nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

詳細情報を見る

同義遺伝子名

I-kappa-B-alpha, IKB-alpha, NFKBI, IKBA, NFKBIA, NF-kappa-B inhibitor alpha, MAD3, MAD-3, IkappaBalpha

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:27.30 小脳:37.80 脳幹:- 脳梁:58.30 松果体:- 末梢神経:92 脊柱:- 網膜:- 目:123.40 動脈:60 静脈:- リンパ節:839.20 末梢血:255.10 脾臓:170.20 胸腺:25.80 骨髄:59 脂肪:201.70 骨:64 皮膚:76.80
GeneChip 大脳:8.29 小脳:8.40 脳幹:8.01 脳梁:8.85 松果体:- 末梢神経:9.69 脊柱:9.67 網膜:- 目:- 動脈:10.41 静脈:11.60 リンパ節:10.38 末梢血:- 脾臓:10.75 胸腺:9.57 骨髄:9.78 脂肪:10.26 骨:- 皮膚:10.33
CAGE 大脳:4.09 小脳:- 脳幹:4.20 脳梁:3.92 松果体:3.94 末梢神経:- 脊柱:4.91 網膜:- 目:- 動脈:5.32 静脈:5.31 リンパ節:5.13 末梢血:- 脾臓:5.24 胸腺:4.87 骨髄:- 脂肪:5.45 骨:- 皮膚:-
RNA-seq 大脳:4.78 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:6.60 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:5.18 骨:- 皮膚:-
EST 子宮:54.70 胎盤:331.50 前立腺:169 卵巣:- 精巣:21.60 心臓:140.50 骨格筋:160.70 食道:- 胃:191.20 腸:64.80 結腸:59.40     肝臓:63.30        肺:224.80    膀胱:125.60 腎臓:31.20 下垂体:347.90 甲状腺:- 副腎:152.40 膵臓:151.10 乳腺:139.40 唾液腺:-
GeneChip 子宮:9.81 胎盤:9.61 前立腺:9.66 卵巣:10.34 精巣:8.31 心臓:9.87 骨格筋:8.59 食道:10.27 胃:10.13 腸:9.49 結腸:10.31 肝臓:10.08 肺:12.18 膀胱:- 腎臓:9.74 下垂体:9.06 甲状腺:10.12 副腎:11.15 膵臓:8.46 乳腺:10.52 唾液腺:9.63
CAGE 子宮:4.77 胎盤:4.65 前立腺:4.93 卵巣:5.14 精巣:4.31 心臓:5.03 骨格筋:4.97 食道:5.43 胃:- 腸:5.23 結腸:4.96     肝臓:4.72    肺:5.83 膀胱:5.25 腎臓:4.87 下垂体:4.65 甲状腺:4.76 副腎:- 膵臓:4.36 乳腺:5.69 唾液腺:4.32
RNA-seq 子宮:- 胎盤:- 前立腺:6.54 卵巣:5.94 精巣:6.01 心臓:5.22 骨格筋:5.93 食道:- 胃:- 腸:- 結腸:5.53     肝臓:5.48        肺:8.22    膀胱:- 腎臓:5.98 下垂体:- 甲状腺:5.70 副腎:6.96 膵臓:- 乳腺:5.05 唾液腺:-

IDs

Refseq ID NM_020529
Gene ID 4792
Unigene ID Hs.81328
Probe set ID 201502_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100906
GTEx ID ENSG00000100906

オーソログ対応遺伝子

マウス[3]  NM_010907
ラット[2]  NM_001105720

染色体

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1427874
1493333
1829648
3140380
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7628694
7679069
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0070417  cellular response to cold
GO:0007253  cytoplasmic sequestering of NF-kappaB
GO:0042994  cytoplasmic sequestering of transcription factor
GO:0045087  innate immune response
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0043392  negative regulation of DNA binding
GO:0010888  negative regulation of lipid storage
GO:0010745  negative regulation of macrophage derived foam cell differentiation
GO:0045638  negative regulation of myeloid cell differentiation
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0045746  negative regulation of Notch signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0070427  nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431  nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0032270  positive regulation of cellular protein metabolic process
GO:0010875  positive regulation of cholesterol efflux
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032481  positive regulation of type I interferon production
GO:0000060  protein import into nucleus, translocation
GO:0042127  regulation of cell proliferation
GO:0042345  regulation of NF-kappaB import into nucleus
GO:0043330  response to exogenous dsRNA
GO:0032495  response to muramyl dipeptide
GO:0050852  T cell receptor signaling pathway
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0019048  virus-host interaction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0033256  I-kappaB/NF-kappaB complex
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0019899  enzyme binding
GO:0031072  heat shock protein binding
GO:0042802  identical protein binding
GO:0051059  NF-kappaB binding
GO:0008139  nuclear localization sequence binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0008134  transcription factor binding
GO:0031625  ubiquitin protein ligase binding