sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

詳細情報を見る

同義遺伝子名

SIRT1, SIR2L1, hSIR2, hSIRT1, SIR2-like protein 1, NAD-dependent deacetylase sirtuin-1

正常組織・臓器 40分類
細胞株・初代培養細胞・成体組織・胎児組織 (FANTOM5 CAGE)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:20.10

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:122.70

脊柱:-

網膜:-

目:11.80

動脈:30

静脈:-

リンパ節:30.30

末梢血:-

脾臓:18.90

胸腺:51.50

骨髄:19.70

脂肪:-

骨:25.60

皮膚:14.40

GeneChip

大脳:5.54

小脳:6.12

脳幹:5.34

脳梁:5.89

松果体:-

末梢神経:5.93

脊柱:5.67

網膜:-

目:-

動脈:6.02

静脈:5.95

リンパ節:6.01

末梢血:-

脾臓:6.44

胸腺:7.18

骨髄:5.71

脂肪:6.14

骨:-

皮膚:5.97

CAGE

大脳:3.21

小脳:-

脳幹:3.25

脳梁:3.37

松果体:3.48

末梢神経:-

脊柱:3.37

網膜:-

目:-

動脈:3.07

静脈:3.38

リンパ節:3.19

末梢血:-

脾臓:3.11

胸腺:3.70

骨髄:-

脂肪:3.39

骨:-

皮膚:-

RNA-seq

大脳:2.53

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:2.90

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:2.67

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:36.50

胎盤:21.90

前立腺:11.30

卵巣:-

精巣:47.60

心臓:-

骨格筋:-

食道:-

胃:21.20

腸:64.80

結腸:17

肝臓:-

肺:24.40

膀胱:-

腎臓:10.40

下垂体:116

甲状腺:-

副腎:101.60

膵臓:44.50

乳腺:46.50

唾液腺:-

GeneChip

子宮:6.62

胎盤:6.23

前立腺:6.68

卵巣:6.62

精巣:7.23

心臓:5.87

骨格筋:6.45

食道:5.20

胃:5.93

腸:5.78

結腸:5.26

肝臓:5.98

肺:6.09

膀胱:-

腎臓:5.44

下垂体:5.79

甲状腺:6.20

副腎:6.95

膵臓:4.80

乳腺:6.23

唾液腺:5.71

CAGE

子宮:3.52

胎盤:3.22

前立腺:3.71

卵巣:3.61

精巣:3.65

心臓:3.16

骨格筋:3.54

食道:3.17

胃:-

腸:3.28

結腸:3.15

肝臓:2.92

肺:3.21

膀胱:3.65

腎臓:3.12

下垂体:3.27

甲状腺:3.02

副腎:-

膵臓:2.86

乳腺:3.12

唾液腺:2.12

RNA-seq

子宮:-

胎盤:-

前立腺:3.08

卵巣:3.57

精巣:3.45

心臓:2.44

骨格筋:2.86

食道:-

胃:-

腸:-

結腸:3.27

肝臓:1.21

肺:2.59

膀胱:-

腎臓:2.61

下垂体:-

甲状腺:3.17

副腎:1.85

膵臓:-

乳腺:2.53

唾液腺:-

IDs

Refseq ID	NM_012238
Gene ID	23411
Unigene ID	Hs.369779
Probe set ID	218878_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000096717
GTEx ID	ENSG00000096717

オーソログ対応遺伝子

マウス[3]	NM_001159589, NM_001159590, NM_019812
ラット[3]	NM_001159589, NM_001159590, NM_019812

染色体

10q21.3 [69,644,427 - 69,678,147]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR003000

NAD-dependent histone deacetylase, silent information regulator Sir2

遺伝子オントロジー (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0007569	cell aging
GO:0001678	cellular glucose homeostasis
GO:0070301	cellular response to hydrogen peroxide
GO:0071456	cellular response to hypoxia
GO:0071479	cellular response to ionizing radiation
GO:0009267	cellular response to starvation
GO:0071356	cellular response to tumor necrosis factor
GO:0042632	cholesterol homeostasis
GO:0006342	chromatin silencing
GO:0000183	chromatin silencing at rDNA
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006281	DNA repair
GO:0006260	DNA replication
GO:0000731	DNA synthesis during DNA repair
GO:0006343	establishment of chromatin silencing
GO:0055089	fatty acid homeostasis
GO:0016575	histone deacetylation
GO:0070932	histone H3 deacetylation
GO:0006344	maintenance of chromatin silencing
GO:0006346	methylation-dependent chromatin silencing
GO:0007517	muscle organ development
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0043066	negative regulation of apoptosis
GO:0030308	negative regulation of cell growth
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045599	negative regulation of fat cell differentiation
GO:0051097	negative regulation of helicase activity
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0042326	negative regulation of phosphorylation
GO:0031393	negative regulation of prostaglandin biosynthetic process
GO:0051898	negative regulation of protein kinase B signaling cascade
GO:0032007	negative regulation of TOR signaling pathway
GO:0043433	negative regulation of transcription factor activity
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0001542	ovulation from ovarian follicle
GO:0018394	peptidyl-lysine acetylation
GO:0034983	peptidyl-lysine deacetylation
GO:0002821	positive regulation of adaptive immune response
GO:0043065	positive regulation of apoptosis
GO:0043280	positive regulation of caspase activity
GO:0008284	positive regulation of cell proliferation
GO:0010875	positive regulation of cholesterol efflux
GO:0031937	positive regulation of chromatin silencing
GO:0045739	positive regulation of DNA repair
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0016239	positive regulation of macroautophagy
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
GO:0006471	protein amino acid ADP-ribosylation
GO:0006476	protein amino acid deacetylation
GO:0031648	protein destabilization
GO:0016567	protein ubiquitination
GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
GO:0070857	regulation of bile acid biosynthetic process
GO:0042127	regulation of cell proliferation
GO:0032071	regulation of endodeoxyribonuclease activity
GO:0010906	regulation of glucose metabolic process
GO:0007346	regulation of mitotic cell cycle
GO:0033158	regulation of protein import into nucleus, translocation
GO:0080134	regulation of response to stress
GO:0034391	regulation of smooth muscle cell apoptosis
GO:0006974	response to DNA damage stimulus
GO:0032868	response to insulin stimulus
GO:0006979	response to oxidative stress
GO:0006364	rRNA processing
GO:0000012	single strand break repair
GO:0007283	spermatogenesis
GO:0006351	transcription, DNA-dependent
GO:0006642	triglyceride mobilization
GO:0019048	virus-host interaction
GO:0050872	white fat cell differentiation

Cellular Component

GO:0005677	chromatin silencing complex
GO:0005737	cytoplasm
GO:0035098	ESC/E(Z) complex
GO:0000790	nuclear chromatin
GO:0005635	nuclear envelope
GO:0005719	nuclear euchromatin
GO:0005720	nuclear heterochromatin
GO:0005637	nuclear inner membrane
GO:0005730	nucleolus
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0016605	PML body
GO:0033553	rDNA heterochromatin

Molecular Function

GO:0043425	bHLH transcription factor binding
GO:0019213	deacetylase activity
GO:0042393	histone binding
GO:0004407	histone deacetylase activity
GO:0043398	HLH domain binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0051019	mitogen-activated protein kinase binding
GO:0070403	NAD binding
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0017136	NAD-dependent histone deacetylase activity
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0034979	NAD-dependent protein deacetylase activity
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0033558	protein deacetylase activity
GO:0003714	transcription corepressor activity

sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function