protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

詳細情報を見る

同義遺伝子名

PP2CA, Replication protein C, PP2A-alpha, PP2Ac, RP-C, PPP2CA

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:14.20 小脳:12.60 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:118.60 目:23.50 動脈:- 静脈:- リンパ節:10.10 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:19.20
GeneChip 大脳:8.49 小脳:8.56 脳幹:8.76 脳梁:7.91 松果体:- 末梢神経:8.43 脊柱:8.10 網膜:- 目:- 動脈:7.59 静脈:7.89 リンパ節:7.85 末梢血:- 脾臓:7.83 胸腺:8.88 骨髄:7.78 脂肪:7.79 骨:- 皮膚:8.32
CAGE 大脳:0.07 小脳:- 脳幹:0.03 脳梁:0 松果体:0 末梢神経:- 脊柱:0 網膜:- 目:- 動脈:0 静脈:0 リンパ節:0.09 末梢血:- 脾臓:0.09 胸腺:0 骨髄:- 脂肪:0 骨:- 皮膚:-
RNA-seq 大脳:6.45 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:5.46 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:5.10 骨:- 皮膚:-
EST 子宮:36.50 胎盤:7.30 前立腺:56.30 卵巣:- 精巣:47.60 心臓:12.80 骨格筋:- 食道:- 胃:- 腸:- 結腸:25.40     肝臓:52.80        肺:4.90    膀胱:- 腎臓:31.20 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:9.30 唾液腺:-
GeneChip 子宮:8.06 胎盤:8.53 前立腺:8.37 卵巣:7.90 精巣:8.07 心臓:8.07 骨格筋:8.56 食道:8.45 胃:7.63 腸:7.90 結腸:7.51 肝臓:7.31 肺:8.03 膀胱:- 腎臓:7.97 下垂体:7.53 甲状腺:7.95 副腎:8.19 膵臓:7.37 乳腺:7.88 唾液腺:7.38
CAGE 子宮:0.06 胎盤:0.48 前立腺:0.08 卵巣:0 精巣:0.10 心臓:0.03 骨格筋:0 食道:0.09 胃:- 腸:0.38 結腸:0.46     肝臓:0.36    肺:0.39 膀胱:0 腎臓:0.27 下垂体:0.42 甲状腺:0.17 副腎:- 膵臓:0 乳腺:0.55 唾液腺:0
RNA-seq 子宮:- 胎盤:- 前立腺:5.61 卵巣:5.51 精巣:5.76 心臓:5.56 骨格筋:5.03 食道:- 胃:- 腸:- 結腸:5.46     肝臓:5.03        肺:5.94    膀胱:- 腎臓:5.78 下垂体:- 甲状腺:5.84 副腎:5.35 膵臓:- 乳腺:5.08 唾液腺:-

IDs

Refseq ID NM_002715
Gene ID 5515
Unigene ID Hs.105818
Probe set ID 208652_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000113575
GTEx ID ENSG00000113575

オーソログ対応遺伝子

マウス[2]  NM_019411
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1328247
1330687
1846293
1848320
1848668
2555176
2557326
2837763
2849764
4092695
7592815
8206937
8262976
8383590
8386634
8392375
8524402
8617797
8617805
8703017
9003791
9009195
9013886
9353299
9400615
9647778
9795170
9847399
9852076
9920888
9989501
10191253
10200280
10357815
10441131
10629059
10644691
10675325
10681496
10698523
10769027
10934208
11007961
11113010
11114196
11259605
11278485
11313937
11360189
11371618
11438723
11440634
11531413
11591705
11842093
11929874
11929880
11956189
11959144
11983168
12036313
12036952
12054646
12058047
12062430
12186863
12370081
12435421
12477932
12514180
12556559
12624094
12637511
12842894
12859198
12912990
12915404
14633983
14645548
14702039
14724252
15147202
15231747
15247211
15252037
15380617
15489334
15671020
15761153
15761952
16041367
16085932
16109716
16126728
16169070
16189514
16191191
16258073
16306228
16341674
16456541
16541025
16580887
16596250
16764867
17055435
17110338
17148452
17163575
17174897
17245430
17255109
17266553
17297438
17374643
17485487
17540176
17632056
17693927
17803990
17852432
17855368
17941990
17974561
18160256
18191226
18299321
18339811
18430997
18477699
18583989
18586681
18715871
18768864
18782753
18852266
18928587
18949047
18971272
18977201
19060904
19126401
19131971
19155497
19156129
19356149
19360341
19553685
19738201
19818709
20065038
20092282
20100830
20106966
20133759
20133760
20360068
20363734
20448038
20544796
20558158
20562864
20615878
20639865
20663872
20677014
20711181
20811636
21072166
21081666
21139048
21145461
21151953
21172653
21346232
21351466
21355954
21393425
21454489
21590681
21708940
21791414
21835928
21890473
21906983
21959857
21963094
21983900
21987572
21988832
21996587
22031698
22053931
22065577
22135143
22167190
22192750
22299668
22314363
22379092
22422068
22443683
22466704
22479341
22505724
22613722
22623428
22685328
22732552
22863883
22904676
22939629
22961627
22990118
23000965
23022380
23047923
23064762
23135275
23183242
23184344
23184937
23185379
23287597
23290789
23402259
23434594
23455922
23651848
23677989
23720779
23775084
23824909
23892082
23901063
24064353
24100030
24145130
24250222
24269630
24332808
24382322
24462681
24550388
24642616
24654937
24778252
24816145

遺伝子オントロジー  (GO ID)

Biological Process

GO:0006672  ceramide metabolic process
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0010467  gene expression
GO:0000188  inactivation of MAPK activity
GO:0006917  induction of apoptosis
GO:0007126  meiosis
GO:0007498  mesoderm development
GO:0000278  mitotic cell cycle
GO:0007084  mitotic nuclear envelope reassembly
GO:0016071  mRNA metabolic process
GO:0030308  negative regulation of cell growth
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0042518  negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0000184  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006470  protein amino acid dephosphorylation
GO:0070208  protein heterotrimerization
GO:0030155  regulation of cell adhesion
GO:0045595  regulation of cell differentiation
GO:0006275  regulation of DNA replication
GO:0040008  regulation of growth
GO:0031952  regulation of protein amino acid autophosphorylation
GO:0042176  regulation of protein catabolic process
GO:0010469  regulation of receptor activity
GO:0006355  regulation of transcription, DNA-dependent
GO:0030111  regulation of Wnt receptor signaling pathway
GO:0010033  response to organic substance
GO:0016070  RNA metabolic process
GO:0008380  RNA splicing
GO:0019932  second-messenger-mediated signaling

Cellular Component

GO:0000775  chromosome, centromeric region
GO:0005829  cytosol
GO:0016020  membrane
GO:0015630  microtubule cytoskeleton
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0000159  protein phosphatase type 2A complex
GO:0000922  spindle pole

Molecular Function

GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0046983  protein dimerization activity
GO:0004722  protein serine/threonine phosphatase activity