SMAD family member 3

詳細情報を見る

同義遺伝子名

hSMAD3, MADH3, Smad-3, JV15-2, hMAD-3, Mothers against decapentaplegic homolog 3, HSPC193, Mothers against DPP homolog 3, MGC60396, SMAD, mothers against DPP homolog 3 (Drosophila), HsT17436, Smad 3, DKFZp686J10186, SMAD3, Mad3, SMAD 3, DKFZP586N0721, SMAD-3

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST nodata
GeneChip 大脳:6.66 小脳:6.14 脳幹:6.10 脳梁:6.31 松果体:- 末梢神経:6.55 脊柱:6.60 網膜:- 目:- 動脈:7.45 静脈:7.20 リンパ節:7.53 末梢血:- 脾臓:7.67 胸腺:6.74 骨髄:6.41 脂肪:7.24 骨:- 皮膚:7.21
CAGE 大脳:2.75 小脳:- 脳幹:2.47 脳梁:2.78 松果体:3.48 末梢神経:- 脊柱:2.74 網膜:- 目:- 動脈:4.04 静脈:3.71 リンパ節:3.69 末梢血:- 脾臓:3.12 胸腺:2.91 骨髄:- 脂肪:3.91 骨:- 皮膚:-
RNA-seq 大脳:2.14 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.29 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.00 骨:- 皮膚:-
EST nodata
GeneChip 子宮:7.38 胎盤:6.47 前立腺:7.11 卵巣:7.47 精巣:5.68 心臓:6.94 骨格筋:8 食道:7.38 胃:7.01 腸:7.03 結腸:6.89 肝臓:6.74 肺:7.24 膀胱:- 腎臓:7.23 下垂体:6.96 甲状腺:7.91 副腎:6.42 膵臓:6.65 乳腺:7.39 唾液腺:6.87
CAGE 子宮:3.76 胎盤:2.80 前立腺:3.76 卵巣:3.61 精巣:2.41 心臓:3.77 骨格筋:4.21 食道:4.00 胃:- 腸:3.52 結腸:3.58     肝臓:2.66    肺:3.51 膀胱:4.11 腎臓:2.97 下垂体:2.72 甲状腺:3.68 副腎:- 膵臓:2.98 乳腺:3.76 唾液腺:3.29
RNA-seq 子宮:- 胎盤:- 前立腺:3.28 卵巣:2.65 精巣:1.78 心臓:1.22 骨格筋:0.21 食道:- 胃:- 腸:- 結腸:1.81     肝臓:1.03        肺:3.13    膀胱:- 腎臓:2.00 下垂体:- 甲状腺:0.00 副腎:2.34 膵臓:- 乳腺:1.58 唾液腺:-

IDs

Refseq ID NM_001145104
Gene ID 4088
Unigene ID -
Probe set ID 218284_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000166949
GTEx ID ENSG00000166949

オーソログ対応遺伝子

マウス[2]  NM_016769
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0032924  activin receptor signaling pathway
GO:0007050  cell cycle arrest
GO:0045216  cell-cell junction organization
GO:0048589  developmental growth
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0048617  embryonic foregut morphogenesis
GO:0009880  embryonic pattern specification
GO:0007492  endoderm development
GO:0019049  evasion of host defenses by virus
GO:0010467  gene expression
GO:0001947  heart looping
GO:0006955  immune response
GO:0002520  immune system development
GO:0001701  in utero embryonic development
GO:0070306  lens fiber cell differentiation
GO:0001889  liver development
GO:0001707  mesoderm formation
GO:0043066  negative regulation of apoptosis
GO:0030308  negative regulation of cell growth
GO:0050728  negative regulation of inflammatory response
GO:0045930  negative regulation of mitotic cell cycle
GO:0045668  negative regulation of osteoblast differentiation
GO:0033689  negative regulation of osteoblast proliferation
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0042177  negative regulation of protein catabolic process
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0002076  osteoblast development
GO:0048340  paraxial mesoderm morphogenesis
GO:0060039  pericardium development
GO:0010694  positive regulation of alkaline phosphatase activity
GO:0030501  positive regulation of bone mineralization
GO:0030335  positive regulation of cell migration
GO:0032332  positive regulation of chondrocyte differentiation
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0051894  positive regulation of focal adhesion formation
GO:0032731  positive regulation of interleukin-1 beta production
GO:0050927  positive regulation of positive chemotaxis
GO:0051496  positive regulation of stress fiber formation
GO:0042993  positive regulation of transcription factor import into nucleus
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0032916  positive regulation of transforming growth factor-beta3 production
GO:0031053  primary microRNA processing
GO:0050821  protein stabilization
GO:0051098  regulation of binding
GO:0050678  regulation of epithelial cell proliferation
GO:0050776  regulation of immune response
GO:0016202  regulation of striated muscle tissue development
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0032909  regulation of transforming growth factor-beta2 production
GO:0001836  release of cytochrome c from mitochondria
GO:0001666  response to hypoxia
GO:0007183  SMAD protein complex assembly
GO:0001756  somitogenesis
GO:0042110  T cell activation
GO:0030878  thyroid gland development
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0006351  transcription, DNA-dependent
GO:0060290  transdifferentiation
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0006810  transport
GO:0001657  ureteric bud development
GO:0042060  wound healing

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005637  nuclear inner membrane
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043235  receptor complex
GO:0071141  SMAD protein complex
GO:0005667  transcription factor complex

Molecular Function

GO:0008013  beta-catenin binding
GO:0031490  chromatin DNA binding
GO:0070410  co-SMAD binding
GO:0005518  collagen binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0019902  phosphatase binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0070412  R-SMAD binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding
GO:0005160  transforming growth factor beta receptor binding
GO:0030618  transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0043130  ubiquitin binding
GO:0031625  ubiquitin protein ligase binding
GO:0008270  zinc ion binding