SMAD family member 3

同義遺伝子名

hSMAD3, MADH3, Smad-3, JV15-2, hMAD-3, Mothers against decapentaplegic homolog 3, HSPC193, Mothers against DPP homolog 3, MGC60396, SMAD, mothers against DPP homolog 3 (Drosophila), HsT17436, Smad 3, DKFZp686J10186, SMAD3, Mad3, SMAD 3, DKFZP586N0721, SMAD-3

正常組織・臓器 40分類
細胞株・初代培養細胞・成体組織・胎児組織 (FANTOM5 CAGE)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

nodata

GeneChip

大脳:6.66

小脳:6.14

脳幹:6.10

脳梁:6.31

松果体:-

末梢神経:6.55

脊柱:6.60

網膜:-

目:-

動脈:7.45

静脈:7.20

リンパ節:7.53

末梢血:-

脾臓:7.67

胸腺:6.74

骨髄:6.41

脂肪:7.24

骨:-

皮膚:7.21

CAGE

大脳:2.75

小脳:-

脳幹:2.47

脳梁:2.78

松果体:3.48

末梢神経:-

脊柱:2.74

網膜:-

目:-

動脈:4.04

静脈:3.71

リンパ節:3.69

末梢血:-

脾臓:3.12

胸腺:2.91

骨髄:-

脂肪:3.91

骨:-

皮膚:-

RNA-seq

大脳:2.14

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:3.29

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:0.00

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

nodata

GeneChip

子宮:7.38

胎盤:6.47

前立腺:7.11

卵巣:7.47

精巣:5.68

心臓:6.94

骨格筋:8

食道:7.38

胃:7.01

腸:7.03

結腸:6.89

肝臓:6.74

肺:7.24

膀胱:-

腎臓:7.23

下垂体:6.96

甲状腺:7.91

副腎:6.42

膵臓:6.65

乳腺:7.39

唾液腺:6.87

CAGE

子宮:3.76

胎盤:2.80

前立腺:3.76

卵巣:3.61

精巣:2.41

心臓:3.77

骨格筋:4.21

食道:4.00

胃:-

腸:3.52

結腸:3.58

肝臓:2.66

肺:3.51

膀胱:4.11

腎臓:2.97

下垂体:2.72

甲状腺:3.68

副腎:-

膵臓:2.98

乳腺:3.76

唾液腺:3.29

RNA-seq

子宮:-

胎盤:-

前立腺:3.28

卵巣:2.65

精巣:1.78

心臓:1.22

骨格筋:0.21

食道:-

胃:-

腸:-

結腸:1.81

肝臓:1.03

肺:3.13

膀胱:-

腎臓:2.00

下垂体:-

甲状腺:0.00

副腎:2.34

膵臓:-

乳腺:1.58

唾液腺:-

IDs

Refseq ID	NM_001145104
Gene ID	4088
Unigene ID	-
Probe set ID	218284_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000166949
GTEx ID	ENSG00000166949

オーソログ対応遺伝子

マウス[2]	NM_016769
ラット [0]

染色体

15q22.33 [67,358,183 - 67,487,533]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR003619	MAD homology 1, Dwarfin-type
IPR013019	MAD homology, MH1
IPR001132	SMAD domain, Dwarfin-type
IPR017855	SMAD domain-like
IPR008984	SMAD/FHA domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0032924	activin receptor signaling pathway
GO:0007050	cell cycle arrest
GO:0045216	cell-cell junction organization
GO:0048589	developmental growth
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048617	embryonic foregut morphogenesis
GO:0009880	embryonic pattern specification
GO:0007492	endoderm development
GO:0019049	evasion of host defenses by virus
GO:0010467	gene expression
GO:0001947	heart looping
GO:0006955	immune response
GO:0002520	immune system development
GO:0001701	in utero embryonic development
GO:0070306	lens fiber cell differentiation
GO:0001889	liver development
GO:0001707	mesoderm formation
GO:0043066	negative regulation of apoptosis
GO:0030308	negative regulation of cell growth
GO:0050728	negative regulation of inflammatory response
GO:0045930	negative regulation of mitotic cell cycle
GO:0045668	negative regulation of osteoblast differentiation
GO:0033689	negative regulation of osteoblast proliferation
GO:0001933	negative regulation of protein amino acid phosphorylation
GO:0042177	negative regulation of protein catabolic process
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0002076	osteoblast development
GO:0048340	paraxial mesoderm morphogenesis
GO:0060039	pericardium development
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0030501	positive regulation of bone mineralization
GO:0030335	positive regulation of cell migration
GO:0032332	positive regulation of chondrocyte differentiation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0051894	positive regulation of focal adhesion formation
GO:0032731	positive regulation of interleukin-1 beta production
GO:0050927	positive regulation of positive chemotaxis
GO:0051496	positive regulation of stress fiber formation
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0032916	positive regulation of transforming growth factor-beta3 production
GO:0031053	primary microRNA processing
GO:0050821	protein stabilization
GO:0051098	regulation of binding
GO:0050678	regulation of epithelial cell proliferation
GO:0050776	regulation of immune response
GO:0016202	regulation of striated muscle tissue development
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0032909	regulation of transforming growth factor-beta2 production
GO:0001836	release of cytochrome c from mitochondria
GO:0001666	response to hypoxia
GO:0007183	SMAD protein complex assembly
GO:0001756	somitogenesis
GO:0042110	T cell activation
GO:0030878	thyroid gland development
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006351	transcription, DNA-dependent
GO:0060290	transdifferentiation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0006810	transport
GO:0001657	ureteric bud development
GO:0042060	wound healing

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005637	nuclear inner membrane
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0043235	receptor complex
GO:0071141	SMAD protein complex
GO:0005667	transcription factor complex

Molecular Function

GO:0008013	beta-catenin binding
GO:0031490	chromatin DNA binding
GO:0070410	co-SMAD binding
GO:0005518	collagen binding
GO:0044212	DNA regulatory region binding
GO:0003690	double-stranded DNA binding
GO:0019902	phosphatase binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0019901	protein kinase binding
GO:0070412	R-SMAD binding
GO:0043565	sequence-specific DNA binding
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding
GO:0005160	transforming growth factor beta receptor binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0043130	ubiquitin binding
GO:0031625	ubiquitin protein ligase binding
GO:0008270	zinc ion binding

SMAD family member 3

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function