mechanistic target of rapamycin (serine/threonine kinase)

 詳細情報を見る

同義遺伝子名

RAPT1, Mammalian target of rapamycin, FRAP, FLJ44809, FKBP12-rapamycin complex-associated protein, mTOR, FRAP2, MTOR, Rapamycin target protein, FRAP1, RAFT1

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:47.40 小脳:75.60 脳幹:- 脳梁:58.30 松果体:148.30 末梢神経:- 脊柱:- 網膜:118.60 目:70.50 動脈:89.90 静脈:- リンパ節:131.40 末梢血:18.20 脾臓:18.90 胸腺:64.40 骨髄:98.40 脂肪:121 骨:38.40 皮膚:62.40
GeneChip 大脳:5.36 小脳:5.40 脳幹:5.51 脳梁:4.95 松果体:- 末梢神経:5.04 脊柱:4.96 網膜:- 目:- 動脈:5.21 静脈:4.95 リンパ節:5.36 末梢血:- 脾臓:4.99 胸腺:5.48 骨髄:5.07 脂肪:5.18 骨:- 皮膚:5.38
CAGE 大脳:2.94 小脳:- 脳幹:2.83 脳梁:3.05 松果体:2.97 末梢神経:- 脊柱:2.65 網膜:- 目:- 動脈:2.92 静脈:2.16 リンパ節:2.67 末梢血:- 脾臓:2.41 胸腺:2.84 骨髄:- 脂肪:2.48 骨:- 皮膚:-
RNA-seq 大脳:2.94 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.60 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.82 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:63.80 胎盤:54.60 前立腺:67.60 卵巣:37.30 精巣:125.50 心臓:38.30 骨格筋:20.10 食道:- 胃:- 腸:- 結腸:59.40     肝臓:31.70        肺:48.90    膀胱:- 腎臓:10.40 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:55.80 唾液腺:-
GeneChip 子宮:5.16 胎盤:4.88 前立腺:5.53 卵巣:5.02 精巣:6.69 心臓:5.20 骨格筋:5.98 食道:5.19 胃:5.12 腸:5.02 結腸:5.06 肝臓:5.50 肺:4.98 膀胱:- 腎臓:5.51 下垂体:5.21 甲状腺:5.16 副腎:5.41 膵臓:5.01 乳腺:5.14 唾液腺:5.29
CAGE 子宮:2.73 胎盤:2.55 前立腺:2.36 卵巣:2.27 精巣:3.74 心臓:2.66 骨格筋:2.81 食道:2.47 胃:- 腸:2.53 結腸:2.72     肝臓:3.00    肺:2.34 膀胱:2.16 腎臓:2.51 下垂体:2.34 甲状腺:2.21 副腎:- 膵臓:2.86 乳腺:2.91 唾液腺:2.88
RNA-seq 子宮:- 胎盤:- 前立腺:2.68 卵巣:2.70 精巣:4.47 心臓:2.92 骨格筋:4.37 食道:- 胃:- 腸:- 結腸:2.41     肝臓:2.65        肺:1.94    膀胱:- 腎臓:3.10 下垂体:- 甲状腺:3.23 副腎:2.87 膵臓:- 乳腺:2.61 唾液腺:-

詳細情報

IDs

Refseq ID NM_004958
Gene ID 2475
Unigene ID Hs.338207
Probe set ID 202288_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000198793
GTEx ID ENSG00000198793

オーソログ対応遺伝子

マウス[2]  NM_020009
ラット [0]  

染色体

1p36.22  [11,166,592  -  11,322,608]

遺伝子ファミリー (Interpro ID)

IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic
IPR014009  PIK-related kinase
IPR011009  Protein kinase-like domain

Link to Pubmed  (Pubmed ID)

7539137
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0016049  cell growth
GO:0071456  cellular response to hypoxia
GO:0031669  cellular response to nutrient levels
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0007281  germ cell development
GO:0040007  growth
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0010507  negative regulation of autophagy
GO:0045792  negative regulation of cell size
GO:0016242  negative regulation of macroautophagy
GO:0051534  negative regulation of NFAT protein import into nucleus
GO:0048011  nerve growth factor receptor signaling pathway
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0048015  phosphoinositide-mediated signaling
GO:0016310  phosphorylation
GO:0030838  positive regulation of actin filament polymerization
GO:0001938  positive regulation of endothelial cell proliferation
GO:0010628  positive regulation of gene expression
GO:0010592  positive regulation of lamellipodium assembly
GO:0046889  positive regulation of lipid biosynthetic process
GO:0010831  positive regulation of myotube differentiation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0051496  positive regulation of stress fiber formation
GO:0045945  positive regulation of transcription from RNA polymerase III promoter
GO:0045727  positive regulation of translation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0030163  protein catabolic process
GO:0032956  regulation of actin cytoskeleton organization
GO:0043610  regulation of carbohydrate utilization
GO:0031998  regulation of fatty acid beta-oxidation
GO:0005979  regulation of glycogen biosynthetic process
GO:0045859  regulation of protein kinase activity
GO:0032314  regulation of Rac GTPase activity
GO:0032095  regulation of response to food
GO:0043200  response to amino acid stimulus
GO:0007584  response to nutrient
GO:0006950  response to stress
GO:0031529  ruffle organization
GO:0007165  signal transduction
GO:0031295  T cell costimulation
GO:0031929  TOR signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0012505  endomembrane system
GO:0005789  endoplasmic reticulum membrane
GO:0000139  Golgi membrane
GO:0005764  lysosome
GO:0016020  membrane
GO:0005741  mitochondrial outer membrane
GO:0070438  mTOR-FKBP12 complex
GO:0005942  phosphoinositide 3-kinase complex
GO:0016605  PML body
GO:0031931  TORC1 complex
GO:0031932  TORC2 complex

Molecular Function

GO:0005524  ATP binding
GO:0008144  drug binding
GO:0016301  kinase activity
GO:0051219  phosphoprotein binding
GO:0005515  protein binding
GO:0019904  protein domain specific binding
GO:0004674  protein serine/threonine kinase activity
GO:0043022  ribosome binding