leukemia inhibitory factor (cholinergic differentiation factor)

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同義遺伝子名

Leukemia inhibitory factor precursor, LIF, D factor, Emfilermin, CDF, Differentiation-stimulating factor, MLPLI, D-FACTOR, HILDA, Melanoma-derived LPL inhibitor

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:4.70 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:5.75 小脳:5.78 脳幹:5.79 脳梁:5.76 松果体:- 末梢神経:5.74 脊柱:6.12 網膜:- 目:- 動脈:6.52 静脈:7.21 リンパ節:6.05 末梢血:- 脾臓:5.79 胸腺:5.47 骨髄:6.15 脂肪:6.26 骨:- 皮膚:6.04
CAGE 大脳:0.52 小脳:- 脳幹:0.87 脳梁:0.59 松果体:0.62 末梢神経:- 脊柱:1.34 網膜:- 目:- 動脈:2.26 静脈:0.70 リンパ節:1.12 末梢血:- 脾臓:0.39 胸腺:0.23 骨髄:- 脂肪:1.01 骨:- 皮膚:-
RNA-seq 大脳:0.18 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.61 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.08 骨:- 皮膚:-
EST 子宮:- 胎盤:7.30 前立腺:11.30 卵巣:- 精巣:17.30 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:10.60        肺:24.40    膀胱:- 腎臓:62.40 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:6.08 胎盤:5.56 前立腺:5.96 卵巣:5.99 精巣:5.44 心臓:6.01 骨格筋:6.23 食道:5.90 胃:6.13 腸:6.25 結腸:6.51 肝臓:6.04 肺:7.09 膀胱:- 腎臓:5.82 下垂体:6.07 甲状腺:5.90 副腎:5.96 膵臓:6.17 乳腺:6.33 唾液腺:5.60
CAGE 子宮:0.99 胎盤:0.43 前立腺:1.11 卵巣:1.64 精巣:0.41 心臓:1.91 骨格筋:0.33 食道:0.57 胃:- 腸:0.80 結腸:1.06     肝臓:0.26    肺:1.93 膀胱:2.20 腎臓:0.74 下垂体:0.40 甲状腺:0.28 副腎:- 膵臓:0 乳腺:0.90 唾液腺:0.62
RNA-seq 子宮:- 胎盤:- 前立腺:0.66 卵巣:1.22 精巣:0.35 心臓:0.32 骨格筋:0 食道:- 胃:- 腸:- 結腸:0.56     肝臓:0.11        肺:2.50    膀胱:- 腎臓:0.55 下垂体:- 甲状腺:0.66 副腎:0.76 膵臓:- 乳腺:0.76 唾液腺:-

IDs

Refseq ID NM_002309
Gene ID 3976
Unigene ID Hs.22500
Probe set ID 205266_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000128342
GTEx ID ENSG00000128342

オーソログ対応遺伝子

マウス[6]  NM_001039537, NM_008501
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

遺伝子オントロジー  (GO ID)

Biological Process

GO:0001974  blood vessel remodeling
GO:0046697  decidualization
GO:0007566  embryo implantation
GO:0006955  immune response
GO:0048861  leukemia inhibitory factor signaling pathway
GO:0048286  lung alveolus development
GO:0060463  lung lobe morphogenesis
GO:0060426  lung vasculature development
GO:0007275  multicellular organismal development
GO:0048644  muscle organ morphogenesis
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0046888  negative regulation of hormone secretion
GO:0045835  negative regulation of meiosis
GO:0048666  neuron development
GO:0048711  positive regulation of astrocyte differentiation
GO:0008284  positive regulation of cell proliferation
GO:0045651  positive regulation of macrophage differentiation
GO:0043410  positive regulation of MAPKKK cascade
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0033141  positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042511  positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0060708  spongiotrophoblast differentiation
GO:0019827  stem cell maintenance
GO:0060707  trophoblast giant cell differentiation
GO:0042503  tyrosine phosphorylation of Stat3 protein

Cellular Component

GO:0005737  cytoplasm
GO:0005615  extracellular space

Molecular Function

GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0005146  leukemia inhibitory factor receptor binding
GO:0005102  receptor binding