mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

詳細情報を見る

同義遺伝子名

HNPCC, DNA mismatch repair protein Msh2, MutS protein homolog 2, COCA1, MSH2, FCC1, HNPCC1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:2.40 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:20.20 末梢血:- 脾臓:- 胸腺:12.90 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:5.58 小脳:5.56 脳幹:5.77 脳梁:5.26 松果体:- 末梢神経:5.26 脊柱:5.40 網膜:- 目:- 動脈:4.44 静脈:4.50 リンパ節:5.08 末梢血:- 脾臓:4.90 胸腺:7.02 骨髄:5.71 脂肪:5.04 骨:- 皮膚:4.94
CAGE 大脳:3.06 小脳:- 脳幹:2.91 脳梁:2.34 松果体:4.05 末梢神経:- 脊柱:2.63 網膜:- 目:- 動脈:1.72 静脈:2.33 リンパ節:2.60 末梢血:- 脾臓:2.34 胸腺:3.63 骨髄:- 脂肪:2.10 骨:- 皮膚:-
RNA-seq 大脳:3.22 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.21 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.44 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:37.30 精巣:- 心臓:12.80 骨格筋:- 食道:- 胃:- 腸:- 結腸:17     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:18.60 唾液腺:-
GeneChip 子宮:5.41 胎盤:4.72 前立腺:5.35 卵巣:5.81 精巣:6.10 心臓:5 骨格筋:4.71 食道:5.27 胃:4.53 腸:4.87 結腸:4.52 肝臓:4.33 肺:4.46 膀胱:- 腎臓:4.65 下垂体:5.13 甲状腺:5.31 副腎:4.67 膵臓:5.09 乳腺:5.37 唾液腺:4.82
CAGE 子宮:2.30 胎盤:2.21 前立腺:2.10 卵巣:1.98 精巣:2.67 心臓:2.10 骨格筋:1.39 食道:1.92 胃:- 腸:1.98 結腸:2.20     肝臓:0.71    肺:1.97 膀胱:1.81 腎臓:1.80 下垂体:2.60 甲状腺:2.44 副腎:- 膵臓:2.08 乳腺:1.36 唾液腺:1.49
RNA-seq 子宮:- 胎盤:- 前立腺:3.10 卵巣:2.90 精巣:3.86 心臓:2.24 骨格筋:1.64 食道:- 胃:- 腸:- 結腸:2.69     肝臓:1.20        肺:1.78    膀胱:- 腎臓:3.19 下垂体:- 甲状腺:3.18 副腎:2.68 膵臓:- 乳腺:2.70 唾液腺:-

IDs

Refseq ID NM_000251
Gene ID 4436
Unigene ID Hs.597656
Probe set ID 209421_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000095002
GTEx ID ENSG00000095002

オーソログ対応遺伝子

マウス[1]  NM_008628
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0030183  B cell differentiation
GO:0019724  B cell mediated immunity
GO:0007050  cell cycle arrest
GO:0008340  determination of adult lifespan
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006281  DNA repair
GO:0006302  double-strand break repair
GO:0007281  germ cell development
GO:0001701  in utero embryonic development
GO:0031573  intra-S DNA damage checkpoint
GO:0045190  isotype switching
GO:0043570  maintenance of DNA repeat elements
GO:0008584  male gonad development
GO:0006311  meiotic gene conversion
GO:0000710  meiotic mismatch repair
GO:0006298  mismatch repair
GO:0045910  negative regulation of DNA recombination
GO:0043524  negative regulation of neuron apoptosis
GO:0045128  negative regulation of reciprocal meiotic recombination
GO:0006119  oxidative phosphorylation
GO:0051096  positive regulation of helicase activity
GO:0006301  postreplication repair
GO:0010224  response to UV-B
GO:0010165  response to X-ray
GO:0016446  somatic hypermutation of immunoglobulin genes
GO:0016447  somatic recombination of immunoglobulin gene segments

Cellular Component

GO:0032301  MutSalpha complex
GO:0032302  MutSbeta complex
GO:0000228  nuclear chromosome

Molecular Function

GO:0043531  ADP binding
GO:0005524  ATP binding
GO:0016887  ATPase activity
GO:0019237  centromeric DNA binding
GO:0032139  dinucleotide insertion or deletion binding
GO:0032181  dinucleotide repeat insertion binding
GO:0003677  DNA binding
GO:0008094  DNA-dependent ATPase activity
GO:0000406  double-strand/single-strand DNA junction binding
GO:0003690  double-stranded DNA binding
GO:0019899  enzyme binding
GO:0000400  four-way junction DNA binding
GO:0032137  guanine/thymine mispair binding
GO:0000404  loop DNA binding
GO:0000287  magnesium ion binding
GO:0030983  mismatched DNA binding
GO:0032405  MutLalpha complex binding
GO:0032357  oxidized purine DNA binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0032142  single guanine insertion binding
GO:0032143  single thymine insertion binding
GO:0003697  single-stranded DNA binding
GO:0000403  Y-form DNA binding