APEX nuclease (multifunctional DNA repair enzyme) 1

詳細情報を見る

同義遺伝子名

APEX1, APEX nuclease, REF-1 protein, APE, APEX, REF1, AP endonuclease 1, APX, REF-1, DNA-(apurinic or apyrimidinic site) lyase, APE1, APEN

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:129.20 小脳:214.10 脳幹:- 脳梁:58.30 松果体:445 末梢神経:- 脊柱:112.30 網膜:- 目:105.80 動脈:89.90 静脈:- リンパ節:121.30 末梢血:164 脾臓:245.80 胸腺:38.70 骨髄:59 脂肪:161.30 骨:127.90 皮膚:225.60
GeneChip 大脳:8.14 小脳:8.10 脳幹:8.23 脳梁:8.10 松果体:- 末梢神経:8.37 脊柱:8.21 網膜:- 目:- 動脈:8.16 静脈:8.21 リンパ節:8.63 末梢血:- 脾臓:8.41 胸腺:9.07 骨髄:8.86 脂肪:8.62 骨:- 皮膚:8.76
CAGE 大脳:4.37 小脳:- 脳幹:4.37 脳梁:4.54 松果体:4.57 末梢神経:- 脊柱:4.44 網膜:- 目:- 動脈:4.20 静脈:4.64 リンパ節:4.65 末梢血:- 脾臓:4.78 胸腺:5.01 骨髄:- 脂肪:4.72 骨:- 皮膚:-
RNA-seq 大脳:2.73 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.60 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.61 骨:- 皮膚:-
EST 子宮:118.50 胎盤:262.30 前立腺:67.60 卵巣:37.30 精巣:30.30 心臓:242.70 骨格筋:60.30 食道:- 胃:212.40 腸:194.40 結腸:237.40     肝臓:52.80        肺:190.60    膀胱:125.60 腎臓:93.60 下垂体:116 甲状腺:- 副腎:304.70 膵臓:26.70 乳腺:130.10 唾液腺:-
GeneChip 子宮:8.93 胎盤:7.62 前立腺:8.73 卵巣:9.19 精巣:7.44 心臓:7.94 骨格筋:8.29 食道:8.47 胃:8.35 腸:8.54 結腸:8.64 肝臓:8.08 肺:8.08 膀胱:- 腎臓:8.39 下垂体:8.05 甲状腺:8.66 副腎:8.73 膵臓:8.70 乳腺:9.03 唾液腺:8.14
CAGE 子宮:4.71 胎盤:4.16 前立腺:4.52 卵巣:4.86 精巣:4.07 心臓:4.24 骨格筋:4.80 食道:4.59 胃:- 腸:4.48 結腸:4.56     肝臓:4.79    肺:4.38 膀胱:4.61 腎臓:4.64 下垂体:4.03 甲状腺:4.74 副腎:- 膵臓:4.47 乳腺:3.69 唾液腺:4.53
RNA-seq 子宮:- 胎盤:- 前立腺:3.26 卵巣:4.52 精巣:3.04 心臓:2.82 骨格筋:1.23 食道:- 胃:- 腸:- 結腸:2.46     肝臓:3.71        肺:0.00    膀胱:- 腎臓:1.54 下垂体:- 甲状腺:4.27 副腎:4.93 膵臓:- 乳腺:2.97 唾液腺:-

IDs

Refseq ID NM_080648
Gene ID 328
Unigene ID Hs.73722
Probe set ID 210027_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100823
GTEx ID ENSG00000100823

オーソログ対応遺伝子

マウス[3]  NM_009687
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1284593
1371347
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0007568  aging
GO:0006284  base-excision repair
GO:0045454  cell redox homeostasis
GO:0071320  cellular response to cAMP
GO:0070301  cellular response to hydrogen peroxide
GO:0071375  cellular response to peptide hormone stimulus
GO:0080111  DNA demethylation
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0014912  negative regulation of smooth muscle cell migration
GO:0055114  oxidation reduction
GO:0045739  positive regulation of DNA repair
GO:0043488  regulation of mRNA stability
GO:0006355  regulation of transcription, DNA-dependent
GO:0042493  response to drug
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0005739  mitochondrion
GO:0016607  nuclear speck
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005840  ribosome
GO:0005667  transcription factor complex

Molecular Function

GO:0008408  3'-5' exonuclease activity
GO:0031490  chromatin DNA binding
GO:0003684  damaged DNA binding
GO:0003677  DNA binding
GO:0003906  DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004520  endodeoxyribonuclease activity
GO:0004519  endonuclease activity
GO:0046872  metal ion binding
GO:0051059  NF-kappaB binding
GO:0016491  oxidoreductase activity
GO:0004528  phosphodiesterase I activity
GO:0008081  phosphoric diester hydrolase activity
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0004523  ribonuclease H activity
GO:0003723  RNA binding
GO:0016890  site-specific endodeoxyribonuclease activity, specific for altered base
GO:0003713  transcription coactivator activity
GO:0003714  transcription corepressor activity
GO:0004844  uracil DNA N-glycosylase activity