insulin-like growth factor 1 (somatomedin C)

詳細情報を見る

同義遺伝子名

-

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:8.30 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:398.70 脊柱:- 網膜:- 目:29.40 動脈:30 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:80.70 骨:25.60 皮膚:4.80
GeneChip 大脳:4.44 小脳:3.73 脳幹:4.33 脳梁:4.04 松果体:- 末梢神経:5.04 脊柱:4.34 網膜:- 目:- 動脈:6.26 静脈:7.11 リンパ節:5.16 末梢血:- 脾臓:5.52 胸腺:4.71 骨髄:4.62 脂肪:7.98 骨:- 皮膚:5.90
CAGE 大脳:1.32 小脳:- 脳幹:1.63 脳梁:1.59 松果体:0.35 末梢神経:- 脊柱:1.63 網膜:- 目:- 動脈:3.49 静脈:3.71 リンパ節:3.13 末梢血:- 脾臓:2.96 胸腺:1.88 骨髄:- 脂肪:4.67 骨:- 皮膚:-
RNA-seq 大脳:0.00 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.57 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.39 骨:- 皮膚:-
EST 子宮:100.20 胎盤:32.80 前立腺:225.30 卵巣:372.60 精巣:17.30 心臓:102.20 骨格筋:- 食道:342.80 胃:- 腸:97.20 結腸:25.40     肝臓:31.70        肺:29.30    膀胱:- 腎臓:20.80 下垂体:- 甲状腺:- 副腎:- 膵臓:53.30 乳腺:27.90 唾液腺:-
GeneChip 子宮:9.23 胎盤:6.98 前立腺:7.66 卵巣:7.49 精巣:6.04 心臓:7.14 骨格筋:5.68 食道:5.16 胃:5.68 腸:6.37 結腸:5.89 肝臓:7.61 肺:5.23 膀胱:- 腎臓:4.09 下垂体:3.84 甲状腺:5.74 副腎:5.57 膵臓:5.47 乳腺:7.83 唾液腺:5.31
CAGE 子宮:5.11 胎盤:3.87 前立腺:5.42 卵巣:4.19 精巣:4.13 心臓:4.06 骨格筋:3.34 食道:4.11 胃:- 腸:2.34 結腸:2.85     肝臓:4.38    肺:2.92 膀胱:4.42 腎臓:2.77 下垂体:1.11 甲状腺:4.62 副腎:- 膵臓:2.54 乳腺:3.95 唾液腺:2.26
RNA-seq 子宮:- 胎盤:- 前立腺:0.28 卵巣:0.26 精巣:0.26 心臓:0.35 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:0.00     肝臓:0.49        肺:0    膀胱:- 腎臓:0.00 下垂体:- 甲状腺:0.11 副腎:0.00 膵臓:- 乳腺:0.07 唾液腺:-

IDs

Refseq ID NM_001111283
Gene ID 3479
Unigene ID Hs.160562
Probe set ID 209541_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000017427
GTEx ID ENSG00000017427

オーソログ対応遺伝子

マウス[13]  NM_001111274, NM_001111275, NM_001111276, NM_010512, NM_184052
ラット[12]  NM_001082477, NM_001082478, NM_001082479, NM_178866, NM_184052

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

632300
1147105
1319992
1370435
1372070
1383255
1733942
1791841
1852007
2018498
2036417
2082190
2752154
2935423
2937782
2982726
3002851
3242681
3455760
3683205
4550398
6189745
6358902
6382022
7188854
7511544
7683646
7688386
7692086
7720641
7782332
7916968
8421089
8452530
8495408
8857020
8939990
9138096
9446566
9453236
9497324
9681507
9722506
9722589
9831081
9853872
9857239
10084601
10191278
10205209
10226805
10350456
10381171
10391209
10407151
10448861
10459853
10512690
10644978
10749889
10766744
10823924
10848592
11063745
11161840
11175789
11246885
11319179
11344214
11600567
11735247
11749962
11762714
11768601
11787050
11822578
11825899
11834727
11857446
11858767
11867942
11877395
11877670
11896491
11897674
11903419
11904589
11907830
11909998
11914023
11914026
11924928
11937187
11943599
11953210
11964397
11972897
11988840
11994280
11994678
12005306
12006706
12011046
12011225
12032677
12050240
12062094
12070137
12086966
12095637
12102164
12111701
12115549
12122101
12127559
12135130
12135360
12164325
12175483
12186542
12201212
12213898
12217887
12218293
12236578
12237896
12240900
12356750
12364325
12381752
12388463
12389335
12394769
12397390
12419777
12424437
12477932
12508915
12508916
12508917
12508918
12508929
12508940
12509920
12511011
12519841
12545204
12555073
12562960
12571183
12590635
12590636
12592062
12610514
12612059
12631341
12642873
12679458
12714114
12716804
12716855
12716875
12727948
12729801
12730416
12732844
12734180
12735930
12746292
12746903
12759337
12787886
12791939
12800944
12810534
12842994
12843178
12843179
12843187
12858577
12861174
12865482
12867429
12870155
12891709
12909598
12915683
12919702
12930919
12937269
12937290
12943991
12948293
12949013
12960100
12970325
13130502
14504195
14521955
14557458
14602779
14604834
14605256
14631161
14633859
14647921
14657423
14668202
14673951
14674122
14681231
14684598
14684690
14690534
14691011
14691340
14693733
14697248
14710345
14710346
14710359
14714750
14715837
14718574
14744783
14749262
14757186
14761840
14764950
14961074
14973173
15033176
15033949
15044591
15047131
15049048
15067513
15072640
15082485
15086466
15087580
15090033
15098919
15105834
15134305
15135045
15140223
15181035
15187095
15205474
15210945
15211595
15217931
15221500
15221971
15223841
15231015
15240644
15247132
15254679
15256490
15256976
15272501
15272914
15276114
15292338
15302288
15302582
15302607
15304489
15331555
15345670
15350139
15358562
15386404
15451424
15477425
15485651
15489542
15505506
15509657
15514031
15517912
15522943
15528386
15537892
15548698
15556609
15576456
15579776
15586244
15611085
15611844
15616244
15616898
15618451
15625284
15641262
15641264
15653207
15657590
15661050
15668470
15668488
15678496
15688209
15692088
15694994
15695599
15726267
15731363
15734965
15735081
15756256
15767261
15780948
15784711
15797461
15809062
15820831
15844470
15845624
15848608
15849510
15862031
15867218
15879687
15888547
15891958
15894537
15894673
15927083
15932773
15941947
15950665
15954927
15956340
15986122
16000303
16008890
16015705
16019437
16030120
16041536
16044163
16051222
16111879
16115888
16133873
16159864
16161053
16189249
16195423
16215864
16244494
16294334
16297654
16306136
16306230
16322331
16330010
16332723
16352683
16352686
16361587
16369467
16394092
16400188
16404426
16412381
16418515
16418517
16433617
16448675
16489531
16498050
16516166
16635594
16645019
16648498
16670160
16716263
16716629
16720666
16724947
16728464
16776662
16778368
16785149
16807888
16820871
16825188
16831875
16840657
16846747
16847815
16868142
16873705
16887362
16888814
16924115
16926156
16935391
16939403
16940243
16942485
16953217
16955207
16962112
16969385
16970944
16981855
16998819
17006543
17010055
17010800
17015410
17033263
17033713
17044098
17045571
17051426
17062892
17063263
17066319
17082888
17090643
17096324
17107821
17108398
17113753
17116217
17119061
17133354
17142521
17148586
17156777
17164371
17164408
17166846
17174724
17179152
17179726
17187018
17211256
17218729
17234973
17236585
17254778
17255202
17264182
17265493
17289286
17289909
17300730
17311016
17317669
17320297
17320874
17330866
17343577
17350302
17363178
17363459
17376820
17377396
17377412
17385724
17387582
17388800
17396115
17396438
17410466
17412783
17418605
17419944
17425608
17447118
17458902
17470458
17484040
17486636
17492509
17497031
17499312
17499363
17509524
17520698
17531227
17545516
17546465
17555512
17556532
17560154
17560457
17560756
17561390
17566087
17569567
17574386
17581609
17597108
17597610
17617058
17622956
17624368
17651480
17652764
17666408
17666470
17666477
17666480
17668637
17689128
17702838
17709895
17721831
17724372
17761791
17785698
17803702
17827385
17827393
17851271
17879951
17888024
17895313
17904522
17911177
17912004
17916769
17920708
17921143
17936052
17953371
17953960
17957164
17975158
17989724
17991453
17997337
18003755
18006148
18006928
18022169
18026134
18031946
18037753
18045956
18050312
18052685
18054929
18059035
18064566
18067523
18079194
18079201
18079751
18082739
18163429
18166823
18174288
18177247
18178497
18188667
18199422
18199734
18215180
18215216
18236213
18237549
18246120
18250100
18259111
18283040
18284609
18299470
18301972
18308828
18311789
18316619
18316725
18317720
18335323
18349294
18365879
18372285
18375957
18377765
18398029
18401200
18403642
18410545
18413316
18420583
18432248
18432585
18437163
18451573
18461658
18464752
18466350
18481170
18482854
18490653
18499368
18502759
18507054
18520331
18534134
18535190
18537700
18538283
18544576
18547344
18552658
18560445
18562769
18567511
18567578
18568888
18577518
18596909
18598695
18603571
18614962
18615538
18616667
18618736
18623088
18631396
18636124
18636198
18648544
18653547
18658030
18662893
18665784
18666027
18675202
18676680
18697743
18703768
18757322
18761080
18762812
18774952
18781172
18785005
18812263
18814240
18818748
18828733
18831980
18852162
18924579
18948617
18975254
18979395
18981102
18991569
18992148
18992263
18996102
19004037
19010705
19012097
19019335
19021034
19027918
19038795
19050262
19064126
19064563
19064572
19067728
19070892
19075184
19077426
19085695
19091070
19094228
19103645
19124506
19124510
19127217
19129715
19136503
19138871
19147602
19160571
19167357
19170196
19190540
19194113
19207031
19207313
19217707
19223521
19228610
19229608
19235591
19238412
19240240
19246276
19246485
19250636
19251054
19254914
19269948
19276999
19293573
19293581
19300521
19304869
19308628
19318457
19323791
19330922
19332270
19336370
19340002
19346116
19346585
19386527
19398211
19406747
19417076
19417744
19423701
19424673
19426107
19434535
19453261
19467892
19470256
19470380
19470623
19472023
19474142
19482057
19488994
19491931
19506539
19526274
19527514
19530221
19531281
19533653
19543094
19551864
19560785
19563785
19567392
19568604
19571555
19572220
19578119
19585556
19598235
19603014
19605357
19618660
19625176
19626396
19634593
19634821
19639489
19654000
19658040
19672706
19680783
19690970
19692168
19709092
19728079
19729319
19751734
19759555
19770497
19773182
19773405
19784788
19786462
19797396
19813164
19833751
19843326
19845745
19846733
19858071
19863750
19887603
19891769
19893584
19895315
19906888
19913121
19917654
19919531
19932628
19938957
19942582
19944347
19948975
19955757
19966181
19966862
20002733
20010316
20010501
20013271
20013551
20016970
20022575
20031461
20039319
20044479
20047081
20048152
20051649
20080855
20081858
20086250
20089844
20098680
20098959
20099280
20100838
20119675
20132087
20142246
20145156
20150439
20155489
20157552
20163445
20176597
20182617
20185807
20189936
20190159
20190537
20190549
20199671
20202860
20206398
20207740
20214787
20215395
20220546
20220555
20230795
20231902
20300125
20302654
20306690
20351102
20355242
20356932
20360006
20363874
20372799
20378848
20379614
20389101
20395543
20403354
20403997
20414942
20416304
20418654
20419449
20423985
20426845
20427254
20435602
20437058
20452482
20453000
20468064
20472480
20473871
20484221
20486202
20487628
20490824
20519361
20534752
20559971
20571236
20571754
20580999
20587610
20602615
20603485
20628086
20633033
20634197
20646497
20668042
20668872
20670935
20671417
20671418
20673868
20685093
20701471
20730440
20731527
20734064
20801067
20810576
20810604
20818748
20818790
20844834
20848182
20857406
20858702
20863877
20872173
20875825
20884247
20889360
20920870
20927124
20935157
20962507
20962685
20963499
20965827
21031436
21039458
21046444
21047277
21056746
21057699
21070767
21076856
21078522
21082354
21094246
21099256
21113804
21114510
21123448
21135552
21161940
21176999
21187969
21192914
21196777
21198739
21212012
21216879
21237682
21245137
21251749
21263374
21266309
21273576
21274339
21287667
21302346
21308753
21310824
21314261
21315112
21316352
21344385
21345666
21354439
21367536
21378090
21388493
21388950
21390492
21392749
21406062
21422735
21435927
21436142
21447628
21450456
21454954
21458314
21459641
21460230
21460853
21471532
21471542
21474915
21478207
21480260
21484083
21502796
21508132
21521288
21521316
21521322
21535073
21535266
21536469
21552154
21554807
21562710
21573718
21585623
21590732
21617253
21634360
21638027
21658593
21658978
21667186
21672348
21689549
21690232
21698457
21700939
21705978
21705979
21707534
21708381
21723061
21753778
21761353
21788435
21799000
21816784
21823995
21832856
21839662
21840378
21846339
21852217
21854509
21865155
21867981
21873172
21882221
21898383
21930730
21932337
21932422
21933314
21941959
21944866
21951159
21958043
21967317
21972777
21976954
21986483
22004906
22026507
22032863
22048966
22059359
22082268
22113073
22119913
22133783
22145451
22146489
22154520
22164296
22170795
22189999
22199289
22217530
22227802
22245162
22245250
22246875
22253814
22253890
22286784
22297468
22305966
22311343
22318747
22322534
22328165
22332214
22347413
22359227
22363400
22364960
22372631
22379117
22389002
22391565
22410945
22419724
22423511
22423513
22430216
22442270
22452985
22475139
22479346
22503243
22503545
22509095
22509107
22513191
22524398
22527168
22529373
22532606
22554827
22554965
22559791
22564703
22565227
22572840
22573330
22581228
22582495
22591999
22626951
22630333
22669976
22673406
22714057
22729283
22733797
22739332
22739988
22746182
22767591
22832530
22839688
22843623
22844419
22847383
22859931
22865898
22875667
22882716
22892437
22894543
22898392
22906275
22922215
22933025
22936258
22941977
22951368
22960989
22968245
22982059
22982320
23047741
23079385
23080092
23089282
23121326
23122221
23138182
23160066
23165777
23180020
23197045
23211593
23226206
23227848
23233113
23266941
23288662
23295542
23322062
23335048
23340251
23341348
23344457
23351407
23364988
23365126
23397154
23400010
23400497
23403580
23406753
23410103
23419423
23423640
23424195
23438236
23457723
23462604
23473966
23483175
23497056
23499762
23524620
23526299
23526983
23530598
23546957
23558432
23583271
23606700
23611528
23612968
23619263
23619527
23624134
23628798
23658892
23666343
23671040
23671288
23686362
23689439
23696648
23698746
23704881
23708690
23712705
23723293
23734076
23748063
23749893
23757194
23757355
23770741
23778474
23784592
23789983
23792502
23792936
23800627
23801064
23801371
23815140
23850449
23857432
23861230
23864592
23892354
23932581
23941777
23942554
23958273
23967261
23980150
23989258
23989734
24012102
24013497
24022308
24026884
24035852
24036101
24037648
24094144
24184209
24248481
24282367
24301648
24469459
24501799
24506070
24511663
24518169
24552398

遺伝子オントロジー  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0001974  blood vessel remodeling
GO:0048754  branching morphogenesis of a tube
GO:0006928  cellular component movement
GO:0044267  cellular protein metabolic process
GO:0050650  chondroitin sulfate proteoglycan biosynthetic process
GO:0006260  DNA replication
GO:0031017  exocrine pancreas development
GO:0010001  glial cell differentiation
GO:0009441  glycolate metabolic process
GO:0048839  inner ear development
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0048286  lung alveolus development
GO:0060463  lung lobe morphogenesis
GO:0060426  lung vasculature development
GO:0030879  mammary gland development
GO:0035264  multicellular organism growth
GO:0014896  muscle hypertrophy
GO:0007517  muscle organ development
GO:0045445  myoblast differentiation
GO:0051450  myoblast proliferation
GO:0014904  myotube cell development
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0090201  negative regulation of release of cytochrome c from mitochondria
GO:0034392  negative regulation of smooth muscle cell apoptosis
GO:0048015  phosphoinositide-mediated signaling
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0042104  positive regulation of activated T cell proliferation
GO:0070886  positive regulation of calcineurin-NFAT signaling pathway
GO:0010613  positive regulation of cardiac muscle hypertrophy
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0048146  positive regulation of fibroblast proliferation
GO:0046326  positive regulation of glucose import
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0045821  positive regulation of glycolysis
GO:0021940  positive regulation of granule cell precursor proliferation
GO:0043568  positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043410  positive regulation of MAPKKK cascade
GO:0045840  positive regulation of mitosis
GO:0045669  positive regulation of osteoblast differentiation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0046579  positive regulation of Ras protein signal transduction
GO:0014911  positive regulation of smooth muscle cell migration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736  prostate gland growth
GO:0060741  prostate gland stromal morphogenesis
GO:0030166  proteoglycan biosynthetic process
GO:0007265  Ras protein signal transduction
GO:0032878  regulation of establishment or maintenance of cell polarity
GO:0040014  regulation of multicellular organism growth
GO:0014834  satellite cell maintenance involved in skeletal muscle regeneration
GO:0007165  signal transduction
GO:0001501  skeletal system development
GO:0060509  Type I pneumocyte differentiation
GO:0060510  Type II pneumocyte differentiation
GO:0030104  water homeostasis

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016942  insulin-like growth factor binding protein complex
GO:0005886  plasma membrane
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0008083  growth factor activity
GO:0005179  hormone activity
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005178  integrin binding
GO:0005515  protein binding