insulin-like growth factor 1 (somatomedin C)

詳細情報を見る

同義遺伝子名

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発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:8.30 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:398.70 脊柱:- 網膜:- 目:29.40 動脈:30 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:80.70 骨:25.60 皮膚:4.80
GeneChip 大脳:5.97 小脳:6.28 脳幹:5.96 脳梁:5.92 松果体:- 末梢神経:6.17 脊柱:5.76 網膜:- 目:- 動脈:7.28 静脈:7.39 リンパ節:6.23 末梢血:- 脾臓:6.32 胸腺:6.12 骨髄:5.76 脂肪:7.91 骨:- 皮膚:6.55
CAGE 大脳:1.32 小脳:- 脳幹:1.63 脳梁:1.59 松果体:0.35 末梢神経:- 脊柱:1.63 網膜:- 目:- 動脈:3.49 静脈:3.71 リンパ節:3.13 末梢血:- 脾臓:2.96 胸腺:1.88 骨髄:- 脂肪:4.67 骨:- 皮膚:-
RNA-seq 大脳:0.08 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.01 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:4.12 骨:- 皮膚:-
EST 子宮:100.20 胎盤:32.80 前立腺:225.30 卵巣:372.60 精巣:17.30 心臓:102.20 骨格筋:- 食道:342.80 胃:- 腸:97.20 結腸:25.40     肝臓:31.70        肺:29.30    膀胱:- 腎臓:20.80 下垂体:- 甲状腺:- 副腎:- 膵臓:53.30 乳腺:27.90 唾液腺:-
GeneChip 子宮:9.20 胎盤:6.88 前立腺:7.78 卵巣:7.66 精巣:6.70 心臓:7.51 骨格筋:6.33 食道:6.57 胃:6.59 腸:6.61 結腸:6.72 肝臓:7.80 肺:6.40 膀胱:- 腎臓:5.77 下垂体:5.70 甲状腺:6.43 副腎:6.65 膵臓:6.61 乳腺:8.01 唾液腺:6.38
CAGE 子宮:5.11 胎盤:3.87 前立腺:5.42 卵巣:4.19 精巣:4.13 心臓:4.06 骨格筋:3.34 食道:4.11 胃:- 腸:2.34 結腸:2.85     肝臓:4.38    肺:2.92 膀胱:4.42 腎臓:2.77 下垂体:1.11 甲状腺:4.62 副腎:- 膵臓:2.54 乳腺:3.95 唾液腺:2.26
RNA-seq 子宮:- 胎盤:- 前立腺:2.73 卵巣:1.74 精巣:4.04 心臓:1.49 骨格筋:0.97 食道:- 胃:- 腸:- 結腸:2.85     肝臓:2.35        肺:0.78    膀胱:- 腎臓:0.63 下垂体:- 甲状腺:2.34 副腎:1.56 膵臓:- 乳腺:3.76 唾液腺:-

IDs

Refseq ID NM_000618
Gene ID 3479
Unigene ID Hs.160562
Probe set ID 211577_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000017427
GTEx ID ENSG00000017427

オーソログ対応遺伝子

マウス[13]  NM_001111274, NM_001111275, NM_001111276, NM_010512, NM_184052
ラット[12]  NM_001082477, NM_001082478, NM_001082479, NM_178866, NM_184052

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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23696648
23698746
23704881
23708690
23712705
23723293
23734076
23748063
23749893
23757194
23757355
23770741
23778474
23784592
23789983
23792502
23792936
23800627
23801064
23801371
23815140
23850449
23857432
23861230
23864592
23892354
23932581
23941777
23942554
23958273
23967261
23980150
23989258
23989734
24012102
24013497
24022308
24026884
24035852
24036101
24037648
24094144
24184209
24248481
24282367
24301648
24469459
24501799
24506070
24511663
24518169
24552398

遺伝子オントロジー  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0001974  blood vessel remodeling
GO:0048754  branching morphogenesis of a tube
GO:0006928  cellular component movement
GO:0044267  cellular protein metabolic process
GO:0050650  chondroitin sulfate proteoglycan biosynthetic process
GO:0006260  DNA replication
GO:0031017  exocrine pancreas development
GO:0010001  glial cell differentiation
GO:0009441  glycolate metabolic process
GO:0048839  inner ear development
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0048286  lung alveolus development
GO:0060463  lung lobe morphogenesis
GO:0060426  lung vasculature development
GO:0030879  mammary gland development
GO:0035264  multicellular organism growth
GO:0014896  muscle hypertrophy
GO:0007517  muscle organ development
GO:0045445  myoblast differentiation
GO:0051450  myoblast proliferation
GO:0014904  myotube cell development
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0090201  negative regulation of release of cytochrome c from mitochondria
GO:0034392  negative regulation of smooth muscle cell apoptosis
GO:0048015  phosphoinositide-mediated signaling
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0042104  positive regulation of activated T cell proliferation
GO:0070886  positive regulation of calcineurin-NFAT signaling pathway
GO:0010613  positive regulation of cardiac muscle hypertrophy
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0048146  positive regulation of fibroblast proliferation
GO:0046326  positive regulation of glucose import
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0045821  positive regulation of glycolysis
GO:0021940  positive regulation of granule cell precursor proliferation
GO:0043568  positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043410  positive regulation of MAPKKK cascade
GO:0045840  positive regulation of mitosis
GO:0045669  positive regulation of osteoblast differentiation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0046579  positive regulation of Ras protein signal transduction
GO:0014911  positive regulation of smooth muscle cell migration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736  prostate gland growth
GO:0060741  prostate gland stromal morphogenesis
GO:0030166  proteoglycan biosynthetic process
GO:0007265  Ras protein signal transduction
GO:0032878  regulation of establishment or maintenance of cell polarity
GO:0040014  regulation of multicellular organism growth
GO:0014834  satellite cell maintenance involved in skeletal muscle regeneration
GO:0007165  signal transduction
GO:0001501  skeletal system development
GO:0060509  Type I pneumocyte differentiation
GO:0060510  Type II pneumocyte differentiation
GO:0030104  water homeostasis

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016942  insulin-like growth factor binding protein complex
GO:0005886  plasma membrane
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0008083  growth factor activity
GO:0005179  hormone activity
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005178  integrin binding
GO:0005515  protein binding