hairy/enhancer-of-split related with YRPW motif 2

 詳細情報を見る

同義遺伝子名

Hairy/enhancer-of-split related with YRPW motif 2, Hairy-related transcription factor 2, CHF1, Cardiovascular helix-loop-helix factor 1, Protein gridlock homolog, GRL, hairy/enhancer-of-split related with YRPW motif 2, HESR-2, HES-related repressor protein 2, HERP, HEY2, MGC10720, HERP1, Hairy and enhancer of split-related protein 2, HRT2, HESR2

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:10.70 小脳:12.60 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:112.30 網膜:- 目:35.30 動脈:60 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:12.80 皮膚:4.80
GeneChip 大脳:5.66 小脳:5.25 脳幹:5.67 脳梁:5.91 松果体:- 末梢神経:7.03 脊柱:6.70 網膜:- 目:- 動脈:6.94 静脈:6.72 リンパ節:4.64 末梢血:- 脾臓:4.77 胸腺:4.26 骨髄:4.68 脂肪:5.09 骨:- 皮膚:4.74
CAGE 大脳:2.35 小脳:- 脳幹:2.61 脳梁:3.07 松果体:1.62 末梢神経:- 脊柱:3.05 網膜:- 目:- 動脈:4.02 静脈:1.53 リンパ節:0.69 末梢血:- 脾臓:1.24 胸腺:0.42 骨髄:- 脂肪:1.79 骨:- 皮膚:-
RNA-seq 大脳:1.60 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.43 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.37 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:9.10 胎盤:18.20 前立腺:- 卵巣:37.30 精巣:8.70 心臓:- 骨格筋:20.10 食道:- 胃:21.20 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:9.30 唾液腺:-
GeneChip 子宮:6.31 胎盤:5.17 前立腺:4.89 卵巣:6.33 精巣:5.21 心臓:6.17 骨格筋:5.78 食道:4.87 胃:4.87 腸:5.38 結腸:5.53 肝臓:5.30 肺:4.77 膀胱:- 腎臓:5.10 下垂体:5.42 甲状腺:4.64 副腎:4.77 膵臓:4.98 乳腺:5.64 唾液腺:4.78
CAGE 子宮:2.70 胎盤:1.25 前立腺:1.56 卵巣:2.68 精巣:2.35 心臓:3.21 骨格筋:3.43 食道:1.46 胃:- 腸:1.27 結腸:1.22     肝臓:1.63    肺:1.49 膀胱:1.80 腎臓:1.94 下垂体:2.19 甲状腺:1.38 副腎:- 膵臓:0.58 乳腺:2.02 唾液腺:0
RNA-seq 子宮:- 胎盤:- 前立腺:1.20 卵巣:2.73 精巣:3.19 心臓:3.24 骨格筋:2.29 食道:- 胃:- 腸:- 結腸:1.31     肝臓:0.65        肺:1.57    膀胱:- 腎臓:1.43 下垂体:- 甲状腺:1.75 副腎:1.19 膵臓:- 乳腺:2.46 唾液腺:-

詳細情報

IDs

Refseq ID NM_012259
Gene ID 23493
Unigene ID Hs.144287
Probe set ID 219743_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135547
GTEx ID ENSG00000135547

オーソログ対応遺伝子

マウス[1]  NM_013904
ラット [0]  

染色体

6q22.31  [126,068,810  -  126,082,415]

遺伝子ファミリー (Interpro ID)

IPR003650  Orange
IPR018352  Orange subgroup

Link to Pubmed  (Pubmed ID)

10415358
10692439
10710309
10860664
10924525
11095750
11486044
11486045
12372254
12477932
12535671
12548545
14574404
15389319
15485867
15489334
15643620
15680351
15821257
16043483
16151017
16165016
16189514
16293227
16329098
17217622
17611704
18239137
18266235
21290414
21362320
22310065
23275563
23744056
23872634
24108462
24366871

遺伝子オントロジー  (GO ID)

Biological Process

GO:0009948  anterior/posterior axis specification
GO:0060842  arterial endothelial cell differentiation
GO:0060413  atrial septum morphogenesis
GO:0003171  atrioventricular valve development
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0003214  cardiac left ventricle morphogenesis
GO:0014898  cardiac muscle hypertrophy in response to stress
GO:0003215  cardiac right ventricle morphogenesis
GO:0060411  cardiac septum morphogenesis
GO:0060948  cardiac vascular smooth muscle cell development
GO:0003208  cardiac ventricle morphogenesis
GO:0045165  cell fate commitment
GO:0090102  cochlea development
GO:0060977  coronary vasculature morphogenesis
GO:0003199  endocardial cushion to mesenchymal transition involved in valve formation
GO:0060347  heart trabecula formation
GO:0060716  labyrinthine layer blood vessel development
GO:0014031  mesenchymal cell development
GO:0003150  muscular septum morphogenesis
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0010629  negative regulation of gene expression
GO:0045746  negative regulation of Notch signaling pathway
GO:0010621  negative regulation of transcription by transcription factor localization
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0060633  negative regulation of transcription initiation from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007219  Notch signaling pathway
GO:0003151  outflow tract morphogenesis
GO:0060045  positive regulation of cardiac muscle cell proliferation
GO:0010460  positive regulation of heart rate
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0065004  protein-DNA complex assembly
GO:0003184  pulmonary valve morphogenesis
GO:0045607  regulation of auditory receptor cell differentiation
GO:0051145  smooth muscle cell differentiation
GO:0003195  tricuspid valve formation
GO:0003186  tricuspid valve morphogenesis
GO:0001570  vasculogenesis
GO:0055015  ventricular cardiac muscle cell development
GO:0060412  ventricular septum morphogenesis
GO:0003222  ventricular trabecular myocardium morphogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0016580  Sin3 complex
GO:0017053  transcriptional repressor complex

Molecular Function

GO:0042826  histone deacetylase binding
GO:0005515  protein binding
GO:0046983  protein dimerization activity
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding