furin (paired basic amino acid cleaving enzyme)

詳細情報を見る

同義遺伝子名

Paired basic amino acid residue cleaving enzyme, PACE, Dibasic-processing enzyme, FUR, FURIN, Furin precursor, SPC1, furin (paired basic amino acid cleaving enzyme), PCSK3

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:20.10 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:61.30 脊柱:112.30 網膜:- 目:58.80 動脈:30 静脈:199.90 リンパ節:141.50 末梢血:36.40 脾臓:18.90 胸腺:12.90 骨髄:19.70 脂肪:201.70 骨:25.60 皮膚:43.20
GeneChip 大脳:7.38 小脳:7.80 脳幹:7.33 脳梁:7.36 松果体:- 末梢神経:7.08 脊柱:7.05 網膜:- 目:- 動脈:7.34 静脈:7.51 リンパ節:7.34 末梢血:- 脾臓:7.41 胸腺:6.84 骨髄:7.80 脂肪:7.64 骨:- 皮膚:7.67
CAGE 大脳:0.31 小脳:- 脳幹:0.16 脳梁:0 松果体:0 末梢神経:- 脊柱:0.23 網膜:- 目:- 動脈:0.79 静脈:1.61 リンパ節:0.70 末梢血:- 脾臓:1.79 胸腺:1.18 骨髄:- 脂肪:2.07 骨:- 皮膚:-
RNA-seq 大脳:2.95 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:4.35 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:5.31 骨:- 皮膚:-
EST 子宮:18.20 胎盤:153 前立腺:33.80 卵巣:- 精巣:13 心臓:25.50 骨格筋:- 食道:- 胃:- 腸:32.40 結腸:17     肝臓:21.10        肺:48.90    膀胱:- 腎臓:52 下垂体:- 甲状腺:- 副腎:50.80 膵臓:88.90 乳腺:9.30 唾液腺:-
GeneChip 子宮:7.28 胎盤:9.07 前立腺:7.47 卵巣:7.28 精巣:6.92 心臓:7.60 骨格筋:7.61 食道:7.54 胃:7.32 腸:7.57 結腸:7.65 肝臓:8.66 肺:7.88 膀胱:- 腎臓:7.62 下垂体:7.49 甲状腺:7.80 副腎:7.37 膵臓:8.01 乳腺:7.29 唾液腺:9.65
CAGE 子宮:0.63 胎盤:5.32 前立腺:1.28 卵巣:1.11 精巣:1.10 心臓:1.02 骨格筋:1.56 食道:1.20 胃:- 腸:1.55 結腸:1.26     肝臓:4.91    肺:2.14 膀胱:0.73 腎臓:0.78 下垂体:0.50 甲状腺:1.30 副腎:- 膵臓:0.94 乳腺:0.55 唾液腺:5.96
RNA-seq 子宮:- 胎盤:- 前立腺:3.36 卵巣:3.48 精巣:3.38 心臓:3.40 骨格筋:4.15 食道:- 胃:- 腸:- 結腸:3.83     肝臓:6.61        肺:4.97    膀胱:- 腎臓:3.89 下垂体:- 甲状腺:5.61 副腎:4.31 膵臓:- 乳腺:4.54 唾液腺:-

IDs

Refseq ID NM_002569
Gene ID 5045
Unigene ID Hs.513153
Probe set ID 201945_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000140564
GTEx ID ENSG00000140564

オーソログ対応遺伝子

マウス[2]  NM_001081454, NM_011046
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1360148
1571548
1629222
1713771
1741956
2112085
2251280
2408021
2674906
3023061
7508380
7639757
7690548
7721880
7737999
7774724
7781597
7782070
8020465
8163529
8174106
8189547
8262946
8546712
8615794
8670066
8846780
8940009
8995623
9094426
9166946
9242664
9412467
9442015
9521771
9599222
9642263
9653148
9695949
9827567
9927419
10037747
10050053
10225274
10373500
10409610
10452538
10526337
10567353
10593987
10887202
10888676
10900462
11071887
11237874
11294867
11323410
11331585
11380615
11416205
11422372
11571266
11723118
11804956
11861638
11861826
11921231
12006600
12058031
12058067
12071862
12220680
12354117
12411321
12460941
12477932
12482870
12547702
12584323
12586364
12644459
12670890
12736257
12787574
14596804
14644155
14739277
14741044
14744861
15078902
15082773
15135058
15240540
15247425
15371436
15489334
15564468
15584904
15606899
15611046
15637056
15659365
15899807
15911696
16407210
16537537
16600625
16627761
16648485
16912035
16942750
17010968
17283058
17301129
17360815
17477394
17525470
17641413
17905608
17905609
17909005
17938254
17948127
18037384
18064302
18174282
18245819
18323532
18343183
18353966
18467449
18544638
18546152
18665212
18826955
19056739
19152512
19193799
19199708
19322201
19477160
19492430
19541935
19913121
19946888
19998449
20055586
20062797
20101215
20605791
20608975
20628086
20634490
20635860
20707915
20811902
20945401
21147780
21296375
21406565
21503879
21550985
21805236
21805237
21880759
21889147
21890473
21909115
21988832
22038627
22247010
22479394
22505724
22577343
22679642
22808247
22995191
23000965
23065687
23135270
23302673
23390091
23558288
23568742
23598405
23653353
23661674
23686857
23744066
23775089
23835774
23840860
23861967
23936445
24257604

遺伝子オントロジー  (GO ID)

Biological Process

GO:0008283  cell proliferation
GO:0044267  cellular protein metabolic process
GO:0030574  collagen catabolic process
GO:0022617  extracellular matrix disassembly
GO:0030198  extracellular matrix organization
GO:0032804  negative regulation of low-density lipoprotein receptor catabolic process
GO:0032904  negative regulation of nerve growth factor production
GO:0032911  negative regulation of transforming growth factor-beta1 production
GO:0032455  nerve growth factor processing
GO:0032902  nerve growth factor production
GO:0048011  nerve growth factor receptor signaling pathway
GO:0007219  Notch signaling pathway
GO:0043043  peptide biosynthetic process
GO:0016486  peptide hormone processing
GO:0017187  peptidyl-glutamic acid carboxylation
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0043687  post-translational protein modification
GO:0016485  protein processing
GO:0006508  proteolysis
GO:0052548  regulation of endopeptidase activity
GO:0042176  regulation of protein catabolic process
GO:0009966  regulation of signal transduction
GO:0032940  secretion by cell
GO:0006465  signal peptide processing
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0019067  viral assembly, maturation, egress, and release
GO:0019082  viral protein processing
GO:0016032  viral reproduction
GO:0019068  virion assembly

Cellular Component

GO:0009986  cell surface
GO:0005615  extracellular space
GO:0005796  Golgi lumen
GO:0000139  Golgi membrane
GO:0016021  integral to membrane
GO:0045121  membrane raft
GO:0005886  plasma membrane
GO:0005802  trans-Golgi network
GO:0030140  trans-Golgi network transport vesicle

Molecular Function

GO:0004175  endopeptidase activity
GO:0046872  metal ion binding
GO:0048406  nerve growth factor binding
GO:0008233  peptidase activity
GO:0042277  peptide binding
GO:0002020  protease binding
GO:0004252  serine-type endopeptidase activity
GO:0004867  serine-type endopeptidase inhibitor activity