interleukin 6 signal transducer (gp130, oncostatin M receptor)

詳細情報を見る

同義遺伝子名

IL6ST, IL6R-beta, CD130 antigen, CDw130, GP130-RAPS, IL-6R-beta, gp130, Membrane glycoprotein 130, CD130, Oncostatin M receptor, Interleukin 6 signal transducer, Interleukin-6 receptor beta chain precursor

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:71.10 小脳:50.40 脳幹:- 脳梁:87.50 松果体:- 末梢神経:184 脊柱:449.20 網膜:118.60 目:141 動脈:239.80 静脈:266.60 リンパ節:161.80 末梢血:182.20 脾臓:94.50 胸腺:141.70 骨髄:334.60 脂肪:40.30 骨:191.90 皮膚:163.20
GeneChip 大脳:8.77 小脳:8.47 脳幹:8.99 脳梁:9.43 松果体:- 末梢神経:9.65 脊柱:9.65 網膜:- 目:- 動脈:9.22 静脈:9.49 リンパ節:9.23 末梢血:- 脾臓:9.43 胸腺:9.32 骨髄:7.04 脂肪:9.80 骨:- 皮膚:8.87
CAGE 大脳:4.84 小脳:- 脳幹:5.12 脳梁:4.69 松果体:4.74 末梢神経:- 脊柱:5.63 網膜:- 目:- 動脈:5.24 静脈:5.15 リンパ節:5.35 末梢血:- 脾臓:5.48 胸腺:4.74 骨髄:- 脂肪:5.58 骨:- 皮膚:-
RNA-seq 大脳:0.00 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.75 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.23 骨:- 皮膚:-
EST 子宮:319 胎盤:240.40 前立腺:292.90 卵巣:186.30 精巣:95.20 心臓:293.70 骨格筋:281.30 食道:- 胃:21.20 腸:129.60 結腸:118.70     肝臓:200.60        肺:136.90    膀胱:376.80 腎臓:114.40 下垂体:347.90 甲状腺:163.70 副腎:253.90 膵臓:177.80 乳腺:167.30 唾液腺:-
GeneChip 子宮:9.88 胎盤:10.09 前立腺:9.74 卵巣:9.81 精巣:7.52 心臓:9.15 骨格筋:8.56 食道:8.16 胃:8.87 腸:8.80 結腸:7.78 肝臓:9.35 肺:9.71 膀胱:- 腎臓:8.29 下垂体:8.47 甲状腺:9.44 副腎:9.57 膵臓:7.84 乳腺:9.41 唾液腺:9.64
CAGE 子宮:5.28 胎盤:5.80 前立腺:5.44 卵巣:5.68 精巣:4.28 心臓:5.63 骨格筋:5.10 食道:5.08 胃:- 腸:4.77 結腸:5.03     肝臓:5.83    肺:5.57 膀胱:5.46 腎臓:5.49 下垂体:5.25 甲状腺:5.47 副腎:- 膵臓:4.31 乳腺:6.30 唾液腺:4.99
RNA-seq 子宮:- 胎盤:- 前立腺:2.14 卵巣:1.27 精巣:0.00 心臓:0.00 骨格筋:1.50 食道:- 胃:- 腸:- 結腸:0.00     肝臓:2.32        肺:1.09    膀胱:- 腎臓:1.61 下垂体:- 甲状腺:0.00 副腎:0.22 膵臓:- 乳腺:0.00 唾液腺:-

IDs

Refseq ID NM_175767
Gene ID 3572
Unigene ID Hs.532082
Probe set ID 212195_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000134352
GTEx ID ENSG00000134352

オーソログ対応遺伝子

マウス[3]  NM_010560
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1617725
2261637
2788034
7736792
8353278
8390097
8511589
8547494
8999038
9013873
9126968
9188471
9195977
9256256
9353320
9388212
9501088
10026196
10219240
10504396
10579793
10744750
10777583
10800945
10811661
10880057
10946280
10954742
10982829
11098061
11121117
11251120
11285233
11468294
11557047
11689697
11742534
11781191
11786531
11821958
11834704
11877042
11884403
11920233
11952536
12030375
12039911
12047380
12161539
12234945
12361954
12372336
12386808
12403768
12434062
12472176
12477932
12643274
12707266
12707269
12782602
12819039
12829785
12830005
12917504
14504285
14557255
14676217
14718574
14764685
14764690
15081423
15129430
15133123
15184896
15292206
15677447
15721840
15754404
15809742
15895091
15944400
16051226
16141642
16254248
16274960
16335952
16344560
16524883
16646038
16728717
16774741
16909117
16973585
17028186
17053039
17081983
17404609
17436251
17519976
17530315
17619842
17652155
17664290
17885560
17926108
17961593
17979974
17997171
18060032
18223637
18246092
18292582
18320358
18469182
18519587
18549508
18573283
18684959
18775332
18986700
19020503
19074885
19124510
19213859
19240061
19330911
19336475
19379608
19386761
19422646
19453261
19460752
19573080
19623024
19665497
19665805
19730683
19773279
19850743
19913121
19915009
19946888
20103703
20200229
20237496
20309664
20348091
20453842
20489211
20554759
20568250
20584990
20585009
20600579
20628086
20628624
20660911
20728947
20869059
21139048
21173340
21220115
21225514
21282511
21944124
21981268
21989726
22457856
22520363
22523320
22742541
22814105
23128233
23209286
23253440
23294003
23372742
23375201
23382691
23398366
23428306
23536726
23686311
23782174
23782265
23813018
23818941
24082147
24191003
24629561

遺伝子オントロジー  (GO ID)

Biological Process

GO:0070120  ciliary neurotrophic factor-mediated signaling pathway
GO:0019221  cytokine-mediated signaling pathway
GO:0005977  glycogen metabolic process
GO:0070106  interleukin-27-mediated signaling pathway
GO:0070102  interleukin-6-mediated signaling pathway
GO:0048861  leukemia inhibitory factor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0070104  negative regulation of interleukin-6-mediated signaling pathway
GO:0002675  positive regulation of acute inflammatory response
GO:0002821  positive regulation of adaptive immune response
GO:0048711  positive regulation of astrocyte differentiation
GO:0010613  positive regulation of cardiac muscle hypertrophy
GO:0008284  positive regulation of cell proliferation
GO:0045669  positive regulation of osteoblast differentiation
GO:0042102  positive regulation of T cell proliferation
GO:0042511  positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0010575  positive regulation vascular endothelial growth factor production
GO:0008593  regulation of Notch signaling pathway
GO:0034097  response to cytokine stimulus

Cellular Component

GO:0043025  cell soma
GO:0070110  ciliary neurotrophic factor receptor complex
GO:0030425  dendrite
GO:0009897  external side of plasma membrane
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005896  interleukin-6 receptor complex
GO:0005900  oncostatin-M receptor complex
GO:0005886  plasma membrane

Molecular Function

GO:0004897  ciliary neurotrophic factor receptor activity
GO:0005127  ciliary neurotrophic factor receptor binding
GO:0019838  growth factor binding
GO:0019970  interleukin-11 binding
GO:0004921  interleukin-11 receptor activity
GO:0045509  interleukin-27 receptor activity
GO:0019981  interleukin-6 binding
GO:0004915  interleukin-6 receptor activity
GO:0005138  interleukin-6 receptor binding
GO:0004923  leukemia inhibitory factor receptor activity
GO:0004924  oncostatin-M receptor activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity