO:0070932  histone H3 deacetylation
GO:0006344  maintenance of chromatin silencing
GO:0006346  methylation-dependent chromatin silencing
GO:0007517  muscle organ development
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0030308  negative regulation of cell growth
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045599  negative regulation of fat cell differentiation
GO:0051097  negative regulation of helicase activity
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0042326  negative regulation of phosphorylation
GO:0031393  negative regulation of prostaglandin biosynthetic process
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0032007  negative regulation of TOR signaling pathway
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0001542  ovulation from ovarian follicle
GO:0018394  peptidyl-lysine acetylation
GO:0034983  peptidyl-lysine deacetylation
GO:0002821  positive regulation of adaptive immune response
GO:0043065  positive regulation of apoptosis
GO:0043280  positive regulation of caspase activity
GO:0008284  positive regulation of cell proliferation
GO:0010875  positive regulation of cholesterol efflux
GO:0031937  positive regulation of chromatin silencing
GO:0045739  positive regulation of DNA repair
GO:0046628  positive regulation of insulin receptor signaling pathway
GO:0016239  positive regulation of macroautophagy
GO:0045348  positive regulation of MHC class II biosynthetic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0043161  proteasomal ubiquitin-dependent protein catabolic process
GO:0006471  protein amino acid ADP-ribosylation
GO:0006476  protein amino acid deacetylation
GO:0031648  protein destabilization
GO:0016567  protein ubiquitination
GO:0000720  pyrimidine dimer repair by nucleotide-excision repair
GO:0070857  regulation of bile acid biosynthetic process
GO:0042127  regulation of cell proliferation
GO:0032071  regulation of endodeoxyribonuclease activity
GO:0010906  regulation of glucose metabolic process
GO:0007346  regulation of mitotic cell cycle
GO:0033158  regulation of protein import into nucleus, translocation
GO:0080134  regulation of response to stress
GO:0034391  regulation of smooth muscle cell apoptosis
GO:0006974  response to DNA damage stimulus
GO:0032868  response to insulin stimulus
GO:0006979  response to oxidative stress
GO:0006364  rRNA processing
GO:0000012  single strand break repair
GO:0007283  spermatogenesis
GO:0006351  transcription, DNA-dependent
GO:0006642  triglyceride mobilization
GO:0019048  virus-host interaction
GO:0050872  white fat cell differentiation

Cellular Component

GO:0005677  chromatin silencing complex
GO:0005737  cytoplasm
GO:0035098  ESC/E(Z) complex
GO:0000790  nuclear chromatin
GO:0005635  nuclear envelope
GO:0005719  nuclear euchromatin
GO:0005720  nuclear heterochromatin
GO:0005637  nuclear inner membrane
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0016605  PML body
GO:0033553  rDNA heterochromatin

Molecular Function

GO:0043425  bHLH transcription factor binding
GO:0019213  deacetylase activity
GO:0042393  histone binding
GO:0004407  histone deacetylase activity
GO:0043398  HLH domain binding
GO:0042802  identical protein binding
GO:0046872  metal ion binding
GO:0051019  mitogen-activated protein kinase binding
GO:0070403  NAD binding
GO:0003950  NAD+ ADP-ribosyltransferase activity
GO:0017136  NAD-dependent histone deacetylase activity
GO:0046969  NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0034979  NAD-dependent protein deacetylase activity
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0033558  protein deacetylase activity
GO:0003714  transcription corepressor activity