proprotein convertase subtilisin/kexin type 9

詳細情報を見る

同義遺伝子名

NARC1, PSEC0052, PCSK9, Neural apoptosis-regulated convertase 1, proprotein convertase subtilisin/kexin type 9, Proprotein convertase PC9, NARC-1, FH3, HCHOLA3, Subtilisin/kexin-like protease PC9

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:19 小脳:151.10 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:4.80
GeneChip nodata
CAGE 大脳:0.28 小脳:- 脳幹:0.66 脳梁:0 松果体:0.47 末梢神経:- 脊柱:0 網膜:- 目:- 動脈:0.34 静脈:0.18 リンパ節:0.31 末梢血:- 脾臓:0.09 胸腺:0 骨髄:- 脂肪:0 骨:- 皮膚:-
RNA-seq 大脳:0.01 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.10 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:74.50 精巣:- 心臓:- 骨格筋:- 食道:- 胃:21.20 腸:- 結腸:25.40     肝臓:52.80        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:18.60 唾液腺:-
GeneChip nodata
CAGE 子宮:0.27 胎盤:0 前立腺:0 卵巣:0.07 精巣:0.19 心臓:0 骨格筋:0 食道:1.83 胃:- 腸:1.77 結腸:1.10     肝臓:3.69    肺:2.88 膀胱:0.26 腎臓:0.08 下垂体:0 甲状腺:0 副腎:- 膵臓:2.41 乳腺:0 唾液腺:0
RNA-seq 子宮:- 胎盤:- 前立腺:0.04 卵巣:0.03 精巣:0.36 心臓:0.01 骨格筋:0 食道:- 胃:- 腸:- 結腸:0.16     肝臓:4.40        肺:1.25    膀胱:- 腎臓:0.08 下垂体:- 甲状腺:0.03 副腎:0.09 膵臓:- 乳腺:0.01 唾液腺:-

IDs

Refseq ID NM_174936
Gene ID 255738
Unigene ID Hs.18844
Probe set ID -
Ensembl ID ENSG00000169174
GTEx ID ENSG00000169174

オーソログ対応遺伝子

マウス[1]  NM_153565
ラット[1]  NM_199253

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

10205269
12477932
12552133
12730697
14622975
14702039
14727156
14727179
15099351
15166014
15178557
15358785
15654334
15741654
15772090
15893176
16159606
16183066
16211558
16224054
16314752
16344560
16407292
16465619
16554528
16571601
16619215
16875509
16909389
16912035
16989838
17051583
17080197
17081983
17101087
17142622
17170371
17316651
17328821
17351764
17391637
17435765
17449864
17452316
17461796
17495605
17502100
17537735
17539906
17550346
17599443
17645871
17702855
17765244
17804797
17940607
17971861
18006936
18028451
18039650
18039658
18052825
18193043
18193044
18197702
18245819
18250299
18262190
18266662
18280815
18300938
18343176
18343183
18354102
18354137
18355829
18406350
18436227
18498363
18499582
18559913
18570182
18631360
18649882
18652535
18660751
18675252
18680192
18708425
18710658
18753623
18799458
19001363
19022446
19060325
19060906
19081568
19148283
19179626
19191301
19191720
19196236
19198609
19222187
19224862
19265033
19282863
19319977
19336475
19351729
19578796
19619878
19635789
19667110
19687008
19713274
19762784
19773416
19797716
19828345
19843101
19878649
19913121
19917273
19948975
20006333
20031582
20031607
20145306
20163833
20167577
20172854
20186155
20236128
20308432
20333646
20400780
20448210
20452593
20453200
20498851
20529551
20538126
20571754
20579540
20589640
20619837
20623344
20628086
20677014
20679960
20686565
20691829
20699424
20714348
20716520
20734064
20738937
20864672
20884874
20937814
20971364
20972250
21040917
21069265
21115573
21122852
21122860
21147780
21149300
21196532
21324305
21332221
21378990
21497351
21502677
21539517
21596380
21619378
21692990
21763412
21771976
21805236
21805237
21813713
21829380
21847580
21889145
21920719
21963094
22001517
22005270
22027821
22074827
22081141
22095935
22176652
22207727
22286219
22288532
22300679
22331829
22375030
22417841
22460556
22493497
22544364
22611251
22679642
22683120
22683370
22714699
22764087
22809551
22825241
22848640
22875854
22916037
23085658
23105118
23106476
23135270
23283366
23300213
23308045
23329883
23333725
23380568
23380588
23400816
23422832
23430252
23450051
23466067
23499248
23509406
23535506
23537802
23553812
23559630
23593297
23623011
23663650
23669246
23675525
23726366
23743349
23775089
23788249
23817198
24097068
24103783
24122718
24134510
24144304
24225950
24308640
24315769
24404629
24486405
24625727

遺伝子オントロジー  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0032869  cellular response to insulin stimulus
GO:0009267  cellular response to starvation
GO:0042632  cholesterol homeostasis
GO:0008203  cholesterol metabolic process
GO:0006917  induction of apoptosis
GO:0001822  kidney development
GO:0042157  lipoprotein metabolic process
GO:0001889  liver development
GO:0032802  low-density lipoprotein receptor catabolic process
GO:0007041  lysosomal transport
GO:0043086  negative regulation of catalytic activity
GO:0010989  negative regulation of low-density lipoprotein particle clearance
GO:0001920  negative regulation of receptor recycling
GO:0022008  neurogenesis
GO:0030182  neuron differentiation
GO:0006644  phospholipid metabolic process
GO:0043525  positive regulation of neuron apoptosis
GO:0002092  positive regulation of receptor internalization
GO:0016540  protein autoprocessing
GO:0006508  proteolysis
GO:0032803  regulation of low-density lipoprotein receptor catabolic process
GO:0043523  regulation of neuron apoptosis
GO:0010469  regulation of receptor activity
GO:0006641  triglyceride metabolic process

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005769  early endosome
GO:0005783  endoplasmic reticulum
GO:0005615  extracellular space
GO:0031232  extrinsic to external side of plasma membrane
GO:0005794  Golgi apparatus
GO:0005770  late endosome
GO:0005764  lysosome
GO:0048471  perinuclear region of cytoplasm
GO:0005791  rough endoplasmic reticulum

Molecular Function

GO:0034185  apolipoprotein binding
GO:0034190  apolipoprotein receptor binding
GO:0042802  identical protein binding
GO:0030169  low-density lipoprotein binding
GO:0050750  low-density lipoprotein receptor binding
GO:0005515  protein binding
GO:0043621  protein self-association
GO:0004252  serine-type endopeptidase activity
GO:0019871  sodium channel inhibitor activity
GO:0034189  very-low-density lipoprotein binding
GO:0070326  very-low-density lipoprotein receptor binding